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Analysis of biomolecule detection with optofluidic ring resonator sensors
Open accessAbstract
We theoretically and experimentally analyze the biomolecule detection capability of the liquid core optical ring resonator (LCORR) as a label-free bio/chemical sensor. We first establish a simple and general linear relationship between the LCORR's bulk refractive index sensitivity (BRIS) and its response to molecule deposition onto the surface, which enables us to easily characterize the LCORR sensing performance. Then, biosensing experiments are performed with bovine serum albumin (BSA) and LCORRs of various BRISs. The experimental results are in good agreement with the theoretical prediction. Further analysis shows that the LCORR is capable of detecting BSA below 10 pM with sub-picogram/mm2 mass detection limit.
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Cited by
Lim, J., Shim, J., Kim, I., & Kim, S. (2023) · Photonics Research · doi:10.1364/prj.495076 · Cited by 15
Metadata
- Authors
- Zhu, H., White, I. M., Suter, J. D., Dale, P. S., & Fan, X.
- Venue
- Optics Express
- Publisher
- Optica Publishing Group
- Published
- 2007
- Volume
- 15
- Issue
- 15
- Pages
- 9139
- ISSN
- 1094-4087 (ISSN-L)
- OpenAlex
- W2059255935
- Cited by
- 253
- References
- 0
- FWCI
- 17.32
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhu, H., White, I. M., Suter, J. D., Dale, P. S., & Fan, X. (2007). Analysis of biomolecule detection with optofluidic ring resonator sensors. Optics Express. https://doi.org/10.1364/oe.15.009139
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.