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Cited by 1,339

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine

Open access
Sonoyama, Wataru, Liu, Yi, Fang, Dianji, Yamaza, Takayoshi, Seo, Byoung-Moo, Zhang, Chunmei, Liu, He, Gronthos, Stan, Wang, Cun-Yu, Shi, Songtao, Wang, Songlin·2006·PLoS ONE

Abstract

Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance.

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Crossref · 10.1371/journal.pone.0000079

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Metadata

Authors
Sonoyama, W., Liu, Y., Fang, D., Yamaza, T., Seo, B.-M., Zhang, C., Liu, H., Gronthos, S., Wang, C.-Y., Shi, S., & Wang, S.
Venue
PLoS ONE
Published
2006-12-20
Volume
1
Issue
1
Pages
e79
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2148562877
Cited by
1,339
References
1
FWCI
26.93
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine. https://app.cochat.ai/papers/10.1371/journal.pone.0000079
The paper
Sonoyama, W., Liu, Y., Fang, D., Yamaza, T., Seo, B.-M., Zhang, C., Liu, H., Gronthos, S., Wang, C.-Y., Shi, S., & Wang, S. (2006). Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine. PLoS ONE. https://doi.org/10.1371/journal.pone.0000079

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