CoChat
Sign Up
Cited by 200

The DOI matches its Crossref record.

Effect of Hookworm Infection on Wheat Challenge in Celiac Disease – A Randomised Double-Blinded Placebo Controlled Trial

Daveson, A. James, Jones, Dianne M., Gaze, Soraya, McSorley, Henry, Clouston, Andrew, Pascoe, Andrew, Cooke, Sharon, Speare, Richard, Macdonald, Graeme A., Anderson, Robert, McCarthy, James S., Loukas, Alex, Croese, John·2011·PLoS ONE
DOI 10.1371/journal.pone.0017366PMC PMC3050888
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0017366

Cites

Statistics

Figures

Figure 1 CONSORT flowchart.
Figure 1 CONSORT flowchart.CC BY · PubMed Central
Figure 2 Recruitment and Protocol. Recruitment and summation of those excluded post screening (A), and trial outline (B).
Figure 2 Recruitment and Protocol. Recruitment and summation of those excluded post screening (A), and trial outline (B).CC BY · PubMed Central
Figure 3 Representative photographs of parasitic infection (A) Adult hookworm (B) Inoculation site.
Figure 3 Representative photographs of parasitic infection (A) Adult hookworm (B) Inoculation site.CC BY · PubMed Central
Figure 4 Symptom responses to hookworm infection. Control group is indicated by black circles, hookworm group by grey squares, values are mean +/− SEM. (A) pain events, (B) bowel motions/day, (C) flatulence, (D) skin rash, (E) lethargy, (F) wellbeing. Area under the curve analysis followed by Mann-Whitney U test to compare between groups showed that pain events (A) was significantly different between the groups.
Figure 4 Symptom responses to hookworm infection. Control group is indicated by black circles, hookworm group by grey squares, values are mean +/− SEM. (A) pain events, (B) bowel motions/day, (C) flatulence, (D) skin rash, (E) lethargy, (F) wellbeing. Area under the curve analysis followed by Mann-Whitney U test to compare between groups showed that pain events (A) was significantly different between the groups.CC BY · PubMed Central
Figure 5 Blood cell and marker levels. (A) white cell, (B) eosinophil (C) hemoglobin. Control group is indicated by black circles, hookworm group by grey squares, values are mean +/− SEM. Data was analyzed by two-way ANOVA: significant effects of time and interaction was shown in (B), and post-hoc one-way ANOVA on each group showed the differences between timepoints as indicated.
Figure 5 Blood cell and marker levels. (A) white cell, (B) eosinophil (C) hemoglobin. Control group is indicated by black circles, hookworm group by grey squares, values are mean +/− SEM. Data was analyzed by two-way ANOVA: significant effects of time and interaction was shown in (B), and post-hoc one-way ANOVA on each group showed the differences between timepoints as indicated.CC BY · PubMed Central
Figure 6 Histological and immunological results. (A) Marsh score and (B) IFN-γ ELISpot. Data was analyzed by two-way ANOVA: significant effects of time only were shown as indicated, no significant effect of group or interaction was found in (A) or (B).
Figure 6 Histological and immunological results. (A) Marsh score and (B) IFN-γ ELISpot. Data was analyzed by two-way ANOVA: significant effects of time only were shown as indicated, no significant effect of group or interaction was found in (A) or (B).CC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 34

  1. JF Bach, 2002, The effect of infections on susceptibility to autoimmune and allergic diseases., The N Engl J Med, 347, 911, 10.1056/NEJMra020100 · DOI
  2. JV Weinstock, 2009, Helminths and the IBD hygiene hypothesis., Inflamm Bowel Dis, 15, 128, 10.1002/ibd.20633 · DOI
  3. DM Altmann, 2009, Review series on helminths, immune modulation and the hygiene hypothesis: nematode coevolution with adaptive immunity, regulatory networks and the growth of inflammatory diseases., Immunology, 126, 1, 10.1111/j.1365-2567.2008.03006.x · DOI
  4. JA Jackson, 2009, Review series on helminths, immune modulation and the hygiene hypothesis: immunity against helminths and immunological phenomena in modern human populations: coevolutionary legacies?, Immunology, 126, 18, 10.1111/j.1365-2567.2008.03010.x · DOI
  5. M Fumagalli, 2009, Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions., J Exp Med, 206, 1395, 10.1084/jem.20082779 · DOI
  6. H Aoyama, 2007, An inverse relationship between autoimmune liver diseases and Strongyloides stercoralis infection., Am J Trop Med Hyg, 76, 972, 10.4269/ajtmh.2007.76.972 · DOI
  7. J Correale, 2007, Association between parasite infection and immune responses in multiple sclerosis., Ann Neurol, 61, 97, 10.1002/ana.21067 · DOI
  8. DE Elliott, 2009, Helminthic therapy: using worms to treat immune-mediated disease., Adv Exp Med Biol, 666, 157, 10.1007/978-1-4419-1601-3_12 · DOI
  9. NE Ruyssers, 2010, Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice., World J Gastroenterol, 16, 703, 10.3748/wjg.v16.i6.703 · DOI
  10. P Musgrove, 2009, Turning neglected tropical diseases into forgotten maladies., Health Aff (Millwood), 28, 1691, 10.1377/hlthaff.28.6.1691 · DOI
  11. J Feary, 2009, Safety of hookworm infection in individuals with measurable airway responsiveness: a randomized placebo-controlled feasibility study., Clin Exp Allergy, 39, 1060, 10.1111/j.1365-2222.2009.03187.x · DOI
  12. P Bager, 2010, Trichuris suis ova therapy for allergic rhinitis: a randomized, double-blind, placebo-controlled clinical trial., J Allergy Clin Immunol, 125, 123, 10.1016/j.jaci.2009.08.006 · DOI
  13. RW Summers, 2003, Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease., Am J Gastroenterol, 98, 2034, 10.1111/j.1572-0241.2003.07660.x · DOI
  14. RW Summers, 2005, Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial., Gastroenterology, 128, 825, 10.1053/j.gastro.2005.01.005 · DOI · Paper page
  15. PJ Hotez, 2004, Hookworm infection., N Engl J Med, 351, 799, 10.1056/NEJMra032492 · DOI
  16. C Maxwell, 1987, The clinical and immunologic responses of normal human volunteers to low dose hookworm (Necator americanus) infection., Am J Trop Med Hyg, 37, 126, 10.4269/ajtmh.1987.37.126 · DOI
  17. V Wright, 2005, Immune responses following experimental human hookworm infection., Clin Exp Immunol, 142, 398, 10.1111/j.1365-2249.2005.02945.x · DOI
  18. J Croese, 2006, Allergy controls the population density of Necator americanus in the small intestine., Gastroenterology, 131, 402, 10.1053/j.gastro.2006.05.019 · DOI
  19. K Mortimer, 2006, Dose-ranging study for trials of therapeutic infection with Necator americanus in humans., Am J Trop Med Hyg, 75, 914, 10.4269/ajtmh.2006.75.914 · DOI
  20. J Croese, 2006, A proof of concept study establishing Necator americanus in Crohn's patients and reservoir donors., Gut, 55, 136, 10.1136/gut.2005.079129 · DOI · Paper page
  21. RJ Quinnell, 2004, The immunoepidemiology of human hookworm infection., Parasite Immunol, 26, 443, 10.1111/j.0141-9838.2004.00727.x · DOI
  22. DA Leffler, 2009, A validated disease-specific symptom index for adults with celiac disease., Clin Gastroenterol Hepatol, 7, 1328, 10.1016/j.cgh.2009.07.031 · DOI
  23. PH Green, 2007, Celiac disease., N Engl J Med, 357, 1731, 10.1056/NEJMra071600 · DOI
  24. C Catassi, 2007, A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease., Am J Clin Nutr, 85, 160, 10.1093/ajcn/85.1.160 · DOI
  25. MN Marsh, 1995, Morphology of the mucosal lesion in gluten sensitivity., Baillieres Clin Gastroenterol, 9, 273, 10.1016/0950-3528(95)90032-2 · DOI
  26. J Tye-Din, 2008, Immunopathogenesis of celiac disease., Curr Gastroenterol Rep, 10, 458, 10.1007/s11894-008-0085-9 · DOI
  27. RP Anderson, 2000, In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope., Nat Med, 6, 337, 10.1038/73200 · DOI
  28. MF Kagnoff, 2007, Celiac disease: pathogenesis of a model immunogenetic disease., J Clin Invest, 117, 41, 10.1172/JCI30253 · DOI
  29. D Blount, 2009, Immunologic profiles of persons recruited for a randomized, placebo-controlled clinical trial of hookworm infection., Am J Trop Med Hyg, 81, 911, 10.4269/ajtmh.2009.09-0237 · DOI · Paper page
  30. ED Palmer, 1955, Course of egg output over a 15 year period in a case of experimentally induced necatoriasis americanus, in the absence of hyperinfection., Am J Trop Med Hyg, 4, 756, 10.4269/ajtmh.1955.4.756 · DOI
  31. PC Beaver, 1988, Light, long-lasting Necator infection in a volunteer., Am J Trop Med Hyg, 39, 369, 10.4269/ajtmh.1988.39.369 · DOI
  32. JR Feary, 2010, Experimental hookworm infection: a randomized placebo-controlled trial in asthma., Clin Exp Allergy, 40, 299, 10.1111/j.1365-2222.2009.03433.x · DOI · Paper page
  33. RW Summers, 2005, Trichuris suis therapy in Crohn's disease., Gut, 54, 87, 10.1136/gut.2004.041749 · DOI · Paper page
  34. J Glas, 2009, Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease., Am J Gastroenterol, 104, 1737, 10.1038/ajg.2009.163 · DOI

Cited by

Sorted by citations

Metadata

Authors
Daveson, A. J., Jones, D. M., Gaze, S., McSorley, H., Clouston, A., Pascoe, A., Cooke, S., Speare, R., Macdonald, G. A., Anderson, R., McCarthy, J. S., Loukas, A., & Croese, J.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2011-03-08
Volume
6
Issue
3
Pages
e17366
ISSN
1932-6203
DOI
10.1371/journal.pone.0017366
PMC
PMC3050888
Cited by
200
References
0
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review