Recent developments in yeast aging
Open accessAbstract
In the last decade, research into the molecular determinants of aging has progressed rapidly and much of this progress can be attributed to studies in invertebrate eukaryotic model organisms. Of these, single-celled yeast is the least complicated and most amenable to genetic and molecular manipulations. Supporting the use of this organism for aging research, increasing evidence has accumulated that a subset of pathways influencing longevity in yeast are conserved in other eukaryotes, including mammals. Here we briefly outline aging in yeast and describe recent findings that continue to keep this "simple" eukaryote at the forefront of aging research.
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Caloric restriction extends both medium and maximum lifespan and delays the onset of age-related diseases in yeast, C. elegans, rodents and Rhesus monkeys.
“CR has been shown to extend both medium and maximum lifespan and delay the onset of age-related diseases in a variety of species, including yeast (Kaeberlein et al., 2007), C. elegans (Lee et al., 2006), rodents (Masoro, 2009) and Rhesus monkeys (Colman et al., 2014).”
From Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases (2017) · cites this paper as Kaeberlein et al., 2007
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References 86 · Cited by 239
- Authors
- Kaeberlein, M., Burtner, C. R., & Kennedy, B. K.
- Affiliations
- University of Washington (US)
- Corresponding author
- Kaeberlein, Matt
- Kennedy, Brian K
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2007-05-25
- Volume
- 3
- Issue
- 5
- Pages
- e84
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- PMC
- PMC1877880
- OpenAlex
- W2109134015
- Cited by
- 239
- References
- 86
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 9 · 2023: 9 · 2022: 11 · 2021: 14 · 2020: 14 · 2019: 11 · 2018: 7 · 2017: 12 · 2016: 12 · 2015: 13 · 2014: 11 · 2013: 10 · 2012: 13
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Genetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ellison Medical Foundation
- American Federation for Aging Research
- University of Washington (P30AG013280)
- National Institutes of Health
- National Institute on Aging (R01AG024287, P30AG013280)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- yeast aging, longevity, Saccharomyces cerevisiae, eukaryotic model organism
- MeSH terms
- Animals, Histone Deacetylases, Humans, Saccharomyces cerevisiae, Time Factors, Genome, Fungal, Apoptosis, Oxidative Stress, Sirtuins, Silent Information Regulator Proteins, Saccharomyces cerevisiae, Sirtuin 2
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