The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
In vivo label-free photoacoustic microscopy of cell nuclei by excitation of DNA and RNA
Open accessAbstract
Imaging of cell nuclei plays a critical role in cancer diagnosis and prognosis. To image noninvasively cell nuclei in vivo without staining, we developed UV photoacoustic microscopy (UV-PAM), in which 266 nm wavelength UV light excites unlabeled DNA and RNA in cell nuclei to produce photoacoustic waves. We applied UV-PAM to ex vivo imaging of cell nuclei in a mouse lip and a mouse small intestine and to in vivo imaging of the cell nuclei in the mouse skin. The UV-PAM images of unstained cell nuclei match the optical micrographs of the histologically stained cell nuclei. Given intrinsic optical contrast and high spatial resolution, in vivo label-free UV-PAM has potential for unique biological and clinical application.
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Cites
Stoscheck, C. M. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)82008-p · Cited by 1,438 · cited 2×
“DNA and RNA—two major compounds in cell nuclei— strongly absorb UV light around a wavelength of 260 nm [9].”
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Cited by
Photoacoustic tomography: In vivo imaging from organelles to organs
Wang, L. V., & Hu, S. (2012) · Science · doi:10.1126/science.1216210 · Cited by 4,331
Self-citationYao, J., & Wang, L. V. (2013) · Laser & Photonics Reviews · doi:10.1002/lpor.201200060 · Cited by 616
Self-citationSimultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo
Yang, J.-M., Favazza, C., Chen, R., Yao, J., Cai, X., Maslov, K., Zhou, Q., Shung, K. K., & Wang, L. V. (2012) · Nature Medicine · doi:10.1038/nm.2823 · Cited by 429
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Metadata
- Authors
- Yao, D.-K., Maslov, K., Shung, K. K., Zhou, Q., & Wang, L. V.
- Venue
- Optics Letters
- Publisher
- Optica Publishing Group
- Published
- 2010-12-09
- Volume
- 35
- Issue
- 24
- Pages
- 4139
- ISSN
- 0146-9592 (ISSN-L)
- 1539-4794
- OpenAlex
- W2019520586
- Cited by
- 225
- References
- 1
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yao, D.-K., Maslov, K., Shung, K. K., Zhou, Q., & Wang, L. V. (2010). In vivo label-free photoacoustic microscopy of cell nuclei by excitation of DNA and RNA. Optics Letters. https://doi.org/10.1364/ol.35.004139
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