The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis
Open accessAbstract
Transforming growth factor-beta1 (TGF-β1), a key member in the TGF-β superfamily, plays a critical role in the development of hepatic fibrosis. Its expression is consistently elevated in affected organs, which correlates with increased extracellular matrix deposition. SMAD proteins have been studied extensively as pivotal intracellular effectors of TGF-β1, acting as transcription factors. In the context of hepatic fibrosis, SMAD3 and SMAD4 are pro-fibrotic, whereas SMAD2 and SMAD7 are protective. Deletion of SMAD3 inhibits type I collagen expression and blocks epithelial-myofibroblast transition. In contrast, disruption of SMAD2 upregulates type I collagen expression. SMAD4 plays an essential role in fibrosis disease by enhancing SMAD3 responsive promoter activity, whereas SMAD7 negatively mediates SMAD3-induced fibrogenesis. Accumulating evidence suggests that divergent miRNAs participate in the liver fibrotic process, which partially regulates members of the TGF-β/SMAD signaling pathway. In this review, we focus on the TGF-β/SMAD and other relative signaling pathways, and discussed the role and molecular mechanisms of TGF-β/SMAD in the pathogenesis of hepatic fibrosis. Moreover, we address the possibility of novel therapeutic approaches to hepatic fibrosis by targeting to TGF-β/SMAD signaling.
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Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives
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TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019
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Metadata
- Authors
- Xu, F., Liu, C., Zhou, D., & Zhang, L.
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 2016-01-08
- Volume
- 64
- Issue
- 3
- Pages
- 157-167
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- OpenAlex
- W2256103742
- Cited by
- 756
- References
- 101
- FWCI
- 30.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Xu, F., Liu, C., Zhou, D., & Zhang, L. (2016). TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis. Journal of Histochemistry & Cytochemistry. https://doi.org/10.1369/0022155415627681
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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