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Efficacy and Safety of Praziquantel, Tribendimidine and Mebendazole in Patients with Co-infection of Clonorchis sinensis and Other Helminths
Open accessAbstract
BACKGROUND: Both tribendimidine and mebendazole are broad-spectrum drugs for anti-intestinal nematodes. We aim to assess the efficacy and safety of tribendimidine and mebendazole in patients with co-infection of Clonorchis sinensis and other helminths. METHOD: We performed a randomized open-label trial in Qiyang, People's Republic of China. Eligible participants were randomly assigned to one of four groups: (i) a single dose of 400 mg tribendimidine, (ii) 200 mg tribendimidine twice daily, (iii) 75 mg/kg praziquantel divided in four doses within 2 days, and (iv) a single dose of 400 mg mebendazole. Cure rates and egg reduction rates were assessed, and adverse events were monitored after treatments. Uncured patients accepted the second treatment with the same drugs after the first treatment. RESULTS: 156 patients were eligible for the study. Results from the first treatment showed that the cure rates of single-dose tribendimidine and praziquantel against C. sinensis were 50% and 56.8%, respectively; the single-dose tribendimidine achieved the cure rate of 77.8% in the treatment for hookworm, which was significantly higher than that of praziquantel; Low cure rates were obtained in the treatment of single-dose tribendimidine against Ascaris lumbricoides and Trichuris trichiura (28.6% and 23.1%). Results of the second treatment illustrated the cure rates of tribendimidine and praziquantel against C. sinensis were 78.1% and 75%, respectively. Most adverse events were mild and transient. Adverse events caused by tribendimidine were significantly less than praziquantel. CONCLUSION: Single-dose tribendimidine showed similar efficacy against C. sinensis as praziquantel with less adverse events, and achieved significantly higher cure rate in the treatment for hookworm than those of praziquantel and mebendazole. Low cure rates, which were still higher than other drugs, were obtained in the treatment of single-dose tribendimidine against Ascaris lumbricoides and Trichuris trichiura. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN55086560.
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“A single dose of mebendazole (100 mg) was ineffective against C. sinensis infection [18]”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [18]
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Citations
Cites
Sample size of 12 per group rule of thumb for a pilot study
Julious, S. A. (2005) · Pharmaceutical Statistics · doi:10.1002/pst.185 · Cited by 3,068
Fish-borne parasitic zoonoses: Status and issues
Chai, J.-Y., Murrell, K. D., & Lymbery, A. J. (2005) · International Journal for Parasitology · doi:10.1016/j.ijpara.2005.07.013 · Cited by 794
Keiser, J., & Utzinger, J. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00012-09 · Cited by 629
Clonorchiasis: a key foodborne zoonosis in China
Lun, Z., Gasser, R. B., Lai, D., Li, A., Zhu, X., Yu, X.-B., & Fang, Y. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)01252-6 · Cited by 553
Rim, H.-J. (2005) · Journal of Helminthology · doi:10.1079/joh2005300 · Cited by 280
The global epidemiology of clonorchiasis and its relation with cholangiocarcinoma
Qian, M., Chen, Y.-D., Liang, S., Yang, G.-J., & Zhou, X. (2012) · Infectious Diseases of Poverty · doi:10.1186/2049-9957-1-4 · Cited by 185
Self-citationControl of foodborne trematode infections. Report of a WHO Study Group
Rollinson, D. (1995) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(95)90463-8 · Cited by 174
Programmes, partnerships, and governance for elimination and control of neglected tropical diseases
Liese, B. H., Rosenberg, M. L., & Schratz, A. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61749-9 · Cited by 165
[A national survey on current status of the important parasitic diseases in human population].
(2005) · PubMed · Cited by 160
Immunological and molecular diagnosis of cysticercosis
Rodríguez, S., Wilkins, P. P., & Dorny, P. (2012) · Pathogens and Global Health · doi:10.1179/2047773212y.0000000048 · Cited by 157
Control of foodborne trematode infections report of a who study group
Prociv, P. (1996) · International Journal for Parasitology · doi:10.1016/s0020-7519(96)90026-0 · Cited by 157
Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China
Xiao, S.-H., Hui-Ming, W., Tanner, M., Utzinger, J., & Wang, C. (2005) · Acta Tropica · doi:10.1016/j.actatropica.2005.01.013 · Cited by 145
Self-citationKeiser, J., & Utzinger, J. (2007) · Trends in Parasitology · doi:10.1016/j.pt.2007.07.012 · Cited by 126
Hu, Y., Xiao, S.-H., & Aroian, R. V. (2009) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000499 · Cited by 106
Self-citationSoukhathammavong, P. A., Odermatt, P., Sayasone, S., Vonghachack, Y., Vounatsou, P., Hatz, C., Akkhavong, K., & Keiser, J. (2010) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(10)70250-4 · Cited by 84
Time to tackle clonorchiasis in China
Qian, M., Chen, Y.-D., & Yan, F. (2013) · Infectious Diseases of Poverty · doi:10.1186/2049-9957-2-4 · Cited by 67
Efficacy and Safety of Tribendimidine Against Clonorchis sinensis
Qian, M., Yap, P., Yang, Y., Liang, H., Jiang, Z.-H., Li, W., Tan, Y.-G., Zhou, H., Utzinger, J., Zhou, X., et al. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis1011 · Cited by 62
Self-citationQian, M., Chen, Y.-D., Fang, Y., Xu, L.-Q., Zhu, T.-J., Tan, T., Zhou, C., Wang, G., Jia, T.-W., Yang, G.-J., et al. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001377 · Cited by 46
Self-citationAnalysis of the results of two nationwide surveys on Clonorchis sinensis infection in China.
Chen, Y. D., Zhou, C., & Xu, L. (2012) · PubMed · doi:10.3967/0895-3988.2012.02.006 · Cited by 36
Self-citationUtzinger, J., Vounatsou, P., N'Goran, E. K., Tanner, M., & Booth, M. (2002) · International Journal for Parasitology · doi:10.1016/s0020-7519(02)00012-7 · Cited by 31
Clinical study evaluating efficacy of praziquantel in clonorchiasis
Yangco, B. G., Lerma, C. D., Lyman, G. H., & Price, D. L. (1987) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.31.2.135 · Cited by 30
Metabolism and Disposition of Tribendimidine and Its Metabolites in Healthy Chinese Volunteers
Yuan, G., Xu, J., Qu, T., Wang, B., Zhang, R., Wei, C., & Guo, R. (2010) · Drugs in R&D · doi:10.1007/bf03259778 · Cited by 27
Maleewong, W., Intapan, P. M., Wongwajana, S., Sitthithaworn, P., Pipitgool, V., Wongkham, C., & Daenseegaew, W. (1992) · PubMed · Cited by 27
Xiao, S.-H., Xue, J., Xu, L.-L., Zhang, Y.-N., & Qiang, H.-Q. (2010) · Parasitology Research · doi:10.1007/s00436-010-2187-1 · Cited by 26
Self-citationThe in vitro and in vivo effect of tribendimidine and its metabolites against Clonorchis sinensis
Xiao, S.-H., Xue, J., Xu, L., Zheng, Q., Qiang, H.-Q., & Zhang, Y. (2009) · Parasitology Research · doi:10.1007/s00436-009-1579-6 · Cited by 21
Self-citationZhang, J., Xiao, S.-H., Wu, Z., Qiu, D., Wang, S.-H., Wang, S., & Wang, C. (2008) · PubMed · Cited by 20
Self-citationXiao, S.-H., Wu, Z., Zhang, J., Wang, S., Wang, S.-H., Qiu, D., & Wang, C. (2007) · PubMed · Cited by 18
Self-citationCurrent status and challenge of Human Parasitology teaching in China
Peng, H., Zhang, C., Wang, C., & Chen, X. (2012) · Pathogens and Global Health · doi:10.1179/2047773212y.0000000040 · Cited by 17
Gui-yan, Y., Benjie, W., Chunmin, W., Zhang, R., & Ruichen, G. (2008) · Chromatographia · doi:10.1365/s10337-008-0657-8 · Cited by 14
Rim, H. J., Lee, Y. M., Lee, J. S., & Joo, K. H. (1982) · Korean Journal of Parasitology · doi:10.3347/kjp.1982.20.1.1 · Cited by 11
ER;, F. P. C. W. F. C. H. P. Y. C. C. K. C., Wu, C., Huang, P., & Yen, C. (2005) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/s1607-551x(09)70149-4 · Cited by 10
Xiao, S.-H., Xue, J., Tanner, M., Zhang, Y., Keiser, J., Utzinger, J., Qiang, H.-Q., & Liu, X. (2008) · PubMed · Cited by 9
Self-citationXue, J., Xu, L., Qiang, H.-Q., Zhang, Y., & Xiao, S.-H. (2009) · PubMed · Cited by 8
Self-citationCompare the Efficacy of Two Antiparasitic Drugs against Clonorchiasis
Chen, X. (2006) · Journal of Tropical Medicine · Cited by 5
[In vitro effect of seven anthelmintic agents against adult Clonorchis sinensis].
Xu, L., Xue, J., Zhang, Y., Qiang, H.-Q., & Xiao, S.-H. (2011) · PubMed · Cited by 5
Self-citation[Effect of community intervention model of clonorchiasis in Zhaoyuan County].
Ji, Z., Ge, T., Yuan, S., Li, X.-Z., Liu, G., & Tang, L. (2012) · PubMed · Cited by 4
[Survey of clonorchiasis in Fuyu County in 2009].
Qiang, Y., Yang, F., Ben-he, W., Shu-Ya, W., & Shu-Hua, Z. (2011) · PubMed · Cited by 2
Huang, X., Cai, W., & Ma, Q. (1999) · PubMed · Cited by 2
Hu, X., Lin, S., ChongJing, T., Liu, J., Chen, D., Wang, S., Wang, C., & Zhang, J. (2009) · Journal of Pathogen Biology · Cited by 1
Research works printed but not linked: 5
- DL Chen, 1997, Clinical observation on treatment of 150 cases of Clonorchiasis with praziquantel, J Pract Parasit Dis, 5, 28
- FN Xu, 1986, Comparative study on different dosage-schedules of praziquantel in treating 376 cases of Clonorchis sinensis infection, Anhui J Med, 7, 33
- XX Huang, 1999, Comparison of the effects on clonorchiasis with albendazole candy and praziquantel, Chin J Parasitol Parasitic Dis, 17, 376
- ZD Qiu, 1985, Praziquantel in the treatment of 248 cases of clonorchiasis, Chin J Clin Hepatol, 1, 47
- Q Lan, 2008, Effect observation on 16 patients with hookworm infection treated with praziquantel, Parasit Dis and Infect Dis, 6, 223
Cited by
Sorted by citations
Qian, M., Utzinger, J., Keiser, J., & Zhou, X. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60313-0 · Cited by 321
Self-citationAlbendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286
Tang, Z., Huang, Y., & Yu, X. (2016) · Infectious Diseases of Poverty · doi:10.1186/s40249-016-0166-1 · Cited by 186
A brief review on the mode of action of antinematodal drugs
Abongwa, M., Martin, R. J., & Robertson, A. P. (2017) · Acta veterinaria · doi:10.1515/acve-2017-0013 · Cited by 160
Liver Fluke-Associated Biliary Tract Cancer
Prueksapanich, P., Piyachaturawat, P., Aumpansub, P., Ridtitid, W., Chaiteerakij, R., & Rerknimitr, R. (2018) · Gut and Liver · doi:10.5009/gnl17102 · Cited by 118
Metadata
- Authors
- Xu, L.-L., Jiang, B., Duan, J.-H., Zhuang, S.-F., Liu, Y.-C., Zhu, S.-Q., Zhang, L.-P., Zhang, H.-B., Xiao, S.-H., & Zhou, X.-N.
- Affiliations
- National Institute for Parasitic Diseases (CN)
- Hunan Provincial Center for Disease Control and Prevention (CN)
- Corresponding author
- Zhou, Xiao-Nong
- Venue
- PLoS Neglected Tropical Diseases
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-08-14
- Volume
- 8
- Issue
- 8
- Pages
- e3046
- ISSN
- 1935-2727 (ISSN-L)
- 1935-2735
- PMC
- PMC4133228
- OpenAlex
- W2089764328
- Cited by
- 41
- References
- 39
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 1
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS neglected tropical diseases (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Greater South Information System
- Funders
- Centers for Disease Control and Prevention
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Life Sciences › Immunology and Microbiology › Parasitology › Helminth infection and control
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Keywords
- Clonorchis sinensis, praziquantel, tribendimidine, mebendazole, helminth co-infection, intestinal nematodes, hookworm, Ascaris lumbricoides, Trichuris trichiura, cure rate, egg reduction rate, drug safety, anthelmintic efficacy, single-dose therapy, retreatment
- MeSH terms
- Adult, Animals, Anthelmintics, Ascariasis, Clonorchiasis, Female, Helminthiasis, Humans, Male, Mebendazole, Middle Aged, Phenylenediamines, Praziquantel, Coinfection
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