The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Ets1-Related Protein Is a Key Regulator of Vasculogenesis in Zebrafish
Open accessAbstract
During embryonic development, multiple signaling pathways control specification, migration, and differentiation of the vascular endothelial cell precursors, angioblasts. No single gene responsible for the commitment of mesenchymal cells to the angioblast cell fate has been identified as yet. Here we report characterization and functional studies of Etsrp, a novel zebrafish ETS domain protein. etsrp embryonic expression is only restricted to vascular endothelial cells and their earliest precursors. Morpholino knockdown of Etsrp protein function resulted in the complete absence of circulation in zebrafish embryos. Angioblasts in etsrp-morpholino-injected embryos (morphants) failed to undergo migration and differentiation and did not coalesce into functional blood vessels. Expression of all vascular endothelial molecular markers tested was severely reduced in etsrp morphants, whereas hematopoietic markers were not affected. Overexpression of etsrp RNA caused multiple cell types to express vascular endothelial markers. etsrp RNA restored expression of vascular markers in cloche mutants, defective in hematopoietic and endothelial cell formation, arguing that etsrp functions downstream of cloche in angioblast formation. etsrp gene function was also required for endothelial marker induction by the vascular endothelial growth factor (vegf) and stem cell leukemia (scl/tal1). These results demonstrate that Etsrp is necessary and sufficient for the initiation of vasculogenesis.
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Spyropoulos, D. D., Pharr, P. N., Lavenburg, K. R., Jackers, P., Papas, T. S., Ogawa, M., & Watson, D. K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5643-5652.2000 · Cited by 290
Anderson, M. K., Hernandez-Hoyos, G., Diamond, R. A., & Rothenberg, E. V. (1999) · Development · doi:10.1242/dev.126.14.3131 · Cited by 258
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Olsson, A.-K., Dimberg, A., Kreuger, J., & Claesson-Welsh, L. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1911 · Cited by 3,122
Transcriptional Control of Endothelial Cell Development
De Val, S., & Black, B. L. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.014 · Cited by 346
“In zebrafish, the Ets transcription factor Etsrp is the likely ortholog of Etv2 (Pham et al., 2007; Sumanas et al., 2008; Sumanas and Lin, 2006).”
BackgroundJagannathan-Bogdan, M., & Zon, L. I. (2013) · Development · doi:10.1242/dev.083147 · Cited by 346
Combinatorial Regulation of Endothelial Gene Expression by Ets and Forkhead Transcription Factors
De Val, S., Chi, N. C., Meadows, S. M., Minovitsky, S., Anderson, J. P., Harris, I. S., Ehlers, M. L., Agarwal, P., Visel, A., Xu, S.-M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.049 · Cited by 343
Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells
Sabbagh, M. F., Heng, J. S., Luo, C., Castanon, R. G., Nery, J. R., Rattner, A., Goff, L. A., Ecker, J. R., & Nathans, J. (2018) · eLife · doi:10.7554/elife.36187 · Cited by 245
Metadata
- Authors
- Sumanas, S., & Lin, S.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2005-12-20
- Volume
- 4
- Issue
- 1
- Pages
- e10
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2038539380
- Cited by
- 244
- References
- 2
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- gold
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