MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes
Bujalka, Helena, Koenning, Matthias, Jackson, Stacey, Perreau, Victoria M., Pope, Bernard, Hay, Curtis M., Mitew, Stanlislaw, Hill, Andrew F., Lu, Q. Richard, Wegner, Michael, Srinivasan, Rajini, Svaren, John, Willingham, Melanie, Barres, Ben A., Emery, Ben·2013·PLoS Biology
Cited by (272)
Items 201–272 of 272
- Single-cell multi-omics analysis reveals cooperative transcription factors for gene regulation in oligodendrocytesJerome J. Choi, John P. Svaren, Daifeng Wang · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Korean Red Ginseng and Rb1 restore altered social interaction, gene expressions in the medial prefrontal cortex, and gut metabolites under post-weaning social isolation in miceOh Wook Kwon, Youngja Hwang Park, Dalnim Kim, Hyog Young Kwon, Hyun‐Jeong Yang · 2024 · Journal of Ginseng Research
- Discovery of oligodendrocyte enhancers that regulate Sox10 expressionHongjoo An, Chuandong Fan, Dongkyeong Kim, Huy Bui, Yungki Park · 2025 · PLoS Genetics
- G Protein‐Coupled Receptor Signaling in CNS (Re)MyelinationJack K. McDonald, Sheng Yu Ang, Christopher J. Langmead, Gregory D. Stewart · 2025 · Journal of Neurochemistry
- MYRF Variants in Patients With 46, XY Differences/Disorders of Sex Development and Literature ReviewWei Zhang, Xi Wang, Jiangfeng Mao, Yaqing Cao, Xiaoxia Zhang, Min Nie, Xueyan Wu · 2025 · American Journal of Medical Genetics Part A
- Coordination of Schwann cell myelination and node formation at the transcriptional levelMichael Wegner, Franziska Fröb · 2021 · Neural Regeneration Research
- Transcriptional regulatory network associated with multiple sclerosis pathogenesisYi Ying Cheok, Suhailah Abdullah, Won Feng Wong · 2023 · Elsevier eBooks
- Activation of the Akt Attenuates Ropivacaine-Induced Myelination Impairment in Spinal Cord and Sensory Dysfunction in Neonatal RatsLei Wu, Siwei Wei, Dongjie Pei, Yiyi Yao, Zhen Xiang, Eryou Yu, Zheng Chen, Zhen Du, Shuangquan Qu · 2023 · Molecular Neurobiology
- Correspondence to Rossetti et al.'s review of the phenotypic spectrum associated with haploinsufficiency of MYRFWenmin Sun, Xueshan Xiao, Qingjiong Zhang · 2019 · American Journal of Medical Genetics Part A
- The clinical overlap between cardiac‐urogenital syndrome, Meacham syndrome, and PAGOD syndrome. Report of a new patient with cardiac‐urogenital syndromeDaniela Alves, Miguel Leão · 2020 · American Journal of Medical Genetics Part A
- Myelin pathology in ataxia-telangiectasia is the cell autonomous effect of ATM deficiency in oligodendrocytesTse, Kai-Hei, Cheng, Aifang, Yeung, Sunny Hoi-Sang, Ng, Jia-Nian, Cheng, Gerald Wai-Yeung, Wang, Qingyang, Zhu, Beika, Cui, Yong, Jiang, Liwen, Kofler, Julia et al. · 2021
- Oligodendrocyte lineage cells driven by neuronal activity in selected brain regions are required for episodic memory formationLuendreo P. Barboza, Benjamin Bessières, Omina Nazarzoda, Cristina M. Alberini · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult CNSHannah Y. Collins, Ryan A. Doan, Jiaxing Li, Jason J. Early, Megan Madden, Tyrell Simkins, David Anthony Lyons, Kelly R. Monk, Ben Emery · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Like a G6-nal: transcriptional control of G-protein coupled receptors during oligodendroglial developmentTim Aberle, Michael Wegner · 2024 · Neural Regeneration Research
- The Intranasal Administration of Transferrin‐Loaded Extracellular Vesicles Enhances RemyelinationVanesa Soledad Mattera · 2025 · Journal of Neurochemistry
- Persistent Leukoencephalopathy Following H 1 N 1 Infection Associated With a Novel MYRF Variant (p. G ly735 A sp)Jinghan Hu, Leiyun Huang, Wan Zhu, Min Peng, Qiang Gong, Jing Qian · 2025 · Annals of Clinical and Translational Neurology
- Integrative genomic characterization of the FADS1-2-3 mood disorder risk locus: implications for the role of polyunsaturated fatty acidsDavid Stacey, William R. Reay, Liam J. Veltman, Beben Benyamin, S. Hong Lee, Elina Hyppönen · 2026 · Journal of Affective Disorders
- Extraction et purification de l’ADNAnandika Dhaliwal · 2013 · Materials and Methods
- A shifting adversary: control of pancreatic cancer transcriptomic subtypesCharles J. David · 2022 · Journal of Cancer Metastasis and Treatment
- LY2940094, an NOPR antagonist, promotes oligodendrocyte generation and myelin recovery in an NOPR independent mannerYanhui Duan, Chenyuan Ye, Jingyi Liao, Xin Xie · 2024 · Neurotherapeutics
- MYRF gene mutation leading to coronary artery anomaly combined with 46,XY sex development disorder, a case report and literature reviewJianhua Ding, Zhenyu Lv, Zhen Zhen, Yong Gai, Yanyan Xiao · 2025 · BMC Pediatrics
- Generation and Maturation of Macroglia in the Central Nervous SystemNisha Patro, Ishan Kumar Patro · 2022 · Springer eBooks
- Central nervous system hypomyelination disrupts axonal conduction and behaviour in larval zebrafishMegan Madden, Daumante Šuminaite, Elelbin A. Ortiz, Jason J. Early, Sigrid Koudelka, Matthew R. Livesey, Isaac Henry Bianco, Michael Granato, David Anthony Lyons · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Early Deprivation Impairs Perforant Pathway Connectivity and Contextual Memory in Adolescent Male MiceRafiad Islam, Jordon D. White, Tanzil Mahmud Arefin, Sameet S. Mehta, Xinran Liu, Baruh Polis, Lauryn Giuliano, Sahabuddin Ahmed, Christian Andrew Bowers, Jiangyang Zhang et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Splicing variants in MYRF cause partial loss of function in the retinal pigment epitheliumGabrielle M. Rozumek, Michelle Lynn Brinkmeier, Bin Guan, Su Qing Wang, Catherine A. Tower, Nina T. Yang, Rachel Lim, Lijin Dong, Douglas Ford Hannum, Sayoko Eileen Moroi et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Dual Inhibition of MYRF Cleavage by Its JM Region and PAN-1 CCT Gates Developmental Timing in C. elegansZhimin Xu, Xiaoting Feng, Haochen Lyu, Yong-Hong Yan, Yongqi Zhou, Zhizhi Wang, Fang Bai, Meng‐Qiu Dong, Yingchuan Billy Qi · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Mechanisms of disrupted neurodevelopment after Zika virus infection in infancyVenkata Viswanadh Edara, Sienna M. Freeman, Maureen McGuirk Sampson, Kathryn Moore, Rebecca L. Richardson, Nils Schoof, Divine Burgess, Michelle Lee, Gregory Tharp, Roza Vlasova et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Characterization of transcription factors in plasmodium falciparumYen Hoon Luah · 2014
- [Concept of diabetes and its historical changes].Masato Kasuga · 2012 · PubMed
- MYRFs on the Move to Rewire CircuitsColleen N. McLaughlin, Heather Tarczy Broihier · 2017 · Developmental Cell
- microRNAs in Oligodendrocyte Myelination and Repair in the Central Nervous SystemXianghui Zhao, Haibo Wang, Qing Richard Lu · 2017 · Elsevier eBooks
- Purification de Protéine par chromatographie sur colonneCaroline Ritchie · 2012 · Materials and Methods
- Computational genomics and genetics of developmental disordersHongjian Qi · 2018
- The role of apolipoprotein E in traumatic brain injury as determined by isoform and Abca1 haplodeficiencyEmilie L. Castranio · 2018 · D-Scholarship@Pitt (University of Pittsburgh)
- Myelin plasticity in mouse resilience and susceptibility to psychosocial stress : implications for anxiety disordersMikaela A. Laine · 2021 · Työväentutkimus Vuosikirja
- Evolução molecular do enhancer HACNS1 em primatasGabrielle Azevedo Rizzato · 2020
- Pluripotent stem-cell-derived oligodendrocyte progenitors to model demyelination caused by Theiler’s murine encephalomyelitis virus and other virusesEric C. Freundt, Pavan Rajanahalli · 2021 · Elsevier eBooks
- Methods to Identify Oligodendrocytes and Schwann cells☆Jacqueline Trotter, Khalad Karram · 2015 · Elsevier eBooks
- Faculty Opinions recommendation of Myelinogenic Plasticity of Oligodendrocyte Precursor Cells following Spinal Cord Contusion Injury.Michael George Fehlings · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell CycleRashad Hussain, Wendy B. Macklin · 2017 · Journal of Neuroscience
- 柱层析蛋白质纯化方法学之综述Caroline Ritchie · 2012 · 实验材料和方法
- Ben A. Barres2018 · Society for Neuroscience eBooks
- Essential Function of Transmembrane Transcription Factor MYRF in Promoting Transcription of miRNA lin-4 during C. elegans DevelopmentZhimin Xu, Zhao Wang, Lifang Wang, Yingchuan Billy Qi · 2024 · eLife
- Focal cortical dysplasia type II-dependent maladaptive myelination in the human frontal lobeC. Donkels, Susanne Huber, T. Demerath, C. Scheiwe, M. Shah, M. Heers, H. Urbach, A. Schulze-Bonhage, Marco Prinz, U. Häussler et al. · 2024 · bioRxiv
- Essential Function of Transmembrane Transcription Factor MYRF in Promoting Transcription of miRNA lin-4 during C. elegans DevelopmentZhimin Xu, Zhao Wang, Lifang Wang, Yingchuan Billy Qi · 2024 · eLife
- Anophthalmia, Microphthalmia, and Uveal ColobomaPaige M. Brooks, Brian P. Brooks · 2024 · Elsevier eBooks
- Cardiac-Urogenital Syndrome (CUSC)Linda Z. Rossetti, Daryl A. Scott · 2025 · Springer eBooks
- Orchestrating the neuroglial compartment: Ontogeny and developmental interaction of astrocytes, oligodendrocytes, and microgliaImke M. E. Schuurmans, Annika Mordelt, Lot D. de Witte · 2025 · Handbook of clinical neurology
- Integration of Nuclear Receptors into a Schwann cell Gene Regulatory NetworkRaghu Ramesh, Saniya Khullar, Alena J. Hanson, Seongsik Won, Camila Lopez‐Anido, Daifeng Wang, John P. Svaren · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- PKC-dependent MYRF dysregulation links Aβ pathology to oligodendrocyte, myelin and cognitive alterations in Alzheimer’s diseaseUxue Balantzategi, Adhara Gaminde‐Blasco, Neus Alcañiz, Juanma Ramírez, Rodrigo Senovilla-Ganzo, Nagore Hernández-Pinedo, Mario Fernandez-Ballester, Federico Nicolás Soria, Alerie Guzman de la Fuente, Fernando García‐Moreno et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Additional file 3 of ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiationChen, Lu, Yu, Zhuo, Li Xie, He, Xiaoxiao, Xingmei Mu, Chen, Chiqi, Yang, Wenqian, Tong, Xiaoping, Liu, Junling, Gao, Zhengliang et al. · 2023 · Figshare
- Additional file 1 of Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent miceRafiad Islam, Jordon D. White, Tanzil Mahmud Arefin, Sameet S. Mehta, Xinran Liu, Polis, Baruh, Lauryn Giuliano, Sahabuddin Ahmed, Christian Bowers, Zhang, Jiangyang et al. · 2024 · Figshare
- Additional file 2 of ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiationChen, Lu, Yu, Zhuo, Li Xie, He, Xiaoxiao, Xingmei Mu, Chen, Chiqi, Yang, Wenqian, Tong, Xiaoping, Liu, Junling, Gao, Zhengliang et al. · 2023 · Figshare
- Additional file 1 of ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiationChen, Lu, Yu, Zhuo, Li Xie, He, Xiaoxiao, Xingmei Mu, Chen, Chiqi, Yang, Wenqian, Tong, Xiaoping, Liu, Junling, Gao, Zhengliang et al. · 2023 · Figshare
- MYRF drives heterochronic miRNAs and LIN-42, and amplifies oscillatory programs for stage transitionsZhao Wang, Shiqian Shen, Xiaoting Feng, Di Chen, Qian Bian, Yingchuan Billy Qi · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Reactive OPCs in CNS Injury: From Functional Diversity to Therapeutic TranslationSheng-Nan Wang, Hong Liu, Jiali Li, Yi Yuan, Ziwei Dai, Zhida Lan, Chao Huang, Xiao-lin Wei, Cheng He, Zhi-Da Su et al. · 2026 · Neuroscience Bulletin
- Beyond the Wiring: White Matter as a Dynamic Regulator of Brain Function and DiseaseChenzhao He, Debao Wu, Ailian Du, Liang Zhang · 2026 · Neuroscience Bulletin
- Splicing variants in MYRF cause partial loss of function in the retinal pigment epithelium leading to nanophthalmosGabrielle M. Rozumek, Michelle Lynn Brinkmeier, Bin Guan, Su Qing Wang, Catherine A. Tower, Nina T. Yang, Rachel S. Lim, Dejuan Kong, Daniel Soden, Qitao Zhang et al. · 2026 · JCI Insight
- Dual Inhibition of MYRF Cleavage by Its JM Region and PAN-1 CCT Gates Developmental Timing in C. elegansZhimin Xu, Xiaoting Feng, Haochen Lyu, Yong-Hong Yan, Yongqi Zhou, Zhizhi Wang, Fang Bai, Meng‐Qiu Dong, Yingchuan Billy Qi · 2026 · eLife
- Dual Inhibition of MYRF Cleavage by Its JM Region and PAN-1 CCT Gates Developmental Timing in C. elegansZhimin Xu, Xiaoting Feng, Haochen Lyu, Yong-Hong Yan, Yongqi Zhou, Zhizhi Wang, Fang Bai, Meng‐Qiu Dong, Yingchuan Billy Qi · 2026 · eLife
- The role of Chd7 & Chd8 chromatin remodelers in oligodendrogenesis and (re)myelinationCorentine Marie · 2017 · theses.fr (ABES)
- Régénération spontanée de la myéline dans le cerveau de souris adulte : interactions entre cellules souches, progéniteurs et microglieBéatrice Brousse · 2019 · theses.fr (ABES)
- Etude des conséquences des altérations de la myéline sur les fonctions cognitives à la suite d’un épisode transitoire de démyélinisation chez la souris adulteOcéane Mercier · 2022 · theses.fr (ABES)
- Contribution des neuroblastes dérivés de la zone sous ventriculaire à la régénération de la myéline dans le cerveau de souris adulte : impact des propriétés mécaniques des tissusMarie Falque · 2023 · theses.fr (ABES)
- Transcriptional Heterogeneity of Oligodendrocytes: Molecular Basis of Diversity Across Development, Brain Regions, and Neurological DiseasesShingo Miyata, Shoko Shimizu, Yugo Ishino · 2026 · Neurology International
- Identifying membrane-bound transcriptional regulatory proteins from rare but evolutionarily conserved domain combinationsMuyoung Lee, Yeejin Jang, Qingqing Guo, Ujwal Punyamurtula, Joonhyuk Choi, Jonghwan Kim, Edward M. Marcotte · 2026 · Nucleic Acids Research
- The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice(PTN-PTPRZシグナルはオリゴデンドロサイト分化のためのAFAP1L2依存的PI3K-AKT経路を活性化する:マウスにおけるPTPRZ活性の不活化)Naomi Tanga · Institutional Repositories DataBase (IRDB)
- A Novel MYRF Variant Presenting With Scimitar Syndrome, Hepatopulmonary Fusion, Right‐Sided Congenital Diaphragmatic Hernia, and Uterine DidelphysGul Sher, Samantha Weaver, R. Adwani, Jai Parkash Udassi · 2026 · Case Reports in Pediatrics
- Crosstalk Between Oligodendrocyte Lineage Cells and CNS ‐Resident and Peripheral Immune Cells Governs Demyelination and Remyelination in Multiple SclerosisJoohyun Park, So Yeong Cheon, Fuzheng Guo · 2026 · Glia
- Oligodendrocyte‐Targeted SGK1.1 Inhibition Alleviates White Matter Injury and Cognitive Impairment in Alzheimer's Disease via Modulation of HDAC2 PhosphorylationShiji Deng, Shenghan Gao, Chao Zhou, Zhen Lan, Huiya Li, Jiang Chen, Yuhao Xu, Jiashuo Li, Pinyi Liu, Siyuan Zhang et al. · 2026 · CNS Neuroscience & Therapeutics
- Oligodendrocytes in central nervous system health and diseaseLucy J. Ryan, Véronique E. Miron · 2026 · Cell
- Mechanisms and therapeutic strategies for central and peripheral remyelinationJiangshan Zhan, Juyeon Jo, Carlo D. Cristobal, Da Jeong Jeong, Hwan Tae Park, Hyun Kyoung Lee · 2026 · Progress in Neurobiology