The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Common Genetic Variation and the Control of HIV-1 in Humans
Open accessAbstract
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
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Principal components analysis corrects for stratification in genome-wide association studies
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Genome-wide association studies for complex traits: consensus, uncertainty and challenges
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Self-citationGenes mirror geography within Europe
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A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1
Fellay, J., Shianna, K. V., Ge, D., Colombo, S., Ledergerber, B., Weale, M., Zhang, K., Gumbs, C., Castagna, A., Cossarizza, A., et al. (2007) · Science · doi:10.1126/science.1143767 · Cited by 1,235
Self-citationIntegrated detection and population-genetic analysis of SNPs and copy number variation
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Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression
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Cited by
The MHC locus and genetic susceptibility to autoimmune and infectious diseases
Matzaraki, V., Kumar, V., Wijmenga, C., & Zhernakova, A. (2017) · Genome biology · doi:10.1186/s13059-017-1207-1 · Cited by 566
Roederer, M., Quaye, L., Mangino, M., Beddall, M. H., Mahnke, Y., Chattopadhyay, P., Tosi, I., Napolitano, L., Terranova Barberio, M., Menni, C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.02.046 · Cited by 296
Fast Principal Component Analysis of Large-Scale Genome-Wide Data
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Metadata
- Authors
- Fellay, J., Ge, D., Shianna, K. V., Colombo, S., Ledergerber, B., Cirulli, E. T., Urban, T. J., Zhang, K., Gumbs, C. E., Smith, J. P., Castagna, A., Cozzi-Lepri, A., De Luca, A., Easterbrook, P., Günthard, H. F., Mallal, S., Mussini, C., Dalmau, J., Martinez-Picado, J., Miro, J. M., Obel, N., Wolinsky, S. M., Martinson, J. J., Detels, R., Margolick, J. B., Jacobson, L. P., Descombes, P., Antonarakis, S. E., Beckmann, J. S., O'Brien, S. J., Letvin, N. L., McMichael, A. J., Haynes, B. F., Carrington, M., Feng, S., Telenti, A., Goldstein, D. B., & NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-12-24
- Volume
- 5
- Issue
- 12
- Pages
- e1000791
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W2153778605
- Cited by
- 419
- References
- 37
- FWCI
- 15.49
- Type
- journal article
- Language
- en
- Open access
- gold
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- Fellay, J., Ge, D., Shianna, K. V., Colombo, S., Ledergerber, B., Cirulli, E. T., Urban, T. J., Zhang, K., Gumbs, C. E., Smith, J. P., Castagna, A., Cozzi-Lepri, A., De Luca, A., Easterbrook, P., Günthard, H. F., Mallal, S., Mussini, C., Dalmau, J., Martinez-Picado, J., . . . NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI). (2009). Common Genetic Variation and the Control of HIV-1 in Humans. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1000791
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
