ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease

Helkkula, Pyry; Kiiskinen, Tuomo; Havulinna, Aki S.; Karjalainen, Juha; Koskinen, Seppo; Salomaa, Veikko; Daly, Mark J.; Palotie, Aarno; Surakka, Ida; Ripatti, Samuli; FinnGen

doi:10.1371/journal.pgen.1009501

ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease

Protein-truncating variants (PTVs) affecting dyslipidemia risk may point to therapeutic targets for cardiometabolic disease. Our objective was to identify PTVs that were associated with both lipid levels and the risk of coronary artery disease (CAD) or type 2 diabetes (T2D) and assess their possi…