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Plasmon-resonant gold nanorods as low backscattering albedo contrast agents for optical coherence tomography
Open accessAbstract
Plasmon-resonant gold nanorods are demonstrated as low backscattering albedo contrast agents for optical coherence tomography (OCT). We define the backscattering albedo, a', as the ratio of the backscattering to extinction coefficient. Contrast agents which modify a' within the host tissue phantoms are detected with greater sensitivity by the differential OCT measurement of both a' and extinction. Optimum sensitivity is achieved by maximizing the difference between contrast agents and tissue, |a'(ca) - a'(tiss)|. Low backscattering albedo gold nanorods (14x 44 nm; lambda(max) = 780 nm) within a high backscattering albedo tissue phantom with an uncertainty in concentration of 20% (randomized 2+/-0.4% intralipid) were readily detected at 82 ppm (by weight) in a regime where extinction alone could not discriminate nanorods. The estimated threshold of detection was 30 ppm.
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Cites
Chemistry and Properties of Nanocrystals of Different Shapes
Burda, C., Chen, X., Narayanan, R., & El-Sayed, M. A. (2005) · Chemical Reviews · doi:10.1021/cr030063a · Cited by 7,230
A review of the optical properties of biological tissues
Cheong, W. F., Prahl, S. A., & Welch, A. J. (1990) · IEEE Journal of Quantum Electronics · doi:10.1109/3.64354 · Cited by 2,530
Cited by
Gold Nanorods: From Synthesis and Properties to Biological and Biomedical Applications
Huang, X., Neretina, S., & El‐Sayed, M. A. (2009) · Advanced Materials · doi:10.1002/adma.200802789 · Cited by 1,921
Near-Infrared Resonant Nanoshells for Combined Optical Imaging and Photothermal Cancer Therapy
Gobin, A. M., Lee, M. H., Halas, N. J., James, W. D., Drezek, R. A., & West, J. L. (2007) · Nano Letters · doi:10.1021/nl070610y · Cited by 1,314
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Anisotropic Gold Nanoparticles: Synthesis, Properties, Applications, and Toxicity
Li, N., Zhao, P., & Astruc, D. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201300441 · Cited by 962
Synthesis and Optical Properties of Silver Nanobars and Nanorice
Wiley, B. J., Chen, Y., McLellan, J. M., Xiong, Y., Li, Z.-Y., Ginger, D., & Xia, Y. (2007) · Nano Letters · doi:10.1021/nl070214f · Cited by 655
Metadata
- Authors
- Oldenburg, A. L., Hansen, M. N., Zweifel, D. A., Wei, A., & Boppart, S. A.
- Venue
- Optics Express
- Publisher
- Optica Publishing Group
- Published
- 2006
- Volume
- 14
- Issue
- 15
- Pages
- 6724
- ISSN
- 1094-4087 (ISSN-L)
- OpenAlex
- W2266576679
- Cited by
- 163
- References
- 2
- FWCI
- 11.94
- Type
- journal article
- Language
- en
- Open access
- gold
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- Oldenburg, A. L., Hansen, M. N., Zweifel, D. A., Wei, A., & Boppart, S. A. (2006). Plasmon-resonant gold nanorods as low backscattering albedo contrast agents for optical coherence tomography. Optics Express. https://doi.org/10.1364/oe.14.006724
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