The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Antibiotic Resistance Gene Abundances Correlate with Metal and Geochemical Conditions in Archived Scottish Soils
Open accessAbstract
The vast majority of antibiotic resistant genes (ARG) acquired by human pathogens have originated from the natural environment. Therefore, understanding factors that influence intrinsic levels of ARG in the environment could be epidemiologically significant. The selection for metal resistance often promotes AR in exposed organisms; however, the relationship between metal levels in nature and the intrinsic presence of ARG has not been fully assessed. Here, we quantified, using qPCR, the abundance of eleven ARG and compared their levels with geochemical conditions in randomly selected soils from a Scottish archive. Many ARG positively correlated with soil copper levels, with approximately half being highly significant (p<0.05); whereas chromium, nickel, lead, and iron also significantly correlated with specific ARG. Results show that geochemical metal conditions innately influence the potential for AR in soil. We suggest soil geochemical data might be used to estimate baseline gene presence on local, regional and global scales within epidemiological risk studies related to AR transmission from the environment.
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Citations
Cites
SOS response promotes horizontal dissemination of antibiotic resistance genes
Beaber, J. W., Hochhut, B., & Waldor, M. K. (2004) · Nature · doi:10.1038/nature02241 · Cited by 1,186
Cited by
Seiler, C., & Berendonk, T. U. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00399 · Cited by 1,018
Environmental antimicrobial resistance and its drivers: a potential threat to public health
Samreen, Ahmad, I., Malak, H. A., & Abulreesh, H. H. (2021) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2021.08.001 · Cited by 727
The Scourge of Antibiotic Resistance: The Important Role of the Environment
Finley, R. L., Collignon, P., Larsson, D. G. J., McEwen, S. A., Li, X.-Z., Gaze, W. H., Reid-Smith, R., Timinouni, M., Graham, D. W., & Topp, E. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit355 · Cited by 636
Self-citationImran, M., Das, K. R., & Naik, M. M. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2018.10.114 · Cited by 597
Hu, H.-W., Wang, J.-T., Li, J., Shi, X.-Z., Ma, Y.-B., Chen, D., & He, J.-Z. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.6b03383 · Cited by 312
Metadata
- Authors
- Knapp, C. W., McCluskey, S. M., Singh, B. K., Campbell, C. D., Hudson, G., & Graham, D. W.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-11-09
- Volume
- 6
- Issue
- 11
- Pages
- e27300
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W1975055934
- Cited by
- 394
- References
- 1
- FWCI
- 11.95
- Type
- journal article
- Language
- en
- Open access
- gold
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- Knapp, C. W., McCluskey, S. M., Singh, B. K., Campbell, C. D., Hudson, G., & Graham, D. W. (2011). Antibiotic Resistance Gene Abundances Correlate with Metal and Geochemical Conditions in Archived Scottish Soils. PLoS ONE. https://doi.org/10.1371/journal.pone.0027300
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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