2-Deoxy-D-Glucose Treatment Induces Ketogenesis, Sustains Mitochondrial Function, and Reduces Pathology in Female Mouse Model of Alzheimer's Disease

Yao, Jia, Chen, Shuhua, Mao, Zisu, Cadenas, Enrique, Brinton, Roberta Diaz·2011·PLoS ONE

Cited by (152)

Items 101–152 of 152

  1. Syntaxin 5 Overexpression andβ-Amyloid 1–42 Accumulation in Endoplasmic Reticulum of Hippocampal Cells in Rat Brain Induced by Ozone Exposure
    Luis Fernando Hernández-Zimbrón, Selva Rivas-Arancibia · 2016 · BioMed Research International
  2. Curcumae Radix Decreases Neurodegenerative Markers through Glycolysis Decrease and TCA Cycle Activation
    Seong-Lae Jo, Hyun Ju Yang, Jun H. Heo, Sang R. Lee, Hye Won Lee, Eui‐Ju Hong · 2022 · Nutrients
  3. Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons
    Divya Pathak, Amandine Berthet, Jacob Bendor, Katharine Yu, Rhyomi C. Sellnow, Adam L. Orr, Mai K. Nguyen, Robert H. Edwards, Fredric P. Manfredsson, Ken Nakamura · 2017 · eNeuro
  4. Golgi apparatus dis- and reorganizations studied with the aid of 2-deoxy-d-glucose and visualized by 3D-electron tomography
    Carmen Ranftler, Claudia Meißlitzer-Ruppitsch, Josef Neumüller, Adolf Ellinger, Margit Pavelka · 2016 · Histochemistry and Cell Biology
  5. Intermittent fasting and Alzheimer's disease—Targeting ketone bodies as a potential strategy for brain energy rescue
    YuanYuan Ye, Shi-Fan Chai, Xin-Ru Li, Meina Wu, Hong-Yan Cai, Zhao-Jun Wang · 2023 · Metabolic Brain Disease
  6. Effects of sex and APOE ε4 genotype on brain mitochondrial high-energy phosphates in midlife individuals at risk for Alzheimer’s disease: A 31Phosphorus MR spectroscopy study
    Steven Jett, J. Dyke, Camila Boneu Yepez, Camila Zarate, Caroline Carlton, Eva Schelbaum, Grace Jang, S. Pahlajani, S. Williams, Roberta Diaz Brinton et al. · 2023 · PLoS ONE
  7. Liraglutide Treatment Ameliorates Neurotoxicity Induced by Stable Silencing of Pin1
    Marzia Bianchi, Valentina Doria, Maria Rita Braghini, Stefania Petrini, Melania Manco · 2019 · International Journal of Molecular Sciences
  8. Pharmaceutical Intervention of Aging
    Minxian Qian, Baohua Liu · 2018 · Advances in experimental medicine and biology
  9. The impact of ketogenic diet on the onset and progression of multiple sclerosis
    Jurij D Brockhoff, S. Bereswill, M. Heimesaat · 2023 · European Journal of Microbiology & Immunology
  10. Alternate-day fasting improves cognitive and brain energy deficits by promoting ketone metabolism in the 3xTg mouse model of Alzheimer's disease
    Yucai Ye, Chaojing Fu, Zhiyong Li, Junli Sun, Xinru Li, Shi-Fan Chai, Shuo Li, Meng Hou, Hong-Yan Cai, Zhaojun Wang et al. · 2024 · Experimental Neurology
  11. The use of ketogenic diet in special situations: expanding use in intractable epilepsy and other neurologic disorders
    Munhyang Lee · 2012 · Korean Journal of Pediatrics
  12. Glucose enrichment impair neurotransmission and induce Aβ oligomerization that cannot be reversed by manipulating O-β-GlcNAcylation in the C. elegans model of Alzheimer's disease
    Waqar Ahmad · 2022 · The Journal of Nutritional Biochemistry
  13. Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative Stress
    Winston J. T. Tan, Joseph Santos‐Sacchi, Jane Marie Tonello, Anil Shanker, Alla V. Ivanova · 2023 · Antioxidants
  14. Neurophysiological correlates of subjective cognitive decline in perimenopausal and postmenopausal midlife women at risk for Alzheimer's disease
    Lisa Mosconi, Schantel Williams, Caroline Carlton, Caroline Andy, Francesca Fauci, Camila Zarate, Camila Boneu, Trisha Ajila, Matilde Nerattini, Steven Jett et al. · 2025 · Menopause The Journal of The North American Menopause Society
  15. iTRAQ-Based Proteomic Analysis of Dentate Gyrus in Temporal Lobe Epilepsy With Hippocampal Sclerosis
    Wenbiao Xiao, Zhiquan Yang, Xiao‐Xin Yan, Li Feng, Lili Long, Tian Tu, Na Deng, Wenjuan Chen, Bo Xiao, Hongyu Long et al. · 2021 · Frontiers in Neurology
  16. Markers of Alzheimer’s Disease in Primary Visual Cortex in Normal Aging in Mice
    Luis Fernando Hernández-Zimbrón, M Pérez-Hernández, Abigail Torres-Romero, Elisa Gorostieta-Salas, Roberto González-Salinas, Rosario Gulías-Cañizo, Hugo Quiroz–Mercado, Edgar Zenteno · 2017 · BioMed Research International
  17. Ketogenic Approaches for the Treatment of Alzheimer’s Disease
    Renata Gabuzyan, Christopher Lee, H. Nygaard · 2024 · Journal of Alzheimer's Disease
  18. Metabolic Management of Cancer
    Thomas N. Seyfried · 2012 · Wiley eBooks
  19. NLRP6 governs hippocampal microglial phagocytosis to resist stress-induced depressive-like behaviors in mice and the intervention effect of bezafibrate
    Fan Yang, Xiuqin Kong, Yuefeng Hu, Wanzhao Liu, Pengfei Xie, Yuexi Gu, Yan Zhang, Y.L. Yang, Chuanfeng Tang, Jianmei Li · 2025 · Journal of Advanced Research
  20. Potential Therapeutic Strategies to Prevent the Progression of Alzheimer to Disease States
    Ester Aso, Isidró Ferrer · 2013 · InTech eBooks
  21. Medium-chain triglycerides improve cognition and systemic metabolism in mouse models of Alzheimer’s disease
    Paule E. H. M’Bra, Laura K. Hamilton, Gaël Moquin‐Beaudry, Chenicka Lyn Mangahas, Federico Pratesi, Anne Castonguay, Sophia Mailloux, Manon Galoppin, Jessica Avila Lopez, Megan Bernier et al. · 2025 · Brain
  22. 2-Deoxyglucose protects hippocampal neurons against kainate-induced temporal lobe epilepsy by modulating monocyte-derived macrophages (mo-MΦ) and progranulin production in the hippocampus
    Farnaz Nikbakht, Rafie Belali, Homa Rasoolijazi, Ali Mohammadkhanizadeh · 2019 · Neuropeptides
  23. Nutritional/Metabolic Therapies in Animal Models of Amyotrophic Lateral Sclerosis, Alzheimer’s Disease, and Seizures
    Csilla Ari, Raffaele Pilla, Dominic P. D’Agostino · 2014 · Elsevier eBooks
  24. Effects of Ketogenic Diet on Increased Ethanol Consumption Induced by Social Stress in Female Mice
    Laura Torres-Rubio, Marina Daiana Reguilón, Susana Mellado, María Pascual, Marta Rodríguez‐Arias · 2024 · Nutrients
  25. A long-term ketogenic diet in young and aged rats has dissociable effects on prelimbic cortex and CA3 ensemble activity
    Abbi R. Hernandez, Maya E. Barrett, Katelyn N. Lubke, A. P. Maurer, S. Burke · 2023 · Frontiers in Aging Neuroscience
  26. Grape juice consumption and/or exercise training-induced neuroplasticity and memory improvement in healthy elderly women
    Viviane Rostirola Elsner, Lucieli Trevizol, Luisa Bassôa, Iasmin Borges Fraga, Inês Munhoz, Daniela Pochmann, Caroline Dani · 2018 · SDRP Journal of Cellular and Molecular Physiology
  27. Chronic Dietary Administration of 2-Deoxy-D-Glucose Does Not Compromise Neurobehavioral Functions at Tumor Preventive Doses in Mice
    Saurabh Pratap Singh, Mayank Kumar, Kailash Manda, Seenu Haridas, Anant Narayan Bhatt, Daman Saluja, Bilikere Srinivasa Rao Dwarakanath · 2015 · Journal of Behavioral and Brain Science
  28. Mitochondrial drug delivery systems
    W. Brad Hubbard, Hemendra J. Vekaria, Patrick G. Sullivan · 2020 · Elsevier eBooks
  29. Harnessing metabolic control for synaptic stability: REST/NRSF links glycolytic inhibition to excitatory neurotransmission
    Daniele Ferrante, Barbara Parisi, Antonella Marte, Dionisi Marianna, Cosimo Prestigio, Andrea Benzi, Santina Bruzzone, Fabio Benfenati, Franco Onofri, Pierluigi Valente et al. · 2025 · The Journal of Physiology
  30. Endogenous drivers of altered immune cell metabolism
    Lianne C. Shanley, Hannah K. Fitzgerald, Sinead A O’Rourke, Aisling Dunne · 2022 · Experimental Biology and Medicine
  31. Calorie Restriction Mimetics: Progress and Potential
    George S. Roth, Donald K. Ingram · 2015 · Healthy ageing and longevity
  32. Mitochondrial Function and Neurodegenerative Diseases
    Wilkins, Heather M., Weidling, Ian, Koppel, Scott, Wang, Xiaowan, von Schulze, Alex, Swerdlow, Russell H. · 2018 · The Molecular and Cellular Basis of Neurodegenerative Diseases
  33. A long-term ketogenic diet in young and aged rats has dissociable effects on prelimbic cortex and CA3 ensemble activity
    Abbi R. Hernandez, Maya E. Barrett, Katelyn N. Lubke, A. P. Maurer, S. Burke · 2023 · bioRxiv
  34. Targeting Mitochondria and Redox Dyshomeostasis in Brain Ageing: An Update
    Susana Cardoso, Paula Isabel Moreira · 2021 · Healthy ageing and longevity
  35. A machine learning-based holistic approach for the diagnosis of patients suffering from different conditions within the Alzheimer's disease spectrum
    N. Massetti, Alberto Granzotto, M. Bomba, S. Pizzi, A. Mosca, Reinhold Scherer, M. Onofrj, S. Sensi · 2020 · medRxiv
  36. Lifestyle Factors, Mitochondrial Dynamics, and Neuroprotection
    Katheryn Broman, Abigail U. Davis, Jordan May, Hana Park · 2019 · IntechOpen eBooks
  37. Regulation
    Herrero Jone, Castro Begoña · 2019 · Systemic Risk
  38. Suppression of the dihydrolipoamide dehydrogenase gene ( dld-1 ) protects against the toxicity of human amyloid beta in C. elegans model of Alzheimer’s disease
    Waqar Ahmad · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  39. Transcriptome analysis reveals organ-specific effects of 2-deoxyglucose treatment in healthy mice
    Ann Wells, John J. Wilson, Sarah E. Heuer, John D. Sears, Jian Ning Wei, Raghav Pandey, Mauro W. Costa, Catherine Cook Kaczorowski, Derry C. Roopenian, Chih‐Hao Chang et al. · 2024 · PLoS ONE
  40. Metabolic shift toward ketosis in asocial cavefish increases social-like affinity
    Motoko Iwashita, Amity Tran, Marianne Garcia, Jia Cashon, Devanne Burbano, Vanessa dos Santos Chiappetta Nogue Salgado, Malia Hasegawa, Rhoada Balmilero-Unciano, Kaylah Politan, Miki Wong et al. · 2023 · BMC Biology
  41. Modulatory role of ketogenic diet on neuroinflammation; a possible drug naïve strategy to treatment of Parkinson’s disease
    S. Shaafi, J. Mahmoudi, S. Najmi, S. Sadigh-Eteghad, M. Farhoudi, H. Aliasgharpour · 2015
  42. Targeting Alzheimer's disease neuronal mitochondria as a therapeutic approach
    Isaac G. Onyango, Gorazd Bernard Stokin · 2020 · Elsevier eBooks
  43. Alzheimer’s disease, epigenetics, and exercise
    Stuart M. Raleigh, Tom Cullen · 2021 · Elsevier eBooks
  44. Roles of glycolytic and pyruvate metabolism enzymes in Alzheimer’s disease glycometabolic reprogramming and their therapeutic potential
    Minmin Chen, Changmin Zuo, Runzhi Li, Jinlong Zhang, Zeshan Yao, Liping Li, Li Cheng · 2026 · Discover Neuroscience
  45. Microglial immunometabolism in Alzheimer's disease: A stage-resolved trajectory from adaptive remodeling to the metabolic paradox
    Yue Zou, Yi Ou, Hang Zhao, Ge Chen, Zhong Chen, Yunqin Li, Junliang Jiang · 2026 · Biomedicine & Pharmacotherapy
  46. Energy stress activates AMPK to suppress ferroptosis in neurodegenerative proteinopathies
    Yuanyuan Yong, Yu-Xin Hu, Qian Feng, Xiao-Gang Zhou, Lu Yu, Da-Lian Qin, Jia-Ning Mi, Jian-Ming Wu, Jian-Xin Liu, An-Guo Wu · 2026 · International Journal of Molecular Medicine
  47. Dietary Impact on Neuronal Autophagy Control and Brain Health
    Claudia Ntsapi, André du Toit, Ben Loos · 2019 · IntechOpen eBooks
  48. Glucose facilitates Aβ oligomerization and tau phosphorylation in C. elegans model of Alzheimer’s disease
    Waqar Ahmad · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Metabolic study of Alzheimer’s disease using mutant C. elegans
    Waqar Ahmad · 2017 · The University of Queensland
  50. Ketogenic Diets for the Treatment of Neurologic Disease
    Christa Whelan Habela, Eric Heath Kossoff · 2015 · Wiley eBooks
  51. Magnetic Resonance Spectroscopy of Metabolic Changes in the Brains of Mice Given 2-Deoxy-D-Glucose and Lipopolysaccharide
    M. Moshkin, A. Akulov, D. Petrovskii, O. Saik, E. D. Petrovskii, A. Savelov, I. Koptyug · 2014 · Neuroscience and Behavioral Physiology
  52. Ketone Body Metabolism Preserves Hepatic Function during Adaptation to Birth and in Overnutrition
    D. Cotter · 2015