The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
How a Retrotransposon Exploits the Plant's Heat Stress Response for Its Activation
Open accessAbstract
Retrotransposons are major components of plant and animal genomes. They amplify by reverse transcription and reintegration into the host genome but their activity is usually epigenetically silenced. In plants, genomic copies of retrotransposons are typically associated with repressive chromatin modifications installed and maintained by RNA-directed DNA methylation. To escape this tight control, retrotransposons employ various strategies to avoid epigenetic silencing. Here we describe the mechanism developed by ONSEN, an LTR-copia type retrotransposon in Arabidopsis thaliana. ONSEN has acquired a heat-responsive element recognized by plant-derived heat stress defense factors, resulting in transcription and production of full length extrachromosomal DNA under elevated temperatures. Further, the ONSEN promoter is free of CG and CHG sites, and the reduction of DNA methylation at the CHH sites is not sufficient to activate the element. Since dividing cells have a more pronounced heat response, the extrachromosomal ONSEN DNA, capable of reintegrating into the genome, accumulates preferentially in the meristematic tissue of the shoot. The recruitment of a major plant heat shock transcription factor in periods of heat stress exploits the plant's heat stress response to achieve the transposon's activation, making it impossible for the host to respond appropriately to stress without losing control over the invader.
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Cites
Floral dip: a simplified method forAgrobacterium‐mediated transformation ofArabidopsis thaliana
Clough, S. J., & Bent, A. F. (1998) · The Plant Journal · doi:10.1046/j.1365-313x.1998.00343.x · Cited by 21,934
Analysis of the genome sequence of the flowering plant Arabidopsis thaliana
Initiative, T. A. G. (2000) · Nature · doi:10.1038/35048692 · Cited by 9,301
Church, G. M., & Gilbert, W. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.7.1991 · Cited by 8,116
GATEWAY™ vectors for Agrobacterium-mediated plant transformation
Karimi, M., Inzé, D., & Depicker, A. (2002) · Trends in Plant Science · doi:10.1016/s1360-1385(02)02251-3 · Cited by 3,635
Czechowski, T., Stitt, M., Altmann, T., Udvardi, M. K., & Scheible, W.-R. (2005) · Plant Physiology · doi:10.1104/pp.105.063743 · Cited by 3,203
The Significance of Responses of the Genome to Challenge
McClintock, B. (1984) · Science · doi:10.1126/science.15739260 · Cited by 2,617
Transposable elements and the epigenetic regulation of the genome
Slotkin, R. K., & Martienssen, R. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2072 · Cited by 2,044
Complexity of the heat stress response in plants
Kotak, S., Larkindale, J., Lee, U., von Koskull-Döring, P., Vierling, E., & Scharf, K.-D. (2007) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2007.04.011 · Cited by 1,344
Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase
Jackson, J. P., Lindroth, A. M., Cao, X., & Jacobsen, S. E. (2002) · Nature · doi:10.1038/nature731 · Cited by 1,251
Heat Shock Transcription Factors: Structure and Regulation
Wu, C. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.002301 · Cited by 1,231 · cited 2×
“However, in contrast to ONSEN, the Drosophila element is transcribed even without heat stress, the expression increase is faster but much less pronounced, and its promoter lacks at least three more copies of the nGAAn sequence required for high affinity interactions with HSFs [30].”
Cited by
Reconsidering plant memory: Intersections between stress recovery, RNA turnover, and epigenetics
Crisp, P. A., Ganguly, D., Eichten, S. R., Borevitz, J. O., & Pogson, B. J. (2016) · Science Advances · doi:10.1126/sciadv.1501340 · Cited by 708
Erdmann, R. M., & Picard, C. L. (2020) · PLOS Genetics · doi:10.1371/journal.pgen.1009034 · Cited by 389
The Arabidopsis thaliana mobilome and its impact at the species level
Quadrana, L., Bortolini Silveira, A., Mayhew, G. F., LeBlanc, C., Martienssen, R. A., Jeddeloh, J. A., & Colot, V. (2016) · eLife · doi:10.7554/elife.15716 · Cited by 334
Genetic and epigenetic control of plant heat responses
Liu, J., Feng, L., Li, J., & He, Z. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00267 · Cited by 301
Bock, D. G., Cai, Z., Elphinstone, C., González-Segovia, E., Hirabayashi, K., Huang, K., Keais, G. L., Kim, A., Owens, G. L., & Rieseberg, L. H. (2023) · Plant Communications · doi:10.1016/j.xplc.2023.100599 · Cited by 84
“It has been speculated that bursts of TE activity, possibly stimulated by abiotic stress, could provide the raw material for rapid adaptation and speciation (McClintock, 1950; Butelli et al., 2012; Cavrak et al., 2014; Zhang and Gao, 2017; Benoit et al., 2019; Wang et al., 2021a).”
Metadata
- Authors
- Cavrak, V. V., Lettner, N., Jamge, S., Kosarewicz, A., Bayer, L. M., & Mittelsten Scheid, O.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-01-30
- Volume
- 10
- Issue
- 1
- Pages
- e1004115
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W2079911234
- Cited by
- 366
- References
- 59
- FWCI
- 27.03
- Type
- journal article
- Language
- en
- Open access
- gold
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