The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Abnormal Cortical Development after Premature Birth Shown by Altered Allometric Scaling of Brain Growth
Open accessAbstract
BACKGROUND: We postulated that during ontogenesis cortical surface area and cerebral volume are related by a scaling law whose exponent gives a quantitative measure of cortical development. We used this approach to investigate the hypothesis that premature termination of the intrauterine environment by preterm birth reduces cortical development in a dose-dependent manner, providing a neural substrate for functional impairment. METHODS AND FINDINGS: We analyzed 274 magnetic resonance images that recorded brain growth from 23 to 48 wk of gestation in 113 extremely preterm infants born at 22 to 29 wk of gestation, 63 of whom underwent neurodevelopmental assessment at a median age of 2 y. Cortical surface area was related to cerebral volume by a scaling law with an exponent of 1.29 (95% confidence interval, 1.25-1.33), which was proportional to later neurodevelopmental impairment. Increasing prematurity and male gender were associated with a lower scaling exponent (p < 0.0001) independent of intrauterine or postnatal somatic growth. CONCLUSIONS: Human brain growth obeys an allometric scaling relation that is disrupted by preterm birth in a dose-dependent, sexually dimorphic fashion that directly parallels the incidence of neurodevelopmental impairments in preterm infants. This result focuses attention on brain growth and cortical development during the weeks following preterm delivery as a neural substrate for neurodevelopmental impairment after premature delivery.
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Cites
Measuring the thickness of the human cerebral cortex from magnetic resonance images
Fischl, B., & Dale, A. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200033797 · Cited by 5,818
Cognitive and Behavioral Outcomes of School-Aged Children Who Were Born Preterm: A Meta-analysis
Bhutta, A. T., Cleves, M. A., Casey, P. H., Cradock, M. M., & Anand, K. J. S. (2002) · JAMA · doi:10.1001/jama.288.6.728 · Cited by 2,392
Neurologic and Developmental Disability at Six Years of Age after Extremely Preterm Birth
Marlow, N., Wolke, D., Bracewell, M. A., & Samara, M. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa041367 · Cited by 1,901
The Fourth Dimension of Life: Fractal Geometry and Allometric Scaling of Organisms
West, G. B., Brown, J. H., & Enquist, B. J. (1999) · Science · doi:10.1126/science.284.5420.1677 · Cited by 1,718 · cited 2×
“Recent computational work suggests that evolution has optimized these geometrical solutions in terms of microcircuit design, axon length, and areal adjacency [1–3] as well as material transport [4,5].”
BackgroundCross sectional stature and weight reference curves for the UK, 1990.
Freeman, J. V., Cole, T. J., Chinn, S., Jones, P. R., White, E. M., & Preece, M. A. (1995) · Archives of Disease in Childhood · doi:10.1136/adc.73.1.17 · Cited by 1,457
Computer Processing of Line-Drawing Images
Freeman, H. (1974) · ACM Computing Surveys · doi:10.1145/356625.356627 · Cited by 1,368
Neurologic and Developmental Disability after Extremely Preterm Birth
Wood, N. S., Marlow, N., Costeloe, K., Gibson, A. T., & Wilkinson, A. R. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008103430601 · Cited by 1,357
A general model for ontogenetic growth
West, G. B., Brown, J. H., & Enquist, B. J. (2001) · Nature · doi:10.1038/35098076 · Cited by 999
Regional brain volume abnormalities and long-term cognitive outcome in preterm infants
Peterson, B. S. (2000) · JAMA · doi:10.1001/jama.284.15.1939 · Cited by 981
THE BASIC UNIFORMITY IN STRUCTURE OF THE NEOCORTEX
ROCKEL, A. J., HIORNS, R. W., & POWELL, T. P. S. (1980) · Brain · doi:10.1093/brain/103.2.221 · Cited by 896
Cited by
Outcomes for Extremely Premature Infants
Glass, H. C., Costarino, A. T., Stayer, S. A., Brett, C. M., Cladis, F., & Davis, P. J. (2015) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000000705 · Cited by 733
Makropoulos, A., Robinson, E. C., Schuh, A., Wright, R., Fitzgibbon, S., Bozek, J., Counsell, S. J., Steinweg, J., Vecchiato, K., Passerat-Palmbach, J., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.01.054 · Cited by 554
Self-citationMotor and Executive Function at 6 Years of Age After Extremely Preterm Birth
Marlow, N., Hennessy, E. M., Bracewell, M. A., Wolke, D., & for the EPICure Study Group (2007) · Pediatrics · doi:10.1542/peds.2007-0440 · Cited by 434
Brain Injury and Altered Brain Growth in Preterm Infants: Predictors and Prognosis
Kidokoro, H., Anderson, P. J., Doyle, L. W., Woodward, L. J., Neil, J. J., & Inder, T. E. (2014) · Pediatrics · doi:10.1542/peds.2013-2336 · Cited by 395
Development of Executive Function and Attention in Preterm Children: A Systematic Review
Mulder, H., Pitchford, N. J., Hagger, M. S., & Marlow, N. (2009) · Developmental Neuropsychology · doi:10.1080/87565640902964524 · Cited by 388
Metadata
- Authors
- Kapellou, O., Counsell, S. J., Kennea, N., Dyet, L., Saeed, N., Stark, J., Maalouf, E., Duggan, P., Ajayi-Obe, M., Hajnal, J., Allsop, J. M., Boardman, J., Rutherford, M. A., Cowan, F., & Edwards, A. D.
- Venue
- PLoS Medicine
- Publisher
- Public Library of Science (PLoS)
- Published
- 2006-08-01
- Volume
- 3
- Issue
- 8
- Pages
- e265
- ISSN
- 1549-1277 (ISSN-L)
- 1549-1676
- OpenAlex
- W2118802114
- Cited by
- 403
- References
- 44
- FWCI
- 14.92
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kapellou, O., Counsell, S. J., Kennea, N., Dyet, L., Saeed, N., Stark, J., Maalouf, E., Duggan, P., Ajayi-Obe, M., Hajnal, J., Allsop, J. M., Boardman, J., Rutherford, M. A., Cowan, F., & Edwards, A. D. (2006). Abnormal Cortical Development after Premature Birth Shown by Altered Allometric Scaling of Brain Growth. PLoS Medicine. https://doi.org/10.1371/journal.pmed.0030265
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
