The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Evolution of Symbiotic Bacteria in the Distal Human Intestine
Open accessAbstract
The adult human intestine contains trillions of bacteria, representing hundreds of species and thousands of subspecies. Little is known about the selective pressures that have shaped and are shaping this community's component species, which are dominated by members of the Bacteroidetes and Firmicutes divisions. To examine how the intestinal environment affects microbial genome evolution, we have sequenced the genomes of two members of the normal distal human gut microbiota, Bacteroides vulgatus and Bacteroides distasonis, and by comparison with the few other sequenced gut and non-gut Bacteroidetes, analyzed their niche and habitat adaptations. The results show that lateral gene transfer, mobile elements, and gene amplification have played important roles in affecting the ability of gut-dwelling Bacteroidetes to vary their cell surface, sense their environment, and harvest nutrient resources present in the distal intestine. Our findings show that these processes have been a driving force in the adaptation of Bacteroidetes to the distal gut environment, and emphasize the importance of considering the evolution of humans from an additional perspective, namely the evolution of our microbiomes.
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Self-citationHost-Bacterial Mutualism in the Human Intestine
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Self-citationAn Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
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Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
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Self-citationGut microbiota in health and disease
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Microbial degradation of complex carbohydrates in the gut
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Metadata
- Authors
- Xu, J., Mahowald, M. A., Ley, R. E., Lozupone, C. A., Hamady, M., Martens, E. C., Henrissat, B., Coutinho, P. M., Minx, P., Latreille, P., Cordum, H., Van Brunt, A., Kim, K., Fulton, R. S., Fulton, L. A., Clifton, S. W., Wilson, R. K., Knight, R. D., & Gordon, J. I.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2007-06-19
- Volume
- 5
- Issue
- 7
- Pages
- e156
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2025134067
- Cited by
- 587
- References
- 9
- FWCI
- 14.37
- Type
- journal article
- Language
- en
- Open access
- gold
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- Xu, J., Mahowald, M. A., Ley, R. E., Lozupone, C. A., Hamady, M., Martens, E. C., Henrissat, B., Coutinho, P. M., Minx, P., Latreille, P., Cordum, H., Van Brunt, A., Kim, K., Fulton, R. S., Fulton, L. A., Clifton, S. W., Wilson, R. K., Knight, R. D., & Gordon, J. I. (2007). Evolution of Symbiotic Bacteria in the Distal Human Intestine. PLoS Biology. https://doi.org/10.1371/journal.pbio.0050156
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