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Children Are Not Just Small Adults: The Urgent Need for High-Quality Trial Evidence in Children
Open accessAbstract
Terry Klassen and colleagues discuss a new study examining whether children and adults with drug-resistant partial epilepsy respond differently to antiepileptic drugs.
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“Of the included studies, 5 were pilot trials,37,38,39,40,43 with insufficient power to detect small treatment effect sizes.”
From Safety Planning Interventions for Suicide Prevention in Children and Adolescents: A Systematic Review and Meta-Analysis (2025) · cites this paper as [38]
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“A differential effectiveness of treatment by patient age has similarly been noted for other interventions, including pharmacological treatments, with potentially harmful effects for pediatric populations48,49”
From Safety Planning Interventions for Suicide Prevention in Children and Adolescents: A Systematic Review and Meta-Analysis (2025) · cites this paper as [49]
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“SI was designated as a primary outcome in zero studies and designated as a secondary outcome in 3 studies.35,38,40”
From Safety Planning Interventions for Suicide Prevention in Children and Adolescents: A Systematic Review and Meta-Analysis (2025) · cites this paper as [38]
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“In controlled trials with children and adolescents,35,38,39,40,42,43,44 control conditions were often vaguely defined and sometimes involved elements of safety planning to varying degrees, although results were consistent whether these studies were removed (Figure 2) or included (eFigure in Supplement 1).”
From Safety Planning Interventions for Suicide Prevention in Children and Adolescents: A Systematic Review and Meta-Analysis (2025) · cites this paper as [38]
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Metadata
- Authors
- Klassen, T. P., Hartling, L., Craig, J. C., & Offringa, M.
- Affiliations
- University of Alberta (CA)
- The University of Sydney (AU)
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Klassen, Terry P
- Venue
- PLoS Medicine
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-08-12
- Volume
- 5
- Issue
- 8
- Pages
- e172
- ISSN
- 1549-1277 (ISSN-L)
- 1549-1676
- PMC
- PMC2504487
- OpenAlex
- W2133984258
- Cited by
- 209
- References
- 17
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 14 · 2023: 17 · 2022: 13 · 2021: 12 · 2020: 9 · 2019: 11 · 2018: 10 · 2017: 19 · 2016: 7 · 2015: 10 · 2014: 13 · 2013: 6 · 2012: 12
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Keywords
- pediatric clinical trials, drug-resistant epilepsy, focal epilepsy, antiepileptic drugs, children versus adults, epilepsy treatment
- MeSH terms
- Adult, Child, Clinical Trials as Topic, Epilepsy, Humans, Placebos
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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