Fumarase: A Mitochondrial Metabolic Enzyme and a Cytosolic/Nuclear Component of the DNA Damage Response
Yogev, Ohad, Yogev, Orli, Singer, Esti, Shaulian, Eitan, Goldberg, Michal, Fox, Thomas D., Pines, Ophry·2010·PLoS Biology
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- Oncometabolite fumarate impairs ATR-CHK1 signaling by succinating RPA1 in fumarate hydratase-deficient renal cell carcinoma cellsNian Liu, Changxian Shen, Tingting Zhou, Yu Zhou, Hang Yuan, Hongjie Bi, Yingying Wang, Xinyu Pei, Rui Jun Su, Vijay Trisal et al. · 2026 · Cancer & Metabolism
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- Expansion of Germline Variants in Primary Hyperparathyroidism: Fumarate Hydratase Deficiency as a Cause of Parathyroid AdenomasHussam R Alkaissi, Elías Chuki, Yi Liu, James M. Welch, L Bliss, Niharika Shah, Sunita Kishore Agarwal, William F. Simonds, M. Quezado, Sanaz Sakiani et al. · 2026 · Endocrine Pathology
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- Evolution and metabolite signaling of fumarases (class I and II): origin, function, and subcellular targetingOphir Miller, Dror Jacobi, Liran Carmel, Ophry Pines · 2026 · Molecular Biology and Evolution