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Past, present and futute of cyclodextrin research
Open accessAbstract
The macrocyclic cyclodextrins (enzymic conversion products of starch) were discovered in 1891, and the structures were elucidated in the mid-1930s. Their industrial significance become obvious in the 1970s, and by now thousand of tons of the three cyclodextrins (alpha-, beta-, and gamma-CD) and of their chemical derivatives and inclusion complexes are produced industrially. The outer surface of these doughnut-shaped molecules is hydrophilic, but they possess an axial open cavity, which is of hydrophobic character and capable of including other apolar molecules (or their moiety) in case of geometric compatibility. This is the essence of molecular encapsulation by inclusion complex formation.
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Cited by
Review: A History of Cyclodextrins
Crini, G. (2014) · Chemical Reviews · doi:10.1021/cr500081p · Cited by 1,906
Cyclodextrins and their pharmaceutical applications
LOFTSSON, T., & DUCHENE, D. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.10.044 · Cited by 1,764
A review of stimuli-responsive polymers for smart textile applications
Hu, J., Meng, H., Li, G., & Ibekwe, S. I. (2012) · Smart Materials and Structures · doi:10.1088/0964-1726/21/5/053001 · Cited by 639
Cyclodextrin based novel drug delivery systems
Vyas, A., Saraf, S., & Saraf, S. (2008) · Journal of Inclusion Phenomena and Macrocyclic Chemistry · doi:10.1007/s10847-008-9456-y · Cited by 412
Nuchuchua, O., Saesoo, S., Sramala, I., Puttipipatkhachorn, S., Soottitantawat, A., & Ruktanonchai, U. (2009) · Food Research International · doi:10.1016/j.foodres.2009.06.006 · Cited by 74
Metadata
- Authors
- Szejtli, J.
- Venue
- Pure and Applied Chemistry
- Publisher
- Walter de Gruyter GmbH
- Published
- 2004-01-01
- Volume
- 76
- Issue
- 10
- Pages
- 1825-1845
- ISSN
- 0033-4545 (ISSN-L)
- 1365-3075
- OpenAlex
- W2079727806
- Cited by
- 606
- References
- 0
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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