A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis

Snijder, Eric J., Limpens, Ronald W. A. L., de Wilde, Adriaan H., de Jong, Anja W. M., Zevenhoven-Dobbe, Jessika C., Maier, Helena J., Faas, Frank F. G. A., Koster, Abraham J. +1 more·2020·PLOS Biology
DOI 10.1371/journal.pbio.3000715

Cited by (477)

Items 401–477 of 477

  1. Plasma Extracellular Vesicles Derived from Pediatric COVID-19 Patients Modulate Monocyte and T Cell Immune Responses Based on Disease Severity
    Pınar Gür Çetinkaya, Irem Abras, İrem Evcili, Tugce Canavar Yildirim, Yasemin Ceylan, Fehime Kara Eroğlu, Başak Kayaoğlu, Emre Mert İpekoğlu, Ayşegül Akarsu, Muzaffer Yıldırım et al. · 2024 · Immunological Investigations
  2. Dimming the corona: studying SARS-coronavirus-2 at reduced biocontainment level using replicons and virus-like particles
    Grace Neilsen, Asha Maria Mathew, Jose M. Castro, William M. McFadden, Xin Rong Wen, Yee Tsuey Ong, Philip R. Tedbury, Shuiyun Lan, Stefan G. Sarafianos · 2024 · mBio
  3. Examining the feasibility of replacing ORF3a with fluorescent genes to construct SARS-CoV-2 reporter viruses
    Isobel Webb, Maximilian Erdmann, Rachel Milligan, Megan Savage, David A. Matthews, Andrew D. Davidson · 2025 · Journal of General Virology
  4. Scrutinizing Coronaviruses Using Publicly Available Bioinformatic Tools: The Viral Structural Proteins as a Case Study
    Sonia Beeckmans, Edilbert VAN DRIESSCHE · 2021 · Frontiers in Molecular Biosciences
  5. Pathogenesis of covid-19: principles of viral infection and immune response
    Jiří Beneš, Dana Nováková · 2021 · Intervenční a akutní kardiologie
  6. Evidence of mitochondria origin of SARS-CoV-2 double-membrane vesicles: a review.
    Pavel Montes de Oca Balderas · 2022 · F1000Research
  7. Reductionism Ad Absurdum: The Misadventures of Structural Biology in the Time of Coronavirus
    Dmitri Svetlov, Irina Artsimovitch · 2021 · ACS Infectious Diseases
  8. Structural proteins in the mechanisms of betacoronavirus virion assembly
    I. Zaloilo, О. Zaloilo, Yu. Rud, L. Buchatskyi · 2022 · The Ukrainian Biochemical Journal
  9. Structural genomics and immunoinformatics analyses of non-structural protein 6 (NSP6) and its probable role in autophagy
    Niti Yashvardhini, Deepak Kumar Jha, Parimal Kumar Khan, Amit Kumar, Kumar Pranay · 2023 · Biomedical Research and Therapy
  10. How Signaling Games Explain Mimicry at Many Levels: From Viral Epidemiology to Human Sociology
    William Casey, Steven E. Massey, Bud Mishra · 2020 · Research Square
  11. Ultrastructural analysis of nasopharyngeal epithelial cells from patients with SARS-CoV-2 infection
    Karina Lidianne Alcântara Saraiva, Luydson Richardson Silva Vasconcelos, Matheus Filgueira Bezerra, Rodrigo Moraes Loyo, Sinval Pinto Brandão-Filho, Constância Flávia Junqueira Ayres, Regina Célia Bressan Queiroz de Figueiredo, Antonio Pereira‐Neves · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  12. A Coronaviral Pore-Replicase Complex Drives RNA Synthesis in Double Membrane Vesicles
    Anan Chen, Ana‐Mihaela Lupan, Rui Tong Quek, Stefan G. Stanciu, Mihaela Asaftei, George A. Stanciu, Kierra S. Hardy, Taciani de Almeida Magalhães, Pamela A. Silver, Timothy John Mitchison et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  13. Super-Resolution Atlas of SARS-CoV-2 Infection Reveals Protease-Dependent Organelle Maturation, dsRNA Landscapes, and Intracellular Structural Proteins
    Leonid P. Andronov, Mengting Han, Ashwin Balaji, Yan‐Yu Zhu, Lei S. Qi, W. E. Moerner · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  14. MERS-CoV antagonizes PKR activation by inhibiting its condensation at viral replication complexes
    Ebba K. Blomqvist, Nicole R. Bracci, Helena Winstone, J. Monty Watkins, Susan Reich Weiss, James M. Burke · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  15. Distinct RNA engagements define genome import and replication elongation in alphaviruses
    Yaw Bia Tan, Yongbo Luo, Ping Liu, Andres Merits, Dahai Luo · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  16. Novel RT-ddPCR Assays for determining the transcriptional profile of SARS-CoV-2
    Sushama Telwatte, Nitasha Kumar, Albert Vallejo-Gracia, G. Renuka Kumar, Chuanyi Mark Lu, Mélanie Ott, Joseph K. Wong, Steven A. Yukl · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  17. SARS-CoV-2 evasion from ADAR hyper-editing is both genome-encoded and sustained by the virus replication strategy
    Enrico Bortoletto, Paola Venier, Maxwell Shapiro, Andrea Leonardi, Umberto Rosani · 2021 · Research Square
  18. Design and Implementation of Security Device for Patient Health Monitoring Systems
    Anil Kumar Sahu, Neeraj Kumar Misra, D. Praveen Kumar · 2021 · IOP Conference Series Materials Science and Engineering
  19. Cross-reactivity of antibodies from non-hospitalized COVID-19 positive individuals against the native and B.1.351 SARS-CoV-2 spike proteins
    Maryam Hojjat Jodaylami, Abdelhadi Djaïleb, Pierre Ricard, Étienne Lavallée, Stella Cellier-Goetghebeur, Julien Coutu, Matthew Stuible, Christian Gervais, Yves Durocher, Marie‐Pierre Cayer et al. · 2021 · Research Square
  20. Protective Efficacy of a Recombinant Newcastle Disease Virus against Infectious Bronchitis
    Zubair Khalid · 2021
  21. Basis of coronavirus infection, and SARS-CoV-2
    Kazuya Shirato · 2020 · Uirusu
  22. Evidence of mitochondria origin of SARS-CoV-2 double-membrane vesicles: a review.
    Pavel Montes de Oca Balderas · 2021 · F1000Research
  23. Evidence for a long-range RNA-RNA interaction between ORF8 and Spike of SARS-CoV-2
    Okiemute Beatrice Omoru, Filipe Pereira, Sarath Chandra Janga, Amirhossein Manzourolajdad · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  24. Basic Research Reveals the Unique Virologic Features of SARS-CoV-2
    Ryuta Uraki, Seiya Yamayoshi, Yoshihiro Kawaoka · 2021 · TRENDS IN THE SCIENCES
  25. SARS-CoV-2 evasion from ADAR hyper-editing is both genome-encoded and sustained by the virus replication strategy
    Enrico Bortoletto, Paola Venier, Maxwell Shapiro, Andrea Leonardi, Umberto Rosani · 2021 · Research Square
  26. PIKfyve-specific inhibitors restrict replication of multiple human coronaviruses in vitro but not in a murine model of COVID-19
    James Logue, Arup R. Chakraborty, Robert M. Johnson, Girija Goyal, Louis J. Taylor, Lauren Baracco, Marisa E. McGrath, Robert E. Haupt, Melissa J. Rodas, Brooke A. Furlong et al. · 2022 · Research Square
  27. Origen del perfil de mutaciones presente en las secuencias de SARS-CoV-2 en El Salvador
    Carlos Alexander Ortega Pérez, Noé Rigoberto Rivera, Xochitl Sandoval López, Carlos Enrique Hernández Ávila · 2023 · Revista Minerva
  28. Coronavirus endoribonuclease nsp15 induces host cellular protein synthesis shutoff
    Xiao-Qian Gong, Shan Feng, Bo Gao, Shou-Guo Fang, Wen-Lian Weng, Wen-Xiang Xue, Hong-Yan Chu, Yan-Mei Yuan, Yu-Qiang Cheng, Ying-Jie Sun et al. · 2023 · bioRxiv
  29. SARS-CoV-2: Structure, Pathogenesis, and Diagnosis
    Aarthi Goverdhan · 2023 · Elsevier eBooks
  30. Ultrastructural modifications induced by an attenuated SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) in Vero cells
    Lai Wei, Fuyou Che, Shanshan Lu, Mengzhe Li, Xiaoping An, Huahao Fan, Yigang Tong, Lihua Song · 2023 · Research Square
  31. Organelles de réplication du virus de l’hépatite C et du SARS-CoV-2 : étonnantes similitudes et pistes pour des antiviraux de large spectre
    Philippe Roingeard · 2023 · Bulletin de l Académie Nationale de Médecine
  32. Prediction of new likely emergent amino acid point mutations from USA, UK, Italy, France, Brazil, and India SARS-CoV-2 variants: a possible source for more reliable cocktail coronavirus vaccine
    Saganuwan Alhaji Saganuwan · 2024 · RPS Pharmacy and Pharmacology Reports
  33. Characterization of infection and replication of human coronavirus NL63 in vitro as a surrogate for SARS-CoV-2
    Gino Castillo Vilca · 2021
  34. Evaluation of laboratory tests for COVID-19 in South Africa.
    Natasha Samsunder · 2023
  35. The potential of natural products for the suppression of SARS-CoV-2 replication
    Shoichi Sanuki, Mona Tagawa, Rieko Saito, Hikoichiro Maegawa · 2024 · Studies in natural products chemistry
  36. The Accessory Protein ORF3a Hijacks CLCC1 Chloride Channel to Cause ER Dysfunction in Beta-coronavirus Pathogenesis
    Liang Guo, Baoying Huang, Hanzhi Yu, Yi Xu, Lei Wei, Jijie zheng, Yunfeng Li, Di Wu, Peng Zhao, Changcheng Wu et al. · 2024 · Research Square
  37. Synergistic Integration of Multimodal Modeling Approaches for Accelerated COVID-19 Therapeutic Development
    Maitry Goel, Kushal Gupta, Ishal Srivastava, Reema Gabrani · 2025 · Advances in Science, Technology & Innovation/Advances in science, technology & innovation
  38. Scanning Transmission Electron Microscopy Tomography in Virology: 3D Imaging of High-pressure Frozen, Freeze-substituted Samples
    Johannes Georg Wieland, Julia La Roche, Tim Bergner, Rebecca Habisch, Eva Puschmann, Jorge Soza-Ried, Desirée Schütz, Jan Münch, Paul Walther, Martin Dass et al. · 2025 · Journal of Visualized Experiments
  39. Screening-Identified Oxazole-4-Carboxamide KB-2777 Exhibits In Vitro Anti-Coronavirus Activity
    Bud Jung, Woonsung Na, Minjoo Yeom, Jong-Woo Lim, Hai-Quynh Do, Geonhee Jang, Mina Kumari Ban, Jieun Yang, Youngjoo Byun, Daesub Song · 2025 · Pharmaceutics
  40. Viral trafficking: The role of autophagy in the release of virus-loaded extracellular vesicles
    Laura Vipraio Tiberi, Angelica Di Matteo, Fatima Domenica Elisa De Palma, Manuela Lizarralde-Guerrero, Mojgan Djavaheri‐Mergny, Maria Vitale, Filippo Scialó, Lucio Pastore, Maria Chiara Maiuri, Jonathan G. Pol · 2025 · International review of cytology
  41. β-Coronavirus Nsp6 hijacks host ER translocation machineries into viral replication centers
    Kari H. Ecklund, Robert G. Abrisch, Stanley M. Perlman, Gia K. Voeltz · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  42. Modern RNA Quantification Methods: From RT-qPCR to Advanced Microscopy
    Tyrese Boddie, Arianna N. Lacen, Hui-Ting Lee · 2026 · The Journal of Physical Chemistry B
  43. COVID-19 challenges and its therapeutics
    Liguo Liang, Yang Li, Siming Lu, Jialong Wang, Hangping Yao · 2026 · Elsevier eBooks
  44. Integrating replication kinetics and ultrastructural analysis to identify targets for optimizing rVSV bioproduction
    Rebecca Habisch, Johannes Georg Wieland, Jorge Soza-Ried, Clarissa Read, Paul Walther, Peter B. Neubauer, Eva Puschmann, Martin Dass · 2026 · Microbiology Spectrum
  45. Impact of viral membrane oxidation on SARS-CoV-2 spike protein transmembrane anchoring stability
    Maryam Ghasemitarei, Cristina Gyursanszky, Mikko Karttunen, Tapio Ala-Nissilä · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  46. Sichuan pepper, Zanthoxylum bungeanum Maxim., suppresses human coronavirus OC43 infection by inhibiting viral entry and impairing autolysosome accumulation
    Hyeonjeong Park, In Jin Ha, Young-Hee Jin, Sunoh Kwon · 2026 · Chinese Medicine
  47. Insights into SARS-CoV-2 replication control via targeting the host hijacking function of NSP12
    Shirui Fan, Xinyan Long, Wei ZHENG, Zhengrui Xiang, Guangjin Liu, Miao Luo, Yong‐Tang Zheng, Ronghua Luo, Zezhou Yu, Yi Luo et al. · 2026 · Acta Pharmaceutica Sinica B
  48. VAP-A, un gymnaste moléculaire engagé dans les sites de contact membranaire
    Mélody Subra · 2023 · theses.fr (ABES)
  49. Analyse du cycle du SARS-CoV-2 en modèle cellulaire par microscopie électronique à transmission
    Sébastien Eymieux · 2023 · theses.fr (ABES)
  50. The interplay of RNA N7- and 2’O-methylation in viral replication
    Priscila El Kazzi · 2022
  51. Seroepidemiology of emerging viruses in Bolivia
    Lucia Inchauste Jordan · 2023 · theses.fr (ABES)
  52. Pestiviruses utilize pyrimidine metabolism to regulate mitophagy for viral replication
    Bingqian Zhao, Jing Chen, Yan Cheng, Yuhang Li, Linhan Zhong, Jinxia Chen, Xiaoqing Bi, Jishan Bai, Qi Dai, Yinbo Ye et al. · 2026 · Autophagy
  53. Double-membrane-spanning RNA export pores are a conserved feature in nidovirus replication organelles
    Stanley Fronik, Georg Wolff, Ronald W.A.L. Limpens, A van der Meulen - de de Jong, Shawn Q. Zheng, David A. Agard, Abraham J. Koster, Eric J. Snijder, Montserrat Bárcena · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  54. Leveraging ADMET Profiling, Network Pharmacology, and Molecular Docking to Evaluate the Repurposing of Product Nkabinde for COVID-19 Treatment
    Samuel Chima Ugbaja, Siphathimandla Authority Nkabinde, Magugu Nkabinde, Nceba Gqaleni · 2026 · Biomedicines
  55. Coronavirus M protein disperses the trans-Golgi network and inhibits anterograde protein trafficking in the secretory pathway
    Taylor Caddell, Rory P. Mulloy, Jennifer A. Corcoran, Eric S. Pringle, Craig McCormick · 2026 · PLoS Pathogens
  56. Hydroxychloroquine inhibits porcine epidemic diarrhea virus infection by targeting post-attachment stages and virus-induced inflammation in vitro
    Yuwei Zheng, Cai-Yu Chen, Chia-Yu Chang, Chienjin Huang, Hui‐Wen Chang, Min‐Yuan Chia · 2026 · Microbial Pathogenesis
  57. Biomolecular condensation meets membrane biophysics: from interfacial physical principles to emerging therapeutic opportunities
    Agustín Mangiarotti, Ernesto E. Ambroggio, M. Soledad Celej · 2026 · Frontiers in Biophysics
  58. Interferon-gamma induced RNF213 targets nascent double membrane vesicles to inhibit coronavirus primary translation
    Michael A. Tartell, Randa Tissawak, Lennard Voss, Manivel Lodha, Christopher Bianco, Masashi Iwamoto, Daniel Poston, Théodora Hatziioannou, Yiska Weisblum, Paul D. Bieniasz · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  59. It's Complicated: The Pro- and Antiviral Functions of RNA Condensation
    Ebba K. Blomqvist, James M. Burke · 2026 · Annual Review of Virology
  60. A Comprehensive Review of Coronavirus Non-Structure Protein 6 on Structure, Functions, Mechanisms and Its Implications for Antiviral Research
    Yingzhe Yu, Weimei He, Xiaohui Geng, Yulong He, Huapeng Feng, Jian Chen, Jianhong Shu · 2026 · Viruses
  61. Temporal Dynamics of Innate Immune Activation and Viral Interference During Sequential Co-Infection with Influenza A Virus and SARS-CoV-2: Molecular Mechanisms, Clinical Evidence, and Therapeutic Implications
    Jaime Angamarca-Iguago, Juan Marcos Parise-Vasco, Claudia Reytor-González, Jaen Carlos Cagua-Ordoñez, Daniel Simancas‐Racines · 2026 · International Journal of Molecular Sciences
  62. Cell autophagy promotes nucleopolyhedrovirus infection in the fall armyworm
    Xin Qian, Ting Li, Juan Lu, Yang Xue, Dan Wang, Jie Shen · 2026 · Pesticide Biochemistry and Physiology
  63. Uridine cytidine kinase 1 promotes phosphatidylcholine biosynthesis, facilitating SARS-CoV-2 infection
    Guangda Shi, Jaeseung Lee, Smita Bhutda, Zienab Etwebi, Jesse Miller, Kasirajan Ayyanathan, Y L Li, David Nguyen, Yongqing Zhu, Wujuan Zhang et al. · 2026 · Molecular Cell
  64. Impact of viral membrane oxidation on SARS-CoV-2 spike protein transmembrane anchoring stability
    Maryam Ghasemitarei, Cristina Gyursanszky, Mikko Karttunen, Tapio Ala-Nissilä · 2026 · Physical Chemistry Chemical Physics
  65. DABPU-DE targeting host adipose triglyceride lipase provides broad-spectrum anti-coronavirus effects in vitro
    RAGAB FAROUK, Dong Ju Lee, Shaimaa Aboelmagd, Hyung‐Jun Kwon, Seong-Hun Jeong, Seok In Han, Dae‐Eun Cheong, Sieknay Ny, Hae-Rang Seo, Changhee Lee et al. · 2026 · Frontiers in Pharmacology
  66. 4′‐ThioRNA Substitution and Sense‐Strand Segmentation for the Design of Functional Fully Modified siRNAs Targeting SARS‐CoV‐2
    Yuhei Nogi, Jun Tsukimoto, Noriko Saito–Tarashima, Takaaki Koma, Masako Nomaguchi, Noriaki Minakawa · 2026 · Chemistry - A European Journal
  67. Intravenous immunoglobulin recalibrates monocyte responses to abortive SARS-CoV-2 infection across viral variants
    Meryem Alaka, Benoît Desnues · 2026 · Biomedicine & Pharmacotherapy
  68. Serine ubiquitination of the SARS-CoV-2 RdRp by the non-canonical E3 ligase MYCBP2
    RuthMabel Boytz, Jadon Layne, Cleopatra Skerrit-Genelus, Chengjin Ye, Jack Chun-Chieh Hsu, Luis Martínez‐Sobrido, Maudry Laurent-Rolle · 2026 · mSphere
  69. Molecular Mechanisms of Viral Genome Replication During Infection
    Suman Kumar, Bibekananda Bhoi, Neha Sharad, Swati Salila, Nishi, Arti Kumari, Preeti Ranjan, Urvashi Sinha, Maneesh Kumar · 2026 · IntechOpen eBooks
  70. Circulating cholesterol fuels SARS-CoV-2 replication via ORF3a
    Jennifer M. Hayashi, Taha Y. Taha, Irene P. Chen, Rahul K. Suryawanshi, Danielle L. Swaney, Maria McCavitt-Malvido, Mauricio Montaño, Abdullah M. Syed, Mir Mubashir Khalid, Camille R. Simoneau et al. · 2026 · EMBO Reports
  71. The accessory protein ORF3a hijacks the CLCC1 chloride channel to disrupt ER homeostasis in betacoronavirus pathogenesis
    Liang Guo, Baoying Huang, Hanzhi Yu, Yi Xu, Lei Wei, Jijie Zheng, Yuanzhe Li, Di Wu, Peng Zhao, Changcheng Wu et al. · 2026 · Cell Discovery
  72. The organization and dynamics of viral factories
    Kathryn Brittain, Leonardo Martins Delfino, Otávio Henrique Thiemann, Juliana R. Cortines, Kristin N. Parent · 2026 · Journal of Virology
  73. Host soluble inositol phosphate signaling promotes coronavirus replication
    Igor Shats, Huanchen Wang, Yubai Zhou, Chunfang Gu, Adam J. Carr, Carlos M. Guardia, Stephen B. Shears, Robin Evans Stanley, Qisheng Zhang, Raymond D. Blind et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  74. Detection and genomic characterization of an emerging bovine coronavirus in Southwest China
    Yunxin Ren, Wangqing Banma, Yurong Su, Xiji Ye, Cheng Tang, Xi Chen, Yunxin Ren · 2026 · The Veterinary Journal
  75. Coronavirus Exploitation of Ubiquitination and Selective Autophagy to Control Innate Immunity: Mechanisms, Systems Logic, and Therapeutic Opportunities
    Pan Wang, Yuxi Zhao, Yuqiu Yang, Juan Zhang, Junfang Wu, Jiandong Wang · 2026 · Viruses
  76. Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins
    Alvaro de la Cruz‐Potenciano, Miguel Maldonado, María‐José Camarasa, Sonia de Castro · 2026 · ChemMedChem
  77. A Versatile Single-Round SARS-CoV-2 System for Interrogating Antivirals and Host Determinants
    Susiyan Jiang · 2026