Evidence From the Aged Orchidectomized Male Rat Model That 17β-Estradiol Is a More Effective Bone-Sparing and Anabolic Agent Than 5α-Dihydrotestosterone

Vandenput, L.; Boonen, S.; Van Herck, E.; Swinnen, J. V.; Bouillon, R.; Vanderschueren, D.

doi:10.1359/jbmr.2002.17.11.2080

Evidence From the Aged Orchidectomized Male Rat Model That 17β-Estradiol Is a More Effective Bone-Sparing and Anabolic Agent Than 5α-Dihydrotestosterone

This study was designed to evaluate the impact of estrogen versus androgen action on orchidectomy (ORX)-induced bone loss and associated changes in body composition. During an experimental period of 4 months, aged (12-month-old) ORX rats were treated with 17β-estradiol (E2; 0.75 μg/day) or differ…