Clinical pharmacokinetics of statins
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Simvastatin is a hypolipidemic agent administered as an inactive prodrug, simvastatin lactone (SVL), which is converted to the active form, simvastatin acid (SVA), via carboxylesterases and paraoxonases mainly expressed in the liver and plasma.
“Simvastatin is a hypolipidemic agent administered as an inactive prodrug, simvastatin lactone (SVL), which is converted to the active form, simvastatin acid (SVA), via carboxylesterases and paraoxonases mainly expressed in the liver and plasma. 18 , 19 , 20”
From Does the choice of applied physiologically‐based pharmacokinetics platform matter? A case study on simvastatin disposition and drug–drug interaction (2022) · cites this paper as [20]
Cited by
Sorted by citations
Statin use and reduced cancer-related mortality
Nielsen, S. F., Nordestgaard, B. G., & Bojesen, S. E. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1201735 · Cited by 1,030 · see citing works
Hargreaves, I. P., Duncan, A. J., Heales, S. J. R., & Land, J. M. (2005) · Drug Safety · doi:10.2165/00002018-200528080-00002 · Cited by 91 · see citing works
Kristiansen, O., Vethe, N. T., Peersen, K., Wang Fagerland, M., Sverre, E., Prunés Jensen, E., Lindberg, M., Gjertsen, E., Gullestad, L., Perk, J., et al. (2021) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvaa076 · Cited by 27 · see citing works
Prieto Garcia, L., Lundahl, A., Ahlström, C., Vildhede, A., Lennernäs, H., & Sjögren, E. (2022) · CPT: Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12837 · Cited by 21 · see citing works
- Authors
- Garcia, M. J., Reinoso, R. F., Sanchez Navarro, A., & Prous, J. R.
- ORCID
- Reinoso, R.F.
- Venue
- Methods and Findings in Experimental and Clinical Pharmacology
- Publisher
- Portico
- Published
- 2003
- Volume
- 25
- Issue
- 6
- Pages
- 455
- ISSN
- 0379-0355 (ISSN-L)
- OpenAlex
- W4297821733
- Cited by
- 121
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 15 · 2019: 7 · 2018: 8 · 2017: 3 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 4
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Methods and Findings in Experimental and Clinical Pharmacology (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- statins, clinical pharmacokinetics, drug absorption, drug distribution, drug metabolism, drug excretion, lipid-lowering drugs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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