The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1
Open accessAbstract
We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.
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Classical genetic analysis has indicated linkage disequilibrium between polymorphisms around the HERV-Fc1 locus and MS.
“Indeed, classical genetic analysis has indicated linkage disequilibrium between polymorphisms around the HERV-Fc1 locus and MS 89.”
From Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis (2013) · cites this paper as [89]
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Tristem, M. (2000) · Journal of Virology · doi:10.1128/jvi.74.8.3715-3730.2000 · Cited by 330 · cited 1× · see citing works
“genes have shown that HERV-Fc is closely related to HERV-H, more distantly related to HERV-W and only remotely related to HERV-K”
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Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis
Young, G. R., Stoye, J. P., & Kassiotis, G. (2013) · BioEssays · doi:10.1002/bies.201300049 · Cited by 78 · see citing works
“Indeed, classical genetic analysis has indicated linkage disequilibrium between polymorphisms around the HERVFc1 locus and MS [89].”
BackgroundRepetitive elements in aging and neurodegeneration
Copley, K. E., & Shorter, J. (2023) · Trends in Genetics · doi:10.1016/j.tig.2023.02.008 · Cited by 70 · see citing works
- Authors
- Nexø, B. A., Christensen, T., Frederiksen, J., Møller-Larsen, A., Oturai, A. B., Villesen, P., Hansen, B., Nissen, K. K., Laska, M. J., Petersen, T. S., Bonnesen, S., Hedemand, A., Wu, T., Wang, X., Zhang, X., Brudek, T., Maric, R., Søndergaard, H. B., Sellebjerg, F., Brusgaard, K., Kjeldbjerg, A. L., Rasmussen, H. B., Nielsen, A. L., Nyegaard, M., Petersen, T., Børglum, A. D., & Pedersen, F. S.
- Affiliations
- Aarhus University (DK)
- Glostrup Hospital (DK)
- Copenhagen University Hospital (DK)
- BGI Group (China) (CN)
- Odense University Hospital (DK)
- Sankt Hans Hospital (DK)
- Corresponding author
- Nexø, Bjørn A.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-02-02
- Volume
- 6
- Issue
- 2
- Pages
- e16652
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3032779
- OpenAlex
- W2065265074
- Cited by
- 83
- References
- 1
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 7 · 2014: 5 · 2013: 12 · 2012: 5
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Johns Hopkins University
- Scleroseforeningen
- Multiple Sclerosis Society
- Lundbeckfonden
- Warwara Larsens Fond
- H. Lundbeck A/S
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- multiple sclerosis, etiology, human endogenous retroviruses, TRIM5, single nucleotide polymorphisms, genetic association, disease susceptibility
- MeSH terms
- Alleles, DNA, Viral, Female, Heterozygote, Humans, Male, Multiple Sclerosis, Cohort Studies, Linkage Disequilibrium, Odds Ratio, Case-Control Studies, Genetic Predisposition to Disease, Endogenous Retroviruses, Polymorphism, Single Nucleotide
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