The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Tsx Produces a Long Noncoding RNA and Has General Functions in the Germline, Stem Cells, and Brain
Open accessAbstract
The Tsx gene resides at the X-inactivation center and is thought to encode a protein expressed in testis, but its function has remained mysterious. Given its proximity to noncoding genes that regulate X-inactivation, here we characterize Tsx and determine its function in mice. We find that Tsx is actually noncoding and the long transcript is expressed robustly in meiotic germ cells, embryonic stem cells, and brain. Targeted deletion of Tsx generates viable offspring and X-inactivation is only mildly affected in embryonic stem cells. However, mutant embryonic stem cells are severely growth-retarded, differentiate poorly, and show elevated cell death. Furthermore, male mice have smaller testes resulting from pachytene-specific apoptosis and a maternal-specific effect results in slightly smaller litters. Intriguingly, male mice lacking Tsx are less fearful and have measurably enhanced hippocampal short-term memory. Combined, our study indicates that Tsx performs general functions in multiple cell types and links the noncoding locus to stem and germ cell development, learning, and behavior in mammals.
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Cites
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The Xist RNA Gene Evolved in Eutherians by Pseudogenization of a Protein-Coding Gene
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Cited by
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lincRNAs: Genomics, Evolution, and Mechanisms
Ulitsky, I., & Bartel, D. P. (2013) · Cell · doi:10.1016/j.cell.2013.06.020 · Cited by 2,608
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X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease
Lee, J. T., & Bartolomei, M. S. (2013) · Cell · doi:10.1016/j.cell.2013.02.016 · Cited by 676
Self-citationRegulation of mammalian cell differentiation by long non‐coding RNAs
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Metadata
- Authors
- Anguera, M. C., Ma, W., Clift, D., Namekawa, S., Kelleher, R. J., & Lee, J. T.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-09-01
- Volume
- 7
- Issue
- 9
- Pages
- e1002248
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W2095381776
- Cited by
- 160
- References
- 4
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- gold
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- Anguera, M. C., Ma, W., Clift, D., Namekawa, S., Kelleher, R. J., & Lee, J. T. (2011). Tsx Produces a Long Noncoding RNA and Has General Functions in the Germline, Stem Cells, and Brain. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1002248
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