The genetic architecture of parallel armor plate reduction in threespine sticklebacks.
Open accessAbstract
How many genetic changes control the evolution of new traits in natural populations? Are the same genetic changes seen in cases of parallel evolution? Despite long-standing interest in these questions, they have been difficult to address, particularly in vertebrates. We have analyzed the genetic basis of natural variation in three different aspects of the skeletal armor of threespine sticklebacks (Gasterosteus aculeatus): the pattern, number, and size of the bony lateral plates. A few chromosomal regions can account for variation in all three aspects of the lateral plates, with one major locus contributing to most of the variation in lateral plate pattern and number. Genetic mapping and allelic complementation experiments show that the same major locus is responsible for the parallel evolution of armor plate reduction in two widely separated populations. These results suggest that a small number of genetic changes can produce major skeletal alterations in natural populations and that the same major locus is used repeatedly when similar traits evolve in different locations.
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A QTL of lateral plate formation in a low-plated form of the stickleback indicates a significant modification of the reduced plate phenotype (eda locus) with modifying effects within and between loci affecting plate number and size.
“A quantitative trait analysis (QTL) of lateral plate formation in a low-plated form of the stickleback indicates a significant modification of the reduced plate phenotype (eda locus) with modifying effects within and between loci affecting plate number and size [53],[54].”
From Zebrafish eda and edar Mutants Reveal Conserved and Ancestral Roles of Ectodysplasin Signaling in Vertebrates (2008) · cites this paper as [54]
The Results and Discussion (QTL Architecture; page unavailable) identify a major LG 4 locus affecting plate morph, additional unlinked QTL modifying plate number, and QTL affecting plate size. They do not identify the major locus as Eda or establish modifying effects within that locus; the paper says further molecular work is needed to determine whether the LG 4 region contains one or multiple mutations. (LLM, conf=0.84)
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Research works printed but not linked: 20
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Self-citation
- Authors
- Colosimo, P. F., Peichel, C. L., Nereng, K., Blackman, B. K., Shapiro, M. D., Schluter, D., & Kingsley, D. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- Fred Hutch Cancer Center (US)
- University of British Columbia (CA)
- Corresponding author
- Kingsley, David M
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2004-03-30
- Volume
- 2
- Issue
- 5
- Pages
- e109
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- PMC
- PMC385219
- OpenAlex
- W2048619570
- Cited by
- 390
- References
- 0
- Citations by year
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- FWCI
- 10.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- Natural Sciences and Engineering Research Council of Canada
- National Human Genome Research Institute (P50HG002568)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Physical Sciences › Mathematics › Geometry and Topology › Morphological variations and asymmetry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- parallel evolution, Gasterosteus aculeatus, lateral plates, genetic architecture, allelic complementation, gene mapping, natural variation, vertebrate evolution
- MeSH terms
- Alleles, Animals, Animal Structures, Chromosome Mapping, Crosses, Genetic, Biological Evolution, Female, Genetic Complementation Test, Genotype, Male, Models, Genetic, Molecular Sequence Data, Mutation, Phenotype, Selection, Genetic, Genetic Variation, Evolution, Molecular, Smegmamorpha, Quantitative Trait Loci
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