Cited by 262HIV-related health complications and treatmentsBone health and osteoporosis researchHIV/AIDS Research and Interventions

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Increased Risk of Fragility Fractures among HIV Infected Compared to Uninfected Male Veterans

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Womack, Julie A., Goulet, Joseph L., Gibert, Cynthia, Brandt, Cynthia, Chang, Chung Chou, Gulanski, Barbara, Fraenkel, Liana, Mattocks, Kristin, Rimland, David, Rodriguez-Barradas, Maria C., Tate, Janet, Yin, Michael T., Justice, Amy C., for the Veterans Aging Cohort Study Project Team·2011·PLoS ONE

DOI 10.1371/journal.pone.0017217PMC PMC3040233

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Abstract

BACKGROUND: HIV infection has been associated with an increased risk of fragility fracture. We explored whether or not this increased risk persisted in HIV infected and uninfected men when controlling for traditional fragility fracture risk factors. METHODOLOGY/PRINCIPAL FINDINGS: Cox regression models were used to assess the association of HIV infection with the risk for incident hip, vertebral, or upper arm fracture in male Veterans enrolled in the Veterans Aging Cohort Study Virtual Cohort (VACS-VC). We calculated adjusted hazard ratios comparing HIV status and controlling for demographics and other established risk factors. The sample consisted of 119,318 men, 33% of whom were HIV infected (34% aged 50 years or older at baseline, and 55% black or Hispanic). Median body mass index (BMI) was lower in HIV infected compared with uninfected men (25 vs. 28 kg/m²; p<0.0001). Unadjusted risk for fracture was higher among HIV infected compared with uninfected men [HR: 1.32 (95% CI: 1.20, 1.47)]. After adjusting for demographics, comorbid disease, smoking and alcohol abuse, HIV infection remained associated with an increased fracture risk [HR: 1.24 (95% CI: 1.11, 1.39)]. However, adjusting for BMI attenuated this association [HR: 1.10 (95% CI: 0.97, 1.25)]. The only HIV-specific factor associated with fragility fracture was current protease inhibitor use [HR: 1.41 (95% CI: 1.16, 1.70)]. CONCLUSIONS/SIGNIFICANCE: HIV infection is associated with fragility fracture risk. This risk is attenuated by BMI.

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Landis, J. R., & Koch, G. G. (1977) · Biometrics · doi:10.2307/2529310 · Cited by 81,148
Inference and missing data
RUBIN, D. B. (1976) · Biometrika · doi:10.1093/biomet/63.3.581 · Cited by 9,925
Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls
Sterne, J. A. C., White, I. R., Carlin, J. B., Spratt, M., Royston, P., Kenward, M. G., Wood, A. M., & Carpenter, J. R. (2009) · BMJ · doi:10.1136/bmj.b2393 · Cited by 7,299
FRAX™ and the assessment of fracture probability in men and women from the UK
Kanis, J. A., Johnell, O., Oden, A., Johansson, H., & McCloskey, E. (2008) · Osteoporosis International · doi:10.1007/s00198-007-0543-5 · Cited by 2,467
Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies.
(2008) · The Lancet · doi:10.1016/s0140-6736(08)61113-7 · Cited by 1,661
Body mass index as a predictor of fracture risk: A meta-analysis
De Laet, C., Kanis, J. A., Odén, A., Johanson, H., Johnell, O., Delmas, P., Eisman, J. A., Kroger, H., Fujiwara, S., Garnero, P., et al. (2005) · Osteoporosis International · doi:10.1007/s00198-005-1863-y · Cited by 1,622
Use of Inhaled Corticosteroids and Risk of Fractures
van Staa, T. P., Leufkens, H. G. M., & Cooper, C. C. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.3.581 · Cited by 1,297
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Van Staa, T. P., Leufkens, H. G. M., Abenhaim, L., Zhang, B., & Cooper, C. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.6.993 · Cited by 1,263
Liver-Related Deaths in Persons Infected With the Human Immunodeficiency Virus
The Data Collection on Adverse Events of Anti-HIV Drugs Study Group* (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.15.1632 · Cited by 1,115
Bone Mineral Density Thresholds for Pharmacological Intervention to Prevent Fractures
Siris, E. S., Chen, Y.-T., Abbott, T. A., Barrett-Connor, E. L., Miller, P. D., Wehren, L. E., & Berger, M. L. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.10.1108 · Cited by 1,109

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Horvath, S., & Levine, A. J. (2015) · Journal of Infectious Diseases · doi:10.1093/infdis/jiv277 · Cited by 556
HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group
High, K. P., Brennan-Ing, M., Clifford, D. B., Cohen, M. H., Currier, J., Deeks, S. G., Deren, S., Effros, R. B., Gebo, K., Goronzy, J. J., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31825a3668 · Cited by 522
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Bedimo, R., Maalouf, N. M., Zhang, S., Drechsler, H., & Tebas, P. (2012) · AIDS · doi:10.1097/qad.0b013e32835192ae · Cited by 324
The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis
Weitzmann, M. N. (2013) · Scientifica · doi:10.1155/2013/125705 · Cited by 264
Physiological and pathophysiological bone turnover — role of the immune system
Weitzmann, M. N., & Ofotokun, I. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.91 · Cited by 247
The Next Therapeutic Challenge in HIV: Polypharmacy
Edelman, E. J., Gordon, K. S., Glover, J. G., McNicholl, I. R., Fiellin, D. A., & Justice, A. C. (2013) · Drugs & Aging · doi:10.1007/s40266-013-0093-9 · Cited by 232
Self-citation
Comorbidities Among US Patients With Prevalent HIV Infection—A Trend Analysis
Gallant, J. E., Hsue, P. Y., Shreay, S., & Meyer, N. M. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix518 · Cited by 220
Predictive Accuracy of the Veterans Aging Cohort Study Index for Mortality With HIV Infection
Justice, A. C., Modur, S. P., Tate, J. P., Althoff, K. N., Jacobson, L. P., Gebo, K. A., Kitahata, M. M., Horberg, M. A., Brooks, J. T., Buchacz, K. A., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31827df36c · Cited by 222
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HIV Infection and Older Americans: The Public Health Perspective
Brooks, J. T., Buchacz, K. A., Gebo, K. A., & Mermin, J. (2012) · American Journal of Public Health · doi:10.2105/ajph.2012.300844 · Cited by 204
Bone and the Immune System
Weitzmann, M. N. (2017) · Toxicologic Pathology · doi:10.1177/0192623317735316 · Cited by 188
Functional Impairment, Disability, and Frailty in Adults Aging with HIV-Infection
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Hansen, A. E., Gerstoft, J., Kronborg, G., Larsen, C. S., Pedersen, C., Pedersen, G., & Obel, N. (2011) · AIDS · doi:10.1097/qad.0b013e32834ed8a7 · Cited by 147
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Shiau, S., Broun, E. C., Arpadi, S. M., & Yin, M. T. (2013) · AIDS · doi:10.1097/qad.0b013e328361d241 · Cited by 147
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Titanji, K., Vunnava, A., Sheth, A. N., Lahiri, C. D., Lennox, J. L., Sanford, S. E., Foster, A., Knežević, A., Easley, K. A., Weitzmann, M. N., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004497 · Cited by 133
British HIV Association guidelines for the treatment of HIV ‐1‐positive adults with antiretroviral therapy 2015
Churchill, D. R., Waters, L. J., Ahmed, N., Angus, B., Boffito, M., Bower, M., Dunn, D. T., Edwards, S., Emerson, C., Fidler, S. J., et al. (2016) · HIV Medicine · doi:10.1111/hiv.12426 · Cited by 133
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Overton, E. T., Chan, E. S., Brown, T. T., Tebas, P., McComsey, G. A., Melbourne, K. M., Napoli, A., Hardin, W. R., Ribaudo, H. J., & Yin, M. T. (2015) · Annals of Internal Medicine · doi:10.7326/m14-1409 · Cited by 122
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Edelman, E. J., Gordon, K. S., Becker, W. C., Goulet, J. L., Skanderson, M., Gaither, J. R., Braden, J. B., Gordon, A. J., Kerns, R. D., Justice, A. C., et al. (2012) · Journal of General Internal Medicine · doi:10.1007/s11606-012-2189-z · Cited by 112
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Levine, A. J., Quach, A., Moore, D. J., Achim, C. L., Soontornniyomkij, V., Masliah, E., Singer, E. J., Gelman, B. B., Nemanim, N. M., & Horvath, S. (2015) · Journal of NeuroVirology · doi:10.1007/s13365-015-0406-3 · Cited by 114
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Risk Factors for Hospitalization and Medical Intensive Care Unit (MICU) Admission Among HIV-Infected Veterans
Akgün, K. M., Gordon, K. S., Pisani, M. A., Fried, T. R., McGinnis, K. A., Tate, J. P., Butt, A. A., Gibert, C. L., Huang, L., Rodriguez‐Barradas, M. C., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e318278f3fa · Cited by 105
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HIV: Inflammation and Bone
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Antiretroviral Therapy Induces a Rapid Increase in Bone Resorption that is Positively Associated with the Magnitude of Immune Reconstitution in HIV Infection
Ofotokun, I., Titanji, K., Vunnava, A., Roser-Page, S., Vikulina, T., Villinger, F., Rogers, K., Sheth, A., Lahiri, C. D., Lennox, J., et al. (2016) · AIDS (London) · doi:10.1097/qad.0000000000000918 · Cited by 94
An Adapted Frailty-Related Phenotype and the VACS Index as Predictors of Hospitalization and Mortality in HIV-Infected and Uninfected Individuals
Akgün, K. M., Tate, J. P., Crothers, K. A., Crystal, S., Leaf, D. A., Womack, J. A., Brown, T. T., Justice, A. C., & Oursler, K. K. (2014) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000341 · Cited by 91
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Sharma, A., Shi, Q., Hoover, D. R., Anastos, K., Tien, P. C., Young, M., Cohen, M. H., Golub, E. T., Gustafson, D., & Yin, M. T. (2015) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000674 · Cited by 88
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Self-citation
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HIV infection and bone disease
Compston, J. E. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12520 · Cited by 77
Fractures after antiretroviral initiation
Yin, M. T., Kendall, M. A., Wu, X., Tassiopoulos, K., Hochberg, M. C., Huang, J. S., Glesby, M. J., Bolívar, H., & McComsey, G. A. (2012) · AIDS · doi:10.1097/qad.0b013e328359a8ca · Cited by 78
Self-citation
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Moore, R. C., Moore, D. J., Thompson, W. K., Vahia, I. V., Grant, I., & Jeste, D. V. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12m08100 · Cited by 76
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Kooij, K. W., Wit, F. W. N. M., Bisschop, P. H. L. T., Schouten, J., Stolte, I. G., Prins, M., van der Valk, M., Prins, J. M., van Eck‐Smit, B. L. F., Lips, P. T. A. M., et al. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu499 · Cited by 64
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Childs, K. E., Welz, T., Samarawickrama, A., & Post, F. A. (2011) · AIDS · doi:10.1097/qad.0b013e32834f324b · Cited by 62
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Moyle, G. J., Stellbrink, H., Compston, J. E., Orkin, C. M., Arribas, J. R., Domingo, P., Granier, C., Pearce, H., Sedani, S., Gartland, M., et al. (2013) · Antiviral Therapy · doi:10.3851/imp2667 · Cited by 61
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Titanji, K. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01851 · Cited by 61
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Erlandson, K. M., Allshouse, A. A., Jankowski, C. M., MaWhinney, S., Kohrt, W. M., & Campbell, T. (2014) · AIDS · doi:10.1097/qad.0000000000000384 · Cited by 61
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Torti, C., Mazziotti, G., Soldini, P., Focà, E., Maroldi, R., Gotti, D., Carosi, G., & Giustina, A. (2011) · Endocrine · doi:10.1007/s12020-011-9586-7 · Cited by 60
The role of HIV and antiretroviral therapy in bone disease.
Gutiérrez, F., & Masiá, M. (2011) · PubMed · Cited by 55
Fracture Prediction With Modified-FRAX in Older HIV-Infected and Uninfected Men
Yin, M. T., Shiau, S., Rimland, D., Gibert, C. L., Bedimo, R., Rodriguez‐Barradas, M. C., Harwood, K., Aschheim, J., Justice, A. C., & Womack, J. A. (2016) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000998 · Cited by 55
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Moran, C. A., Weitzmann, M. N., & Ofotokun, I. (2017) · Current treatment options in infectious diseases/Current treatment options in infectious disease · doi:10.1007/s40506-017-0109-9 · Cited by 53
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Chang, C., Chan, Y.-L., Pramukti, I., Ko, N., & Tai, T. (2021) · Archives of Osteoporosis · doi:10.1007/s11657-021-00903-y · Cited by 55
Self-citation
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Leontiadis, G. I., & Moayyedi, P. (2014) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-014-0030-y · Cited by 52
The protease inhibitors and HIV-associated bone loss
Moran, C. A., Weitzmann, M. N., & Ofotokun, I. (2016) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000260 · Cited by 52
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Premaor, M. O., & Compston, J. E. (2018) · JBMR Plus · doi:10.1002/jbm4.10055 · Cited by 52
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Powderly, W. G. (2012) · Current HIV/AIDS Reports · doi:10.1007/s11904-012-0119-7 · Cited by 51
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Brown, T. T., Chen, Y., Currier, J. S., Ribaudo, H. J., Rothenberg, J., Dubé, M. P., Murphy, R. L., Stein, J. H., & McComsey, G. A. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e318295eb1d · Cited by 49
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Justice, A. C., & Braithwaite, R. S. (2012) · AIDS · doi:10.1097/qad.0b013e3283558500 · Cited by 48
Self-citation
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Cotter, A. G., & Mallon, P. W. G. (2013) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000028 · Cited by 48
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Mulligan, K. M., Harris, D. R., Emmanuel, P. J., Fielding, R. A., Worrell, C., Kapogiannis, B. G., Monte, D., Sleasman, J. W., Wilson, C. M., Aldrovandi, G. M., et al. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis455 · Cited by 48
Self-citation
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Loutfy, M. R., Andany, N., Kennedy, V. L., & Aden, M. (2016) · International Journal of Women s Health · doi:10.2147/ijwh.s62615 · Cited by 47
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Maalouf, N. M., Zhang, S., Drechsler, H., Brown, G., Tebas, P., & Bedimo, R. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1988 · Cited by 46
Effect of Alendronate on HIV-Associated Osteoporosis: A Randomized, Double-Blind, Placebo-Controlled, 96-Week Trial (ANRS 120)
Rozenberg, S., Lanoy, É., Bentata, M., Viard, J., Valantin, M., Missy, P., Darasteanu, I., Roux, C., Kolta, S., & Costagliola, D. G. (2012) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2011.0224 · Cited by 45
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Focà, E., Motta, D., Borderi, M., Gotti, D., Albini, L., Calabresi, A., Izzo, I., Bellagamba, R., Narciso, P., Sighinolfi, L., et al. (2012) · BMC Infectious Diseases · doi:10.1186/1471-2334-12-38 · Cited by 41
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Self-citation
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Güerri‐Fernández, R., Molina‐Morant, D., Villar-García, J., Prieto‐Alhambra, D., Mellibovsky, L., Nogués, X., González‐Mena, A., Guelar, A., Trenchs‐Rodríguez, M., Herrera, S., et al. (2016) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000965 · Cited by 39
Studying the neuropsychological sequelae of SARS-CoV-2: lessons learned from 35 years of neuroHIV research
Levine, A. J., Sacktor, N. C., & Becker, J. T. (2020) · Journal of NeuroVirology · doi:10.1007/s13365-020-00897-2 · Cited by 39
Overall benefit of antiretroviral treatment on the risk of fracture in HIV
Mundy, L. M., Youk, A. O., McComsey, G. A., & Bowlin, S. J. (2012) · AIDS · doi:10.1097/qad.0b013e328351997f · Cited by 38
HIV infection and osteoporosis
Compston, J. E. (2015) · BoneKEy Reports · doi:10.1038/bonekey.2015.3 · Cited by 38
Classification of radiology reports for falls in an HIV study cohort
Bates, J., Fodeh, S. J., Brandt, C., & Womack, J. A. (2015) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocv155 · Cited by 36
Self-citation
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Peters, B., Post, F. A., Wierzbicki, A. S., Phillips, A. N., Power, L., Das, S., Johnson, M. A., Moyle, G. J., Hughes, L., Wilkins, E., et al. (2012) · HIV Medicine · doi:10.1111/j.1468-1293.2012.01055.x · Cited by 37
Bone Health and Human Immunodeficiency Virus Infection
Schafer, J. J., Manlangit, K., & Squires, K. (2013) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1257 · Cited by 37
HIV, pathology and epigenetic age acceleration in different human tissues
Horvath, S., Lin, D. T. S., Kobor, M. S., Zoller, J. A., SAID, J. W., Morgello, S., Singer, E. J., Yong, W. H., Jamieson, B. D., & Levine, A. J. (2022) · GeroScience · doi:10.1007/s11357-022-00560-0 · Cited by 38
Peak Bone Mass in Young HIV-Infected Patients Compared With Healthy Controls
Negredo, E., Domingo, P., Ferrer, E., Estrada, V., Curran, A., Navarro, A., Isernia, V., Rosales, J., Pérez‐Álvarez, N., Puig, J., et al. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000435598.20104.d6 · Cited by 35
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Zhou, S., Martin, K. R., Corbett, A., Napravnik, S., Eron, J. J., Zhu, Y., Casciere, B., Boulton, C., Loy, B., Smith, S., et al. (2014) · AIDS Patient Care and STDs · doi:10.1089/apc.2014.0010 · Cited by 35
Prevalence of sub-clinical vertebral fractures in HIV-infected patients.
Borderi, M., Calza, L., Colangeli, Vanino, E., Viale, P., Gibellini, D., & Re, M. C. (2014) · PubMed · Cited by 35
Osteoporosis knowledge, self-efficacy, and health beliefs among Chinese individuals with HIV
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Arpadi, S. M. (2014) · Journal of AIDS & Clinical Research · doi:10.4172/2155-6113.1000374 · Cited by 34
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Tebas, P., Kumar, P. N., Hicks, C. B., Granier, C., Wynne, B., Min, S., & Pappa, K. A. (2015) · AIDS · doi:10.1097/qad.0000000000000863 · Cited by 33
HIV Infection and Osteoporosis: Pathophysiology, Diagnosis, and Treatment Options
Rothman, M. S., & Bessesen, M. T. (2012) · Current Osteoporosis Reports · doi:10.1007/s11914-012-0125-0 · Cited by 33
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Self-citation
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Compston, J. E. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2014.05.001 · Cited by 32
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Byrne, D. D., Newcomb, C. W., Carbonari, D. M., Nezamzadeh, M. S., Leidl, K. B. F., Herlim, M., Yang, Y.-X., Hennessy, S., Kostman, J. R., Leonard, M. B., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.04.001 · Cited by 31
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Mallon, P. W. G. (2014) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000080 · Cited by 31
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Hoy, J., & Young, B. (2016) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000249 · Cited by 29
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Short, C.-E. S., Shaw, S. G., Fisher, M., Walker-Bone, K. E., & Gilleece, Y. C. (2013) · International Journal of STD & AIDS · doi:10.1177/0956462413492714 · Cited by 29
Hyperparathyroidism and Complications Associated with Vitamin D Deficiency in HIV-Infected Adults in New York City, New York
Kwan, C. K., Eckhardt, B. J., Baghdadi, J. D., & Aberg, J. A. (2012) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2011.0325 · Cited by 29
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Re, V. L., Lynn, K., Stumm, E. R., Long, J., Nezamzadeh, M. S., Baker, J. F., Hoofnagle, A. N., Kapalko, A., Mounzer, K., Zemel, B. S., et al. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv147 · Cited by 28
Association of chronic obstructive pulmonary disease with frailty measurements in HIV-infected and uninfected Veterans
Akgün, K. M., Tate, J. P., Oursler, K. K., Crystal, S., Leaf, D. A., Womack, J. A., Brown, T. T., Justice, A. C., & Crothers, K. A. (2016) · AIDS · doi:10.1097/qad.0000000000001162 · Cited by 28
Self-citation
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Bedimo, R. G., Maalouf, N. M., & Re, V. L. (2016) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000259 · Cited by 27
Comparison between the gold standard DXA with calcaneal quantitative ultrasound based-strategy (QUS) to detect osteoporosis in an HIV infected cohort
Quirós-Roldán, E., Brianese, N., Raffetti, E., Focà, E., Pezzoli, M. C., Bonito, A., Ferraresi, A., Lanza, P., Porcelli, T., & Castelli, F. (2017) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2017.08.003 · Cited by 26
Reduced Quantitative Ultrasound Bone Mineral Density in HIV-Infected Patients on Antiretroviral Therapy in Senegal
Cournil, A., Eymard‐Duvernay, S., Diouf, A., Moquet, C., Coutherut, J., Gueye, N. F. N., Cames, C., Taverne, B., Bork, K., Sow, P. S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031726 · Cited by 26
Prevalence of Low Bone Mineral Density in Men and Women Infected With Human Immunodeficiency Virus 1 and a Proposal for Screening Strategy
Mary‐Krause, M., Viard, J., Ename-Mkoumazok, B., Bentata, M., Valantin, M., Missy, P., Darasteanu, I., Roux, C., Kolta, S., Costagliola, D. G., et al. (2012) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2012.04.001 · Cited by 26

Authors: Womack, J. A., Goulet, J. L., Gibert, C., Brandt, C., Chang, C. C., Gulanski, B., Fraenkel, L., Mattocks, K., Rimland, D., Rodriguez-Barradas, M. C., Tate, J., Yin, M. T., Justice, A. C., & for the Veterans Aging Cohort Study Project Team
Affiliations: VA Connecticut Healthcare System (US)
George Washington University (US)
Yale University (US)
University of Pittsburgh (US)
Emory University (US)
Columbia University Irving Medical Center (US)
Corresponding author: Womack, Julie A.
ORCID: Womack, Julie A.
Goulet, Joseph L.
Brandt, Cynthia
Gulanski, Barbara
Fraenkel, Liana
Mattocks, Kristin
Yin, Michael T.
Justice, Amy C.
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2011-02-16
Volume: 6
Issue: 2
Pages: e17217
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0017217
PMC: PMC3040233
OpenAlex: W2155638837
Cited by: 261
References: 60
Citations by year: 2026: 3 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 16 · 2020: 16 · 2019: 8 · 2018: 18 · 2017: 17 · 2016: 23 · 2015: 25 · 2014: 32 · 2013: 31 · 2012: 31
FWCI: 39.95
Type: journal article
Language: en
Open access: gold
doi.org
Licence: public-domain
creativecommons.org/publicdomain/zero/1.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, public-domain)
PubMed Central (publishedVersion, public-domain)
PubMed (publishedVersion)
D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion, public-domain)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: U.S. Department of Veterans Affairs
National Institute on Alcohol Abuse and Alcoholism (U10AA013566, U10- AA13566)
National Institute of Nursing Research (K01NR013437)
National Institute of Allergy and Infectious Diseases (K23AI059884)
Topics: Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords: HIV infection, fragility fractures, hip fracture, vertebral fractures, upper arm fractures, male veterans, body mass index, protease inhibitors, fracture risk factors, aging
MeSH terms: Aged, Aged, 80 and over, Follow-Up Studies, Humans, Male, Middle Aged, Osteoporosis, Risk Factors, Sex Characteristics, Veterans, HIV-1, Bone Density, HIV Infections, Fractures, Bone

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Increased Risk of Fragility Fractures among HIV Infected Compared to Uninfected Male Veterans

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