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Cited by 238Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital heart defects research

Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis

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Lavado, Alfonso, Lagutin, Oleg V., Chow, Lionel M. L., Baker, Suzanne J., Oliver, Guillermo·2010·PLoS Biology
DOI 10.1371/journal.pbio.1000460PMC PMC2923090
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Abstract

The dentate gyrus has an important role in learning and memory, and adult neurogenesis in the subgranular zone of the dentate gyrus may play a role in the acquisition of new memories. The homeobox gene Prox1 is expressed in the dentate gyrus during embryonic development and adult neurogenesis. Here we show that Prox1 is necessary for the maturation of granule cells in the dentate gyrus during development and for the maintenance of intermediate progenitors during adult neurogenesis. We also demonstrate that Prox1-expressing intermediate progenitors are required for adult neural stem cell self-maintenance in the subgranular zone; thus, we have identified a previously unknown non-cell autonomous regulatory feedback mechanism that controls adult neurogenesis in this region of the mammalian brain. Finally, we show that the ectopic expression of Prox1 induces premature differentiation of neural stem cells.

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References 57 · Cited by 238

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Authors
Lavado, A., Lagutin, O. V., Chow, L. M. L., Baker, S. J., & Oliver, G.
Affiliations
St. Jude Children's Research Hospital (US)
Corresponding author
Oliver, Guillermo
ORCID
Venue
PLoS Biology
Publisher
Public Library of Science (PLoS)
Published
2010-08-17
Volume
8
Issue
8
Pages
e1000460
ISSN
  • 1544-9173 (ISSN-L)
  • 1545-7885
DOI
10.1371/journal.pbio.1000460
PMC
PMC2923090
OpenAlex
W2017559288
Cited by
238
References
57
Citations by year
2026: 13 · 2025: 11 · 2024: 13 · 2023: 13 · 2022: 15 · 2021: 12 · 2020: 17 · 2019: 7 · 2018: 20 · 2017: 17 · 2016: 12 · 2015: 16 · 2014: 19 · 2013: 23 · 2012: 15
FWCI
5.37
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS Biology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
Funders
  • American Lebanese Syrian Associated Charities (CA 21765)
  • National Institutes of Health (5r01hl073402-19, CA21765), R01-HL073402, CA096832)
  • Canadian Institutes of Health Research
  • National Heart, Lung, and Blood Institute (R01-HL073402)
  • National Cancer Institute (CA21765, R01CA135554, P01CA096832, P30CA021765)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords
Prox1, dentate gyrus, granule cell maturation, adult neurogenesis, intermediate progenitor cells, neural stem cells, subgranular zone, homeobox genes, non-cell-autonomous regulation, premature differentiation, hippocampus development
MeSH terms
Prospero-Related Homeobox 1 Protein, Animals, Brain, Cell Differentiation, Female, Neurons, Homeodomain Proteins, Dentate Gyrus, Tumor Suppressor Proteins, Mice, Adult Stem Cells, Neurogenesis, Neural Stem Cells

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