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Cited by 66Amyloidosis: Diagnosis, Treatment, OutcomesAlzheimer's disease research and treatmentsAtherosclerosis and Cardiovascular Diseases

Human apolipoprotein A-I-derived amyloid: its association with atherosclerosis

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Ramella, Nahuel A., Rimoldi, Omar J., Prieto, Eduardo D., Schinella, Guillermo R., Sanchez, Susana A., Jaureguiberry, María S., Vela, María E., Ferreira, Sergio T. +1 more·2011·PLoS ONE
DOI 10.1371/journal.pone.0022532PMC PMC3139661
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Abstract

Amyloidoses constitute a group of diseases in which soluble proteins aggregate and deposit extracellularly in tissues. Nonhereditary apolipoprotein A-I (apoA-I) amyloid is characterized by deposits of nonvariant protein in atherosclerotic arteries. Despite being common, little is known about the pathogenesis and significance of apoA-I deposition. In this work we investigated by fluorescence and biochemical approaches the impact of a cellular microenvironment associated with chronic inflammation on the folding and pro-amyloidogenic processing of apoA-I. Results showed that mildly acidic pH promotes misfolding, aggregation, and increased binding of apoA-I to extracellular matrix elements, thus favoring protein deposition as amyloid like-complexes. In addition, activated neutrophils and oxidative/proteolytic cleavage of the protein give rise to pro amyloidogenic products. We conclude that, even though apoA-I is not inherently amyloidogenic, it may produce non hereditary amyloidosis as a consequence of the pro-inflammatory microenvironment associated to atherogenesis.

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Authors
Ramella, N. A., Rimoldi, O. J., Prieto, E. D., Schinella, G. R., Sanchez, S. A., Jaureguiberry, M. S., Vela, M. E., Ferreira, S. T., & Tricerri, M. A.
Affiliations
  • Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
  • Universidad Nacional de La Plata (AR)
  • Universidade Federal do Rio de Janeiro (BR)
Corresponding author
Tricerri, M. Alejandra
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2011-07-19
Volume
6
Issue
7
Pages
e22532
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0022532
PMC
PMC3139661
OpenAlex
W2085498526
Cited by
66
References
3
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 10 · 2019: 1 · 2018: 4 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 3 · 2013: 3 · 2012: 6
FWCI
1.69
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
  • Americanae (AECID Library) (submittedVersion, other-oa)
  • Americanae (AECID Library) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
  • Greater South Information System
Funders
  • Consejo Nacional de Investigaciones Científicas y Técnicas (PIP 112)
  • Universidad Nacional de La Plata
  • National Institutes of Health
  • National Center for Research Resources (P41RR003155, 5P41 RR03155)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Amyloidosis: Diagnosis, Treatment, Outcomes
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
apolipoprotein A-I, amyloidosis, atherosclerosis, protein misfolding, protein aggregation, chronic inflammation, low pH, extracellular matrix binding, neutrophils, oxidative cleavage, proteolytic cleavage, atherogenesis
MeSH terms
Amyloid, Anilino Naphthalenesulfonates, Animals, Cholesterol, Cricetulus, Cricetinae, Heparin, Humans, Hydrogen-Ion Concentration, Hypochlorous Acid, Oxidation-Reduction, Protein Binding, Solvents, Tetradecanoylphorbol Acetate, Thiazoles, Tryptophan, CHO Cells, Apolipoprotein A-I, Protein Structure, Secondary, Protein Folding, Neutrophil Activation, Protein Structure, Quaternary, Atherosclerosis, Benzothiazoles, Matrix Metalloproteinase 12, Protein Stability, Proteolysis

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