Synthetic Associations Created by Rare Variants Do Not Explain Most GWAS Results

Cited by (170)

Items 101–170 of 170

1. Human Complex Trait Genetics: Lifting the Lid of the Genomics Toolbox - from Pathways to Prediction
   Suzanne J. Rowe, Albert Tenesa · 2012 · Current Genomics
2. Behavior genetics: Past, present, future
   Sara R. Jaffee, Thomas S. Price, Teresa M. Reyes · 2013 · Development and Psychopathology
3. Resequencing Three Candidate Genes for Major Depressive Disorder in a Dutch Cohort
   Eva C. Verbeek, Marianna R. Bevova, Zoltán Bochdanovits, Patrizia Rizzu, Ingrid M. C. Bakker, Tiny Uithuisje, Eco J. C. de Geus, Johannes H. Smit, Brenda W.J.H. Penninx, Dorret Irene Boomsma et al. · 2013 · PLoS ONE
4. Progress from genome-wide association studies and copy number variant studies in epilepsy
   Costin Leu, Antonietta Coppola, Sanjay M. Sisodiya · 2016 · Current Opinion in Neurology
5. Common Disease: Are Causative Alleles Common or Rare?
   Robert Shields · 2011 · PLoS Biology
6. Functional Impact of An ADHD-Associated DIRAS2 Promoter Polymorphism
   Lena Grünewald, Elisabeth Toverud Landaas, Julia M. Geissler, Heike Weber, Carina Quast, Simone Röh, Christoph Schartner, Klaus‐Peter Lesch, Marcel Romanos, Sarah Kittel‐Schneider et al. · 2016 · Neuropsychopharmacology
7. Ultra-rare variants drive substantial cis -heritability of human gene expression
   Ryan D. Hernandez, Lawrence H. Uricchio, Kevin Hartman, Chun Ye, Andrew Dahl, Noah Zaitlen · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
8. Noncoding rare variant associations with blood traits in 166,740 UK Biobank genomes
   Diogo M. Ribeiro, Robin J. Hofmeister, Simone Rubinacci, Olivier Delaneau · 2025 · Nature Genetics
9. Whole Genome Prediction of Bladder Cancer Risk With the Bayesian LASSO
   Evangelina López de Maturana, Stephen J. Chanok, Antoni C. Picornell, Nathaniel Rothman, Jesús Herránz, M. Luz Calle, Montserrat García‐Closas, Gaëlle Marenne, Angela M. Brand, Adonina Tardón et al. · 2014 · Genetic Epidemiology
10. Common variants of T-cells contribute differently to phenotypic variation in sarcoidosis
    Natalia V. Rivera, Michael Hagemann-Jensen, Manuel A. R. Ferreira, Susanna Kullberg, Anders Eklúnd, Nicholas G. Martin, Leonid Padyukov, Johan Grünewald · 2017 · Scientific Reports
11. Heritability Estimation using a Regularized Regression Approach (HERRA): Applicable to continuous, dichotomous or age-at-onset outcome
    Malka Gorfine, Sonja I. Berndt, Jenny C. Chang-Claude, Michael Hoffmeister, Loı̈c Le Marchand, John D. Potter, Martha L. Slattery, Nir Keret, Ulrike Peters, Li Hsu · 2017 · PLoS ONE
12. Dissecting the genetic determinants of hemostasis and thrombosis
    Karl C. Desch · 2015 · Current Opinion in Hematology
13. Understanding Heritability: What it is and What it is Not
    Wendy Johnson, Lars Penke, Frank M. Spinath · 2011 · European Journal of Personality
14. Identifying Plausible Genetic Models Based on Association and Linkage Results: Application to Type 2 Diabetes
    Weihua Guan, Michael Boehnke, Anna Pluzhnikov, Nancy Jean Cox, Laura J. Scott · 2012 · Genetic Epidemiology
15. Genome-Wide Linkage Disequilibrium in Nine-Spined Stickleback Populations
    Ji Hyun Yang, Takahito Shikano, Meng-Hua Li, Juha Merilä · 2014 · G3 Genes Genomes Genetics
16. Potential synthetic associations created by epistasis
    Haijun Liu, Jing Fu, Shuhua Xu, Magnus Nordborg · 2025 · Genome biology
17. Low-density lipoprotein receptor mutations generate synthetic genome-wide associations
    Daniëlla M. Oosterveer, Jorie Versmissen, Joep C. Defesche, Suthesh Sivapalaratnam, Mojgan Yazdanpanah, Monique T Mulder, Leonie van der Zee, André Gerardus Uitterlinden, Cornelia M. van Duijn, Albert Hofman D et al. · 2012 · European Journal of Human Genetics
18. Heritability, Weak Effects, and Rare Variants in Genomewide Association Studies
    François Cambien · 2011 · Clinical Chemistry
19. A rare variant association test in family‐based designs and non‐normal quantitative traits
    Lajmi Lakhal‐Chaieb, Karim Oualkacha, John Brent Richards, Celia M.T. Greenwood · 2015 · Statistics in Medicine
20. Estimating Causal Effects of Genetic Risk Variants for Breast Cancer Using Marker Data from Bilateral and Familial Cases
    Frank Dudbridge, Olivia Fletcher, Kate Walker, Nichola Johnson, Nick Orr, Isabel dos‐Santos‐Silva, Julian Peto · 2012 · Cancer Epidemiology Biomarkers & Prevention
21. Genetic analysis of cassava brown streak disease root necrosis using image analysis and genome-wide association studies
    Leah Nandudu, Christopher Strock, Alex C. Ogbonna, R. Kawuki, Jean‐Luc Jannink · 2024 · Frontiers in Plant Science
22. Common and rare genetic variants show network convergence for a majority of human traits
    Sarah N. Wright, Jane Yang, Trey Ideker · 2026 · EMBO Reports
23. kGWASflow: a modular, flexible, and reproducible Snakemake workflow for k-mers-based GWAS
    Adnan Kivanc Corut, Jason G. Wallace · 2023 · G3 Genes Genomes Genetics
24. Association of the p53 codon 72 polymorphism with clinicopathological characteristics of colorectal cancer through mRNA analysis
    Ligia P. Oliveira, Ignacio López, Érika Maria Monteiro Santos, Paula Tucci, Mónica Marı́n, Fernando Augusto Soares, BENEDITO MAURO ROSSI, Renata de Almeida Coudry · 2013 · Oncology Reports
25. The Genetics of Circulating Resistin Level, A Biomarker for Cardiovascular Diseases, Is Informed by Mendelian Randomization and the Unique Characteristics of African Genomes
    Karlijn A. C. Meeks, Ayo Priscille Doumatey, Amy R. Bentley, Mateus Henrique Gouveia, Guanjie Chen, Jie Zhou, Lin Lei, Adebowale Adeyemo, Charles N. Rotimi · 2020 · Circulation Genomic and Precision Medicine
26. PSMC1 Gene in Parkinson’s Disease
    Pilar Gómez‐Garre, Silvia Jesús, Fátima Carrillo, María Teresa Cáceres‐Redondo, Inmaculada Bernal‐Bernal, Manuel Carballo, Lin Gao, Pablo Mir · 2012 · European Neurology
27. Genetic Epidemiology with a Capital E: Where Will We Be in Another 10 Years?
    Duncan C. Thomas · 2012 · Genetic Epidemiology
28. Have we learnt all we need to know from genetic studies - is genetics over in Alzheimer's disease?
    Harald Juergen Hampel, Simone Lista · 2013 · Alzheimer s Research & Therapy
29. A Novel Approach for the Simultaneous Analysis of Common and Rare Variants in Complex Traits
    Ao Yuan, Guanjie Chen, Yanxun Zhou, Amy R. Bentley, Charles N. Rotimi · 2012 · Bioinformatics and Biology Insights
30. Mapping of Susceptibility Genes for Obesity, Type 2 Diabetes, and the Metabolic Syndrome in Human Populations
    Rector Arya, Sobha Puppala, Vidya S. Farook, Geetha Chittoor, Christopher P. Jenkinson, John Blangero, Daniel Esten Hale, Ravindranath Duggirala, Laura A. Almasy · 2015 · Springer eBooks
31. Computational Assessment of the Expression-Modulating Potential for Non-Coding Variants
    Fangyuan Shi, Yu Wang, Dong Huang, Yu Liang, Nan Liang, Xiaowei Chen, Ge Gao · 2021 · Genomics Proteomics & Bioinformatics
32. Haplotype synthesis analysis reveals functional variants underlying known genome-wide associated susceptibility loci
    André Lacour, David Ellinghaus, Stefan Schreiber, André Franke, Tim Becker · 2016 · Bioinformatics
33. The genetic architecture of neurodevelopmental disorders
    Kevin J. Mitchell · 2014 · bioRxiv (Cold Spring Harbor Laboratory)
34. Transfer Learning Prediction of Early Exposures and Genetic Risk Score on Adult Obesity in Two Minority Cohorts
    Wen‐Ying Chen, Yuxin Liu, Shuo Zhang, Zhou Jiang, Ting Wang, Shuiping Huang, Ping Zeng · 2025 · Prevention Science
35. Joint modeling of whole-genome sequencing data for human height via approximate message passing
    Al Depope, Jakub Bajzík, Marco Mondelli, Matthew R. Robinson · 2026 · Cell Genomics
36. Common genetic variants with fetal effects on birth weight are enriched for proximity to genes implicated in rare developmental disorders
    Robin N. Beaumont, Isabelle K Mayne, Rachel M. Freathy, Caroline Fiona Wright · 2021 · Human Molecular Genetics
37. The Value of Genetic Variation in the Prediction of Obesity
    Ruth J. F. Loos, A. Cecile J.W. Janssens · 2016 · Springer eBooks
38. Inferring causal direction between two traits using R2 with application to transcriptome-wide association studies
    Hui‐ling Liao, Haoran Xue, Wei Pan · 2024 · The American Journal of Human Genetics
39. Gene-Environment Interactions, Stress, and Depression
    Sarah Cohen‐Woods, Kaitlin Nicole Harkess · 2016 · Springer eBooks
40. Discovery and Characterization of Cancer Genetic Susceptibility Alleles
    Stephen Jacob Chanock, Elaine A. Ostrander · 2014 · Elsevier eBooks
41. Pharmacogenetics and Pharmacogenomics
    Daniel W. Nebert, Elliot S. Vesell · 2013 · Elsevier eBooks
42. Approaches for Dissection of the Genetic Basis of Complex Disease Development in Human
    Nicole J., Kiymet Bozaoglu, W. Abdul, Jeremy B. M. Jowett · 2012 · InTech eBooks
43. Gene-Environment Interactions, Stress, and Depression
    Sarah Cohen‐Woods, Kaitlin Nicole Harkess · 2015 · Springer eBooks
44. Discovery and Characterization of Cancer Genetic Susceptibility Alleles
    Stephen Jacob Chanock, Elaine A. Ostrander · 2020 · Elsevier eBooks
45. Genetic susceptibility for inflammatory bowel disease across ethnicities and diseases
    Suzanne van Sommeren · 2019
46. On the contribution of genetic heterogeneity to complex traits
    Haijun Liu, Kelly Swarts, Shuhua Xu, Jianbing Yan, Magnus Nordborg · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
47. Novel extensions of label propagation for biomarker discovery in genomic data
    Matthew E. Stokes · 2014 · D-Scholarship@Pitt (University of Pittsburgh)
48. Genome-Wide Analyses of HIV-1 Host Genetics
    Kimberly Pelak · 2012 · DukeSpace (Duke University)
49. Genetic risk factors for amyotrophic lateral sclerosis : focusing on copy number variation
    Hylke M. Blauw · 2012 · Utrecht University Repository (Utrecht University)
50. Recent Updates in Schizophrenia Genetics
    Hee Jeong Jeong, Byung Dae Lee, Je‐Min Park, Young Min Lee, Eunsoo Moon · 2013 · Korean Journal of Schizophrenia Research
51. Case-Control Association Testing of Common Variants from Sequencing of DNA Pools
    Allan F. McRae, Melinda M. Richter, Penelope A. Lind · 2013 · PLoS ONE
52. Complex Genetic Control of Autoimmune Disease
    Katherine R. Bull, Richard J. Cornall · 2016 · Elsevier eBooks
53. Fine-Mapping of Type 2 Diabetes Loci
    Laura J. Scott, Karen L. Mohlke · 2016 · Springer eBooks
54. Novel insights into the genetic basis of chronic obstructive pulmonary disease
    Josiah E. Radder · 2016 · D-Scholarship@Pitt (University of Pittsburgh)
55. What HaveWe Learned fromGWAS?
    Benjamin F. Voight · 2021 · Springer eBooks
56. Gene-Environment Interactions, Stress, and Depression
    Sarah Cohen‐Woods, Kaitlin Nicole Harkess · 2016 · Springer eBooks
57. Refining the genetic risk of breast cancer with rare haplotypes and pattern mining
    William Letsou, Fan Wang, Wonjong Moon, Cindy Im, Yadav Sapkota, Leslie L. Robison, Yutaka Yasui · 2023 · Life Science Alliance
58. From Hazard Rate to Age-at-Onset Distribution: Mind the Gap
    Nilanjan Chatterjee, Yuzheng Dun · 2023 · Cancer Epidemiology Biomarkers & Prevention
59. Moving from GWAS signals to rare functional variation in inflammatory bowel disease through application of GenePy2 as a potential DNA biomarker
    Guo Cheng, James John Ashton, Andrew R Collins, R Mark Beattie, Sarah Ennis · 2024 · medRxiv
60. Tackling the role of rare functional variation in inflammatory bowel disease through application of GenePy2 as a potential DNA biomarker
    Sarah Ennis, Guo Cheng, James John Ashton, R Mark Beattie, Andrew R Collins · 2024 · Research Square
61. Developmental potential and adaptation
    Mark E. Olson · 2026 · Oxford University Press eBooks
62. Standard adaptation
    Mark E. Olson · 2026 · Oxford University Press eBooks
63. Building adaptationist evo-devo explanations of organismal form
    Mark E. Olson · 2026 · Oxford University Press eBooks
64. Adaptationist Evo-Devo
    Mark E. Olson · 2026
65. Introduction
    Mark E. Olson · 2026 · Oxford University Press eBooks
66. Dedication
    Mark E. Olson · 2026 · Oxford University Press eBooks
67. Glossary
    Mark E. Olson · 2026 · Oxford University Press eBooks
68. Conclusion
    Mark E. Olson · 2026 · Oxford University Press eBooks
69. Evolution and developmental systems
    Mark E. Olson · 2026 · Oxford University Press eBooks
70. Understanding phenotypic plasticity and its role in evolution
    Mark E. Olson · 2026 · Oxford University Press eBooks