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Surface-Enhanced Raman Spectroscopy in Single Living Cells Using Gold Nanoparticles
Abstract
Ultrasensitive Raman measurements in single living cells are possible through exploiting the effect of surface-enhanced Raman scattering (SERS). Colloidal gold particles (60 nm in size) that are deposited inside cells as “SERS-active nanostructures” result in strongly enhanced Raman signals of the native chemical constituents of the cells. Particularly strong field enhancement can be observed when gold colloidal particles form colloidal clusters. The strongly enhanced Raman signals allow Raman measurements of a single cell in the 400–1800 cm−1 range with 1-μm lateral resolution in relatively short collection times (1 second for one mapping point) using 3–5 mW near-infrared excitation. SERS mapping over a cell monolayer with 1-μm lateral resolution shows different Raman spectra at almost all places, reflecting the very inhomogeneous chemical constitution of the cells. Colloidal gold supported Raman spectroscopy in living cells provides a tool for sensitive and structurally selective detection of native chemicals inside a cell, such as DNA and phenylalanine, and for monitoring their intracellular distributions. This might open up exciting opportunities for cell biology and biomedical studies.
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Citations
Cited by
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Localized Surface Plasmon Resonance Biosensors
Zhao, J., Zhang, X., Yonzon, C. R., Haes, A. J., & Van Duyne, R. P. (2006) · Nanomedicine · doi:10.2217/17435889.1.2.219 · Cited by 508
Theoretical Studies of Plasmonics using Electronic Structure Methods
Morton, S. M., Silverstein, D. W., & Jensen, L. (2011) · Chemical Reviews · doi:10.1021/cr100265f · Cited by 474
Kong, K. V., Lam, Z., Lau, W. K. O., Leong, W. K., & Olivo, M. (2013) · Journal of the American Chemical Society · doi:10.1021/ja409230g · Cited by 173
Erzina, M., Trelin, A., Guselnikova, O., Dvorankova, B., Strnadova, K., Perminova, A., Ulbrich, P., Mares, D., Jerabek, V., Elashnikov, R., et al. (2020) · Sensors and Actuators B: Chemical · doi:10.1016/j.snb.2020.127660 · Cited by 116
Metadata
- Authors
- Kneipp, K., Haka, A. S., Kneipp, H., Badizadegan, K., Yoshizawa, N., Boone, C., Shafer-Peltier, K. E., Motz, J. T., Dasari, R. R., & Feld, M. S.
- Venue
- Applied Spectroscopy
- Publisher
- SAGE Publications
- Published
- 2002-02
- Volume
- 56
- Issue
- 2
- Pages
- 150-154
- ISSN
- 0003-7028 (ISSN-L)
- 1943-3530
- OpenAlex
- W2021980355
- Cited by
- 576
- References
- 0
- FWCI
- 11.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kneipp, K., Haka, A. S., Kneipp, H., Badizadegan, K., Yoshizawa, N., Boone, C., Shafer-Peltier, K. E., Motz, J. T., Dasari, R. R., & Feld, M. S. (2002). Surface-Enhanced Raman Spectroscopy in Single Living Cells Using Gold Nanoparticles. Applied Spectroscopy. https://doi.org/10.1366/0003702021954557
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