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Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection
Open accessAbstract
We demonstrate a silicon photonic wire waveguide biosensor array chip for the simultaneous monitoring of different molecular binding reactions. The chip is compatible with automated commercial spotting tools and contains a monolithically integrated microfluidic channel for sample delivery. Each array sensor element is a 1.8-mm-long spiral waveguide folded within a 130 microm diameter spot and is incorporated in a balanced Mach-Zehnder interferometer with a near temperature independent response. The sensors are arranged in a 400 microm spacing grid pattern and are addressed through cascaded 1x2 optical power splitters using light from a single input fiber. We demonstrate the real-time monitoring of antibody-antigen reactions using complementary and mismatched immunoglobulin G receptor-analyte pairs and bovine serum albumin. The measured level of detection for each sensor element corresponds to a surface coverage of less than 0.3 pg/mm(2).
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Citations
Cited by
High-Q Optical Sensors for Chemical and Biological Analysis
Luchansky, M. S., & Bailey, R. C. (2012) · Analytical Chemistry · doi:10.1021/ac2029024 · Cited by 288
Thermal independent Silicon-Nitride slot waveguide biosensor with high sensitivity
Tu, X., Song, J., Liow, T.-Y., Park, M. K., Yiying, J. Q., Kee, J. S., Yu, M., & Lo, G.-Q. (2012) · Optics Express · doi:10.1364/oe.20.002640 · Cited by 121
Metadata
- Authors
- Densmore, A., Vachon, M., Xu, D.-X., Janz, S., Ma, R., Li, Y.-H., Lopinski, G., Delâge, A., Lapointe, J., Luebbert, C. C., Liu, Q. Y., Cheben, P., & Schmid, J. H.
- Venue
- Optics Letters
- Publisher
- Optica Publishing Group
- Published
- 2009-11-16
- Volume
- 34
- Issue
- 23
- Pages
- 3598
- ISSN
- 0146-9592 (ISSN-L)
- 1539-4794
- OpenAlex
- W2052089838
- Cited by
- 203
- References
- 0
- FWCI
- 19.27
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection. https://app.cochat.ai/papers/10.1364/ol.34.003598
- The paper
- Densmore, A., Vachon, M., Xu, D.-X., Janz, S., Ma, R., Li, Y.-H., Lopinski, G., Delâge, A., Lapointe, J., Luebbert, C. C., Liu, Q. Y., Cheben, P., & Schmid, J. H. (2009). Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection. Optics Letters. https://doi.org/10.1364/ol.34.003598
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