Perineuronal Nets Play a Role in Regulating Striatal Function in the Mouse
Open accessAbstract
The striatum is the primary input nucleus of the basal ganglia, a collection of nuclei that play important roles in motor control and associative learning. We have previously reported that perineuronal nets (PNNs), aggregations of chondroitin-sulfate proteoglycans (CSPGs), form in the matrix compartment of the mouse striatum during the second postnatal week. This period overlaps with important developmental changes, including the attainment of an adult-like gait. Here, we investigate the identity of the cells encapsulated by PNNs, characterize their topographical distribution and determine their function by assessing the impact of enzymatic digestion of PNNs on two striatum-dependent behaviors: ambulation and goal-directed spatial learning. We show PNNs are more numerous caudally, and that a substantial fraction (41%) of these structures surrounds parvalbumin positive (PV+) interneurons, while approximately 51% of PV+ cells are ensheathed by PNNs. The colocalization of these structures is greatest in dorsal, lateral and caudal regions of the striatum. Bilateral digestion of striatal PNNs led to an increase in both the width and variability of hind limb gait. Intriguingly, this also resulted in an improvement in the acquisition rate of the Morris water maze. Together, these data show that PNNs are associated with specific elements of striatal circuits and play a key role in regulating the function of this important structure in the mouse.
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Bilateral digestion of striatal PNNs improves acquisition rate in Morris water maze.
“this also resulted in an improvement in the acquisition rate of the Morris water maze”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Lee et al., 2012
PNNs appear linked to particular striatal circuit components and are important for controlling striatal activity.
“These findings suggest that PNNs are associated with specific elements of striatal circuits and play a key role in regulating the function of this important structure (Lee et al., 2012)”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Lee et al., 2012
Bilateral digestion of striatal PNNs increases width and variability of hind limb gait.
“bilateral digestion of striatal PNNs was reported to increase both the width and variability of hind limb gait”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Lee et al., 2012
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References 66 · Cited by 47
Research works printed but not linked: 1
- [33]Gerfen CR Wilson CJ 1996 The basal ganglia. Integrated Systems of the CNS, Part III Amsterdam Elsevier Science 371 468
- Authors
- Lee, H., Leamey, C. A., & Sawatari, A.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Sawatari, Atomu
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-03-12
- Volume
- 7
- Issue
- 3
- Pages
- e32747
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3299692
- OpenAlex
- W2069762407
- Cited by
- 47
- References
- 66
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 3 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 7 · 2015: 2 · 2014: 2
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Rebecca L. Cooper Medical Research Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- perineuronal nets, striatum, chondroitin sulfate proteoglycans, parvalbumin interneurons, basal ganglia, gait, spatial learning, Morris water maze, enzymatic digestion, postnatal development, mice
- MeSH terms
- Animals, Basal Ganglia, Extracellular Matrix, Immunohistochemistry, Interneurons, Locomotion, Male, Mice, Inbred C57BL, Neuronal Plasticity, Chondroitin Sulfate Proteoglycans, Space Perception, Maze Learning, Lectins, Mice
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