The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Multidrug-Resistant Plasmodium vivax Associated with Severe and Fatal Malaria: A Prospective Study in Papua, Indonesia
Open accessAbstract
BACKGROUND: Multidrug-resistant Plasmodium vivax (Pv) is widespread in eastern Indonesia, and emerging elsewhere in Asia-Pacific and South America, but is generally regarded as a benign disease. The aim of the study was to review the spectrum of disease associated with malaria due to Pv and P. falciparum (Pf) in patients presenting to a hospital in Timika, southern Papua, Indonesia. METHODS AND FINDINGS: Data were prospectively collected from all patients attending the outpatient and inpatient departments of the only hospital in the region using systematic data forms and hospital computerised records. Between January 2004 and December 2007, clinical malaria was present in 16% (60,226/373,450) of hospital outpatients and 32% (12,171/37,800) of inpatients. Among patients admitted with slide-confirmed malaria, 64% of patients had Pf, 24% Pv, and 10.5% mixed infections. The proportion of malarial admissions attributable to Pv rose to 47% (415/887) in children under 1 y of age. Severe disease was present in 2,634 (22%) inpatients with malaria, with the risk greater among Pv (23% [675/2,937]) infections compared to Pf (20% [1,570/7,817]; odds ratio [OR] = 1.19 [95% confidence interval (CI) 1.08-1.32], p = 0.001), and greatest in patients with mixed infections (31% [389/1,273]); overall p < 0.0001. Severe anaemia (haemoglobin < 5 g/dl) was the major complication associated with Pv, accounting for 87% (589/675) of severe disease compared to 73% (1,144/1,570) of severe manifestations with Pf (p < 0.001). Pure Pv infection was also present in 78 patients with respiratory distress and 42 patients with coma. In total 242 (2.0%) patients with malaria died during admission: 2.2% (167/7,722) with Pf, 1.6% (46/2,916) with Pv, and 2.3% (29/1260) with mixed infections (p = 0.126). CONCLUSIONS: In this region with established high-grade chloroquine resistance to both Pv and Pf, Pv is associated with severe and fatal malaria particularly in young children. The epidemiology of P. vivax needs to be re-examined elsewhere where chloroquine resistance is increasing.
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Cites
Bacteremia among Children Admitted to a Rural Hospital in Kenya
Berkley, J. A., Lowe, B. S., Mwangi, I., Williams, T., Bauni, E., Mwarumba, S., Ngetsa, C., Slack, M. P. E., Njenga, S., Hart, C. A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa040275 · Cited by 851
The epidemiology of severe malaria in an area of low transmission in Thailand.
Luxemburger, C., Ricci, F., Nosten, F., Raimond, D., Bathet, S., & White, N. J. (1997) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(97)90066-3 · Cited by 299 · cited 1×
“Importantly, whereas mixed infections have been associated previously with a lower risk of severe disease [16,17] and anaemia [18], in our study they were at significantly greater risk than either species alone.”
BackgroundThe epidemiology of malaria in a Karen population on the western border of Thailand.
Luxemburger, C., Thwai, K. L., White, N. J., Webster, H. K., Kyle, D. E., Maelankirri, L., Chongsuphajaisiddhi, T., & Nosten, F. (1996) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(96)90102-9 · Cited by 233
Carrara, V. I., Sirilak, S., Thonglairuam, J., Rojanawatsirivet, C., Proux, S., Gilbos, V., Brockman, A., Ashley, E. A., McGready, R., Krudsood, S., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030183 · Cited by 146
Cited by
White, N. J., Pukrittayakamee, S., Hien, T. T., Faiz, M. A., Mokuolu, O. A., & Dondorp, A. M. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60024-0 · Cited by 1,123
Evidence and Implications of Mortality Associated with Acute Plasmodium vivax Malaria
Baird, J. K. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00074-12 · Cited by 398
Severe Plasmodium vivax Malaria: A Report on Serial Cases from Bikaner in Northwestern India
Kochar, D. K., Das, A., Kochar, S. K., Saxena, V., Sirohi, P., Garg, S., Kochar, A., Khatri, M. P., & Gupta, V. (2009) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2009.80.194 · Cited by 398
CLINICAL ASPECTS OF UNCOMPLICATED AND SEVERE MALARIA
Bartoloni, A., & Zammarchi, L. (2012) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2012.026 · Cited by 304
On the Cytoadhesion of Plasmodium vivax –Infected Erythrocytes
Carvalho, B. O., Lopes, S. C. P., Nogueira, P. A., Orlandi, P. P., Bargieri, D. Y., Blanco, Y. C., Mamoni, R., Leite, J. A., Rodrigues, M. M., Soares, I. S., et al. (2010) · The Journal of Infectious Diseases · doi:10.1086/654815 · Cited by 299
Metadata
- Authors
- Tjitra, E., Anstey, N. M., Sugiarto, P., Warikar, N., Kenangalem, E., Karyana, M., Lampah, D. A., & Price, R. N.
- Venue
- PLoS Medicine
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-06-17
- Volume
- 5
- Issue
- 6
- Pages
- e128
- ISSN
- 1549-1277 (ISSN-L)
- 1549-1676
- OpenAlex
- W2152507925
- Cited by
- 611
- References
- 4
- FWCI
- 46.80
- Type
- journal article
- Language
- en
- Open access
- gold
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- Tjitra, E., Anstey, N. M., Sugiarto, P., Warikar, N., Kenangalem, E., Karyana, M., Lampah, D. A., & Price, R. N. (2008). Multidrug-Resistant Plasmodium vivax Associated with Severe and Fatal Malaria: A Prospective Study in Papua, Indonesia. PLoS Medicine. https://doi.org/10.1371/journal.pmed.0050128
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