The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Repression of Flowering by the miR172 Target SMZ
Open accessAbstract
A small mobile protein, encoded by the FLOWERING LOCUS T (FT) locus, plays a central role in the control of flowering. FT is regulated positively by CONSTANS (CO), the output of the photoperiod pathway, and negatively by FLC, which integrates the effects of prolonged cold exposure. Here, we reveal the mechanisms of regulation by the microRNA miR172 target SCHLAFMUTZE (SMZ), a potent repressor of flowering. Whole-genome mapping of SMZ binding sites demonstrates not only direct regulation of FT, but also of many other flowering time regulators acting both upstream and downstream of FT, indicating an important role of miR172 and its targets in fine tuning the flowering response. A role for the miR172/SMZ module as a rheostat in flowering time is further supported by SMZ binding to several other genes encoding miR172 targets. Finally, we show that the action of SMZ is completely dependent on another floral repressor, FLM, providing the first direct connection between two important classes of flowering time regulators, AP2- and MADS-domain proteins.
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Cites
Early flower development in Arabidopsis.
Smyth, D. R., Bowman, J. L., & Meyerowitz, E. M. (1990) · The Plant Cell · doi:10.1105/tpc.2.8.755 · Cited by 2,155
Specific effects of microRNAs on the plant transcriptome
Schwab, R., Palatnik, J. F., Riester, M., Schommer, C., Schmid, M., & Weigel, D. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.01.018 · Cited by 1,467
Self-citationHd3a protein is a mobile flowering signal in rice
Tamaki, S., Matsuo, S., Wong, H. L., Yokoi, S., & Shimamoto, K. (2007) · Science · doi:10.1126/science.1141753 · Cited by 1,248
Cited by
The genetic basis of flowering responses to seasonal cues
Andrés, F., & Coupland, G. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3291 · Cited by 1,538
Licausi, F., Ohme‐Takagi, M., & Perata, P. (2013) · New Phytologist · doi:10.1111/nph.12291 · Cited by 1,020
Seasonal and developmental timing of flowering
Amasino, R. (2010) · The Plant Journal · doi:10.1111/j.1365-313x.2010.04148.x · Cited by 894
The multifaceted roles of FLOWERING LOCUS T in plant development
PIN, P. A., & NILSSON, O. (2012) · Plant, Cell & Environment · doi:10.1111/j.1365-3040.2012.02558.x · Cited by 384
Higgins, J. A., Bailey, P. C., & Laurie, D. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010065 · Cited by 280
Metadata
- Authors
- Mathieu, J., Yant, L. J., Mürdter, F., Küttner, F., & Schmid, M.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-07-07
- Volume
- 7
- Issue
- 7
- Pages
- e1000148
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2019707569
- Cited by
- 467
- References
- 3
- FWCI
- 30.60
- Type
- journal article
- Language
- en
- Open access
- gold
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- Mathieu, J., Yant, L. J., Mürdter, F., Küttner, F., & Schmid, M. (2009). Repression of Flowering by the miR172 Target SMZ. PLoS Biology. https://doi.org/10.1371/journal.pbio.1000148
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