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Ultrahigh-resolution full-field optical coherence tomography
Abstract
We have developed a white-light interference microscope for ultrahigh-resolution full-field optical coherence tomography of biological media. The experimental setup is based on a Linnik-type interferometer illuminated by a tungsten halogen lamp. En face tomographic images are calculated by a combination of interferometric images recorded by a high-speed CCD camera. Spatial resolution of 1.8 microm x 0.9 microm (transverse x axial) is achieved owing to the extremely short coherence length of the source, the compensation of dispersion mismatch in the interferometer arms, and the use of relatively high-numerical-aperture microscope objectives. A shot-noise-limited detection sensitivity of 90 dB is obtained in an acquisition time per image of 4 s. Subcellular-level images of plant, animal, and human tissues are presented.
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Citations
Cited by
State-of-the-art retinal optical coherence tomography
DREXLER, W., & FUJIMOTO, J. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2007.07.005 · Cited by 906
PODOLEANU, A. G. (2012) · Journal of Microscopy · doi:10.1111/j.1365-2818.2012.03619.x · Cited by 348
Present Application and Perspectives of Organoid Imaging Technology
Fei, K., Zhang, J., Yuan, J., & Xiao, P. (2022) · Bioengineering · doi:10.3390/bioengineering9030121 · Cited by 65
Metadata
- Authors
- Dubois, A., Grieve, K., Moneron, G., Lecaque, R., Vabre, L., & Boccara, C.
- Venue
- Applied Optics
- Publisher
- Optica Publishing Group
- Published
- 2004-05-10
- Volume
- 43
- Issue
- 14
- Pages
- 2874
- ISSN
- 0003-6935 (ISSN-L)
- 1539-4522
- OpenAlex
- W2014330639
- Cited by
- 394
- References
- 0
- FWCI
- 13.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Ultrahigh-resolution full-field optical coherence tomography. https://app.cochat.ai/papers/10.1364/ao.43.002874
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- Dubois, A., Grieve, K., Moneron, G., Lecaque, R., Vabre, L., & Boccara, C. (2004). Ultrahigh-resolution full-field optical coherence tomography. Applied Optics. https://doi.org/10.1364/ao.43.002874
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