Regional Responsiveness of the Tibia to Intermittent Administration of Parathyroid Hormone as Affected by Skeletal Unloading

Halloran, Bernard P.; Bikle, Daniel D.; Harris, Jonathan; Tanner, Sharon; Curren, Tracy; Morey-Holton, Emily

doi:10.1359/jbmr.1997.12.7.1068

Regional Responsiveness of the Tibia to Intermittent Administration of Parathyroid Hormone as Affected by Skeletal Unloading

To determine whether the acute inhibition of bone formation and deficit in bone mineral induced by skeletal unloading can be prevented, we studied the effects of intermittent parathyroid hormone (PTH) administration (8 μg/100 g/day) on growing rats submitted to 8 days of skeletal unloading. Loss …