The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Targeting the X Chromosome during Spermatogenesis Induces Y Chromosome Transmission Ratio Distortion and Early Dominant Embryo Lethality in Anopheles gambiae
Open accessAbstract
We have exploited the high selectivity of the homing endonuclease I-PpoI for the X-linked Anopheles gambiae 28S ribosomal genes to selectively target X chromosome carrying spermatozoa. Our data demonstrated that in heterozygous males, the expression of I-PpoI in the testes induced a strong bias toward Y chromosome-carrying spermatozoa. Notably, these male mosquitoes also induced complete early dominant embryo lethality in crosses with wild-type females. Morphological and molecular data indicated that all spermatozoa, irrespectively of the inheritance of the transgene, carried a substantial amount of I-PpoI protein that could attack the maternally inherited chromosome X of the embryo. Besides the obvious implications for implementing vector control measures, our data demonstrated the feasibility of generating synthetic sex distorters and revealed the intriguing possibility of manipulating maternally inherited genes using wild-type sperm cells carrying engineered endonucleases.
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Citations
Cites
Argast, G. M., Stephens, K. M., Emond, M. J., & Monnat, R. J. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.1886 · Cited by 127 · cited 1×
“We also screened the genome for sequences matching a number of previously described recognition sequence variants that were identified by in vitro selection to be efficiently cut by I-PpoI [29].”
Method
Metadata
- Authors
- Windbichler, N., Papathanos, P. A., & Crisanti, A.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-12-05
- Volume
- 4
- Issue
- 12
- Pages
- e1000291
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W2086918330
- Cited by
- 182
- References
- 1
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Targeting the X Chromosome during Spermatogenesis Induces Y Chromosome Transmission Ratio Distortion and Early Dominant Embryo Lethality in Anopheles gambiae. https://app.cochat.ai/papers/10.1371/journal.pgen.1000291
- The paper
- Windbichler, N., Papathanos, P. A., & Crisanti, A. (2008). Targeting the X Chromosome during Spermatogenesis Induces Y Chromosome Transmission Ratio Distortion and Early Dominant Embryo Lethality in Anopheles gambiae. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1000291
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
