Cited by 172Cholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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The role of acetylcholinesterase in the pathogenesis of Alzheimer's disease

Rees, T.M., Brimijoin, S.·2003·Drugs of today

DOI 10.1358/dot.2003.39.1.740206

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Abstract

Treatment of Alzheimer's disease has been dominated by the use of acetylcholinesterase (AChE) inhibitors. These drugs compensate for the death of cholinergic neurons and offer symptomatic relief by inhibiting acetylcholine (ACh) turnover and restoring synaptic levels of this neurotransmitter. Recently, however, AChE itself has been implicated in the pathogenesis of Alzheimer's disease. In particular, it appears that AChE may directly interact with amyloid-beta in a manner that increases the deposition of this peptide into insoluble plaques. This new role suggests that properly designed AChE inhibitors might be able to act as disease-modifying agents rather than as mere palliatives. Additionally, numerous studies have suggested that cholinergic modulation and other functional consequences of AChE inhibition may affect amyloid precursor protein processing and protect neurons against a variety of insults. It therefore seems likely that new AChE inhibitors, which capitalize on all these strengths would be excellent candidates for future Alzheimer's disease therapy.

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Authors: Rees, T. M., & Brimijoin, S.
Affiliations: Mayo Clinic (US)
ORCID: Brimijoin, S.
Venue: Drugs of today
Publisher: Portico
Published: 2003
Volume: 39
Issue: 1
Pages: 75
ISSN: 0025-7656 (ISSN-L)
1699-4019
DOI: 10.1358/dot.2003.39.1.740206
OpenAlex: W1966053837
Cited by: 171
References: 0
Citations by year: 2026: 16 · 2025: 21 · 2024: 23 · 2023: 25 · 2022: 25 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 3
FWCI: 2.79
Type: journal article
Language: en
Open access: closed
Locations: Drugs of today (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG 16574, P50AG016574)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: acetylcholinesterase, Alzheimer's disease pathogenesis, acetylcholinesterase inhibitors, amyloid-beta deposition, amyloid plaques, cholinergic neurons, APP processing, disease-modifying therapy, acetylcholine neurotransmission
MeSH terms: Acetylcholinesterase, Alzheimer Disease, Animals, Cholinesterase Inhibitors, Humans

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The role of acetylcholinesterase in the pathogenesis of Alzheimer's disease

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