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Cited by 59Gestational Diabetes Research and ManagementDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and Research

Consequences of Gestational Diabetes in an Urban Hospital in Viet Nam: A Prospective Cohort Study

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Hirst, Jane E., Tran, Thach S., Do, My An T., Morris, Jonathan M., Jeffery, Heather E.·2012·PLoS Medicine
DOI 10.1371/journal.pmed.1001272PMC PMC3404117
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Abstract

BACKGROUND: Gestational diabetes mellitus (GDM) is increasing and is a risk for type 2 diabetes. Evidence supporting screening comes mostly from high-income countries. We aimed to determine prevalence and outcomes in urban Viet Nam. We compared the proposed International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criterion, requiring one positive value on the 75-g glucose tolerance test, to the 2010 American Diabetes Association (ADA) criterion, requiring two positive values. METHODS AND FINDINGS: We conducted a prospective cohort study in Ho Chi Minh City, Viet Nam. Study participants were 2,772 women undergoing routine prenatal care who underwent a 75-g glucose tolerance test and interview around 28 (range 24-32) wk. GDM diagnosed by the ADA criterion was treated by local protocol. Women with GDM by the IADPSG criterion but not the ADA criterion were termed "borderline" and received standard care. 2,702 women (97.5% of cohort) were followed until discharge after delivery. GDM was diagnosed in 164 participants (6.1%) by the ADA criterion, 550 (20.3%) by the IADPSG criterion. Mean body mass index was 20.45 kg/m(2) in women with out GDM, 21.10 in women with borderline GDM, and 21.81 in women with GDM, p<0.001. Women with GDM and borderline GDM were more likely to deliver preterm, with adjusted odds ratios (aORs) of 1.49 (95% CI 1.16-1.91) and 1.52 (1.03-2.24), respectively. They were more likely to have clinical neonatal hypoglycaemia, aORs of 4.94 (3.41-7.14) and 3.34 (1.41-7.89), respectively. For large for gestational age, the aORs were 1.16 (0.93-1.45) and 1.31 (0.96-1.79), respectively. There was no significant difference in large for gestational age, death, severe birth trauma, or maternal morbidity between the groups. Women with GDM underwent more labour inductions, aOR 1.51 (1.08-2.11). CONCLUSIONS: Choice of criterion greatly affects GDM prevalence in Viet Nam. Women with GDM by the IADPSG criterion were at risk of preterm delivery and neonatal hypoglycaemia, although this criterion resulted in 20% of pregnant women being positive for GDM. The ability to cope with such a large number of cases and prevent associated adverse outcomes needs to be demonstrated before recommending widespread screening. Please see later in the article for the Editors' Summary.

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Authors
Hirst, J. E., Tran, T. S., Do, M. A. T., Morris, J. M., & Jeffery, H. E.
Affiliations
  • The University of Sydney (AU)
  • Hung Vuong Hospital (VN)
Corresponding author
Hirst, Jane E.
ORCID
Venue
PLoS Medicine
Publisher
Public Library of Science (PLoS)
Published
2012-07-24
Volume
9
Issue
7
Pages
e1001272
ISSN
  • 1549-1277 (ISSN-L)
  • 1549-1676
DOI
10.1371/journal.pmed.1001272
PMC
PMC3404117
OpenAlex
W2049969187
Cited by
59
References
51
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 5 · 2021: 7 · 2020: 2 · 2019: 3 · 2018: 9 · 2017: 6 · 2016: 4 · 2015: 1 · 2014: 7 · 2013: 3 · 2012: 2
FWCI
5.02
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
gestational diabetes mellitus, IADPSG criteria, ADA diagnostic criteria, preterm birth, neonatal hypoglycemia, large for gestational age, labor induction, maternal morbidity, type 2 diabetes risk, body mass index, Vietnam, Ho Chi Minh City, prenatal care
MeSH terms
Adult, Blood Glucose, Female, Follow-Up Studies, Glucose Tolerance Test, Hospitals, Urban, Humans, Pregnancy, Pregnancy Outcome, Prospective Studies, Vietnam, Prevalence, Survival Analysis, Diabetes, Gestational

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