The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Limited Dengue Virus Replication in Field-Collected Aedes aegypti Mosquitoes Infected with Wolbachia
Open accessAbstract
Introduction Dengue is one of the most widespread mosquito-borne diseases in the world. The causative agent, dengue virus (DENV), is primarily transmitted by the mosquito Aedes aegypti, a species that has proved difficult to control using conventional methods. The discovery that A. aegypti transinfected with the wMel strain of Wolbachia showed limited DENV replication led to trial field releases of these mosquitoes in Cairns, Australia as a biocontrol strategy for the virus. Methodology/Principal Findings Field collected wMel mosquitoes that were challenged with three DENV serotypes displayed limited rates of body infection, viral replication and dissemination to the head compared to uninfected controls. Rates of dengue infection, replication and dissemination in field wMel mosquitoes were similar to those observed in the original transinfected wMel line that had been maintained in the laboratory. We found that wMel was distributed in similar body tissues in field mosquitoes as in laboratory ones, but, at seven days following blood-feeding, wMel densities increased to a greater extent in field mosquitoes. Conclusions/Significance Our results indicate that virus-blocking is likely to persist in Wolbachia-infected mosquitoes after their release and establishment in wild populations, suggesting that Wolbachia biocontrol may be a successful strategy for reducing dengue transmission in the field.
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Cites
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Self-citationThe wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations
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Cited by
Pérez-Castro, R., Castellanos, J. E., Olano, V. A., Matiz, M. I., Jaramillo, J. F., Vargas, S. L., Sarmiento, D. M., Stenström, T. A., & Overgaard, H. J. (2016) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760150363 · Cited by 86
Meta-analysis of studies on chemical, physical and biological agents in the control of Aedes aegypti
Lima, E. P., Goulart, M. O. F., & Rolim Neto, M. L. (2015) · BMC Public Health · doi:10.1186/s12889-015-2199-y · Cited by 72
Caragata, E. P., Pais, F. S., Baton, L. A., Silva, J. B. L., Sorgine, M. H. F., & Moreira, L. A. (2017) · BMC Genomics · doi:10.1186/s12864-016-3441-4 · Cited by 55
Metadata
- Authors
- Frentiu, F. D., Zakir, T., Walker, T., Popovici, J., Pyke, A. T., van den Hurk, A., McGraw, E. A., & O'Neill, S. L.
- Venue
- PLoS Neglected Tropical Diseases
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-02-20
- Volume
- 8
- Issue
- 2
- Pages
- e2688
- ISSN
- 1935-2735
- OpenAlex
- W2069937826
- Cited by
- 344
- References
- 33
- Type
- dataset
- Language
- en
- Open access
- green
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- Frentiu, F. D., Zakir, T., Walker, T., Popovici, J., Pyke, A. T., van den Hurk, A., McGraw, E. A., & O'Neill, S. L. (2014). Limited Dengue Virus Replication in Field-Collected Aedes aegypti Mosquitoes Infected with Wolbachia. PLoS Neglected Tropical Diseases. https://doi.org/10.1371/journal.pntd.0002688
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