Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 281

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Changes in the Treatment Responses to Artesunate-Mefloquine on the Northwestern Border of Thailand during 13 Years of Continuous Deployment

Open access
Carrara, Verena Ilona, Zwang, Julien, Ashley, Elizabeth A., Price, Ric N., Stepniewska, Kasia, Barends, Marion, Brockman, Alan, Anderson, Tim, McGready, Rose, Phaiphun, Lucy, Proux, Stephane, van Vugt, Michele, Hutagalung, Robert, Lwin, Khin Maung, Phyo, Aung Pyae, Preechapornkul, Piyanuch, Imwong, Mallika, Pukrittayakamee, Sasithon, Singhasivanon, Pratap, White, Nicholas J., Nosten, François·2009·PLoS ONE
DOI 10.1371/journal.pone.0004551
Open this paper in CoChat — free account

Abstract

BACKGROUND: Artemisinin combination treatments (ACT) are recommended as first line treatment for falciparum malaria throughout the malaria affected world. We reviewed the efficacy of a 3-day regimen of mefloquine and artesunate regimen (MAS(3)), over a 13 year period of continuous deployment as first-line treatment in camps for displaced persons and in clinics for migrant population along the Thai-Myanmar border. METHODS AND FINDINGS: 3,264 patients were enrolled in prospective treatment trials between 1995 and 2007 and treated with MAS(3). The proportion of patients with parasitaemia persisting on day-2 increased significantly from 4.5% before 2001 to 21.9% since 2002 (p<0.001). Delayed parasite clearance was associated with increased risk of developing gametocytaemia (AOR = 2.29; 95% CI, 2.00-2.69, p = 0.002). Gametocytaemia on admission and carriage also increased over the years (p = 0.001, test for trend, for both). MAS(3) efficacy has declined slightly but significantly (Hazards ratio 1.13; 95% CI, 1.07-1.19, p<0.001), although efficacy in 2007 remained well within acceptable limits: 96.5% (95% CI, 91.0-98.7). The in vitro susceptibility of P. falciparum to artesunate increased significantly until 2002, but thereafter declined to levels close to those of 13 years ago (geometric mean in 2007: 4.2 nM/l; 95% CI, 3.2-5.5). The proportion of infections caused by parasites with increased pfmdr1 copy number rose from 30% (12/40) in 1996 to 53% (24/45) in 2006 (p = 0.012, test for trend). CONCLUSION: Artesunate-mefloquine remains a highly efficacious antimalarial treatment in this area despite 13 years of widespread intense deployment, but there is evidence of a modest increase in resistance. Of particular concern is the slowing of parasitological response to artesunate and the associated increase in gametocyte carriage.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0004551

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 33 references

Cited by

See all 281

Metadata

Authors
Carrara, V. I., Zwang, J., Ashley, E. A., Price, R. N., Stepniewska, K., Barends, M., Brockman, A., Anderson, T., McGready, R., Phaiphun, L., Proux, S., van Vugt, M., Hutagalung, R., Lwin, K. M., Phyo, A. P., Preechapornkul, P., Imwong, M., Pukrittayakamee, S., Singhasivanon, P., White, N. J., & Nosten, F.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2009-02-23
Volume
4
Issue
2
Pages
e4551
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0004551
OpenAlex
W2010357659
Cited by
281
References
33
FWCI
36.44
Type
journal article
Language
en
Open access
gold

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Changes in the Treatment Responses to Artesunate-Mefloquine on the Northwestern Border of Thailand during 13 Years of Continuous Deployment. https://app.cochat.ai/papers/10.1371/journal.pone.0004551
The paper
Carrara, V. I., Zwang, J., Ashley, E. A., Price, R. N., Stepniewska, K., Barends, M., Brockman, A., Anderson, T., McGready, R., Phaiphun, L., Proux, S., van Vugt, M., Hutagalung, R., Lwin, K. M., Phyo, A. P., Preechapornkul, P., Imwong, M., Pukrittayakamee, S., Singhasivanon, P., . . . Nosten, F. (2009). Changes in the Treatment Responses to Artesunate-Mefloquine on the Northwestern Border of Thailand during 13 Years of Continuous Deployment. PLoS ONE. https://doi.org/10.1371/journal.pone.0004551

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.