Cited by 604Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesGastrointestinal motility and disorders

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Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-Induced Obese Mice

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Lam, Yan Y., Ha, Connie W. Y., Campbell, Craig R., Mitchell, Andrew J., Dinudom, Anuwat, Oscarsson, Jan, Cook, David I., Hunt, Nicholas H., Caterson, Ian D., Holmes, Andrew J., Storlien, Len H.·2012·PLoS ONE

DOI 10.1371/journal.pone.0034233PMC PMC3311621

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Abstract

We investigated the relationship between gut health, visceral fat dysfunction and metabolic disorders in diet-induced obesity. C57BL/6J mice were fed control or high saturated fat diet (HFD). Circulating glucose, insulin and inflammatory markers were measured. Proximal colon barrier function was assessed by measuring transepithelial resistance and mRNA expression of tight-junction proteins. Gut microbiota profile was determined by 16S rDNA pyrosequencing. Tumor necrosis factor (TNF)-α and interleukin (IL)-6 mRNA levels were measured in proximal colon, adipose tissue and liver using RT-qPCR. Adipose macrophage infiltration (F4/80⁺) was assessed using immunohistochemical staining. HFD mice had a higher insulin/glucose ratio (P = 0.020) and serum levels of serum amyloid A3 (131%; P = 0.008) but reduced circulating adiponectin (64%; P = 0.011). In proximal colon of HFD mice compared to mice fed the control diet, transepithelial resistance and mRNA expression of zona occludens 1 were reduced by 38% (P<0.001) and 40% (P = 0.025) respectively and TNF-α mRNA level was 6.6-fold higher (P = 0.037). HFD reduced Lactobacillus (75%; P<0.001) but increased Oscillibacter (279%; P = 0.004) in fecal microbiota. Correlations were found between abundances of Lactobacillus (r = 0.52; P = 0.013) and Oscillibacter (r = -0.55; P = 0.007) with transepithelial resistance of the proximal colon. HFD increased macrophage infiltration (58%; P = 0.020), TNF-α (2.5-fold, P<0.001) and IL-6 mRNA levels (2.5-fold; P = 0.008) in mesenteric fat. Increased macrophage infiltration in epididymal fat was also observed with HFD feeding (71%; P = 0.006) but neither TNF-α nor IL-6 was altered. Perirenal and subcutaneous adipose tissue showed no signs of inflammation in HFD mice. The current results implicate gut dysfunction, and attendant inflammation of contiguous adipose, as salient features of the metabolic dysregulation of diet-induced obesity.

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Introducing mothur: Open-Source, Platform-Independent, Community-Supported Software for Describing and Comparing Microbial Communities
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 21,481 · cited 3×
“bTEFAP raw data were processed using Mothur [32] unless stated otherwise.”
MethodInfluential
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · cited 1×
“Finally, there is an emerging body of literature demonstrating an association between altered gut microbiota profile and obesity in humans (see [14] and [15] for a recent review) which, from pioneering work on rodents [12,16,17], appears to be causative.”
Background
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · cited 5×
“Impaired gut barrier function, along with gut inflammation, have also been observed in both genetic [11] and dietary [12,13] models of obesity.”
BackgroundInfluential
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · cited 1×
“The increased transcriptional expression of pro-inflammatory factors in the mesenteric fat may be a consequence of the preferential infiltration of macrophages with a pro-inflammatory phenotype [60].”
Background
Bacterial Community Variation in Human Body Habitats Across Space and Time
Costello, E. K., Lauber, C. L., Hamady, M., Fierer, N., Gordon, J. I., & Knight, R. (2009) · Science · doi:10.1126/science.1177486 · Cited by 3,231 · cited 1×
“Parameters used to filter sequences for analysis were based upon published studies [33,34].”
Method
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615 · cited 1×
“Finally, there is an emerging body of literature demonstrating an association between altered gut microbiota profile and obesity in humans (see [14] and [15] for a recent review) which, from pioneering work on rodents [12,16,17], appears to be causative.”
Background
Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science · doi:10.1126/science.1179721 · Cited by 2,068 · cited 1×
“, appears to be causative. The cross-linkage between gut microbiota, metabolic dysfunction and the immune system is best illustrated in Toll-like receptor-5 knockout mice which develop spontaneous colitis, insulin resistance, hyperlipidemia and increased visceral fat deposition”
Background
Dominant and diet-responsive groups of bacteria within the human colonic microbiota
Walker, A. W., Ince, J., Duncan, S. H., Webster, L. M., Holtrop, G., Ze, X., Brown, D., Stares, M. D., Scott, P., Bergerat, A., et al. (2011) · The ISME Journal · doi:10.1038/ismej.2010.118 · Cited by 1,632 · cited 1×
“diet-responsive in obese individuals [54] but to date little is known”
Background
Comparison of the Release of Adipokines by Adipose Tissue, Adipose Tissue Matrix, and Adipocytes from Visceral and Subcutaneous Abdominal Adipose Tissues of Obese Humans
Fain, J. N., Madan, A. K., Hiler, M. L., Cheema, P. S., & Bahouth, S. W. (2004) · Endocrinology · doi:10.1210/en.2003-1336 · Cited by 1,619 · cited 1×
“in the stromal-vascular fraction of fat depots [5,6].”
Background

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R Al-Sadi, 2010, IL-1[beta]-Induced Increase in Intestinal Epithelial Tight Junction Permeability Is Mediated by MEKK-1 Activation of Canonical NF-[kappa]B Pathway., The American Journal of Pathology, 177, 2310, 10.2353/ajpath.2010.100371 · DOI

Sorted by citations

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“In a previous animal study, high-fat diet was found to induce accumulation of mesenteric fat but not epididymal fat [9].”
Background
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Calorie restriction ameliorates hyperglycemia, modulates the disordered gut microbiota, and mitigates metabolic endotoxemia and inflammation in type 2 diabetic rats
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Background
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Ducray, H. A. G., Globa, L. P., Pustovyy, O. M., Morrison, E. E., Vodyanoy, V. J., & Sorokulova, I. B. (2019) · Journal of Applied Microbiology · doi:10.1111/jam.14361 · Cited by 52
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Background
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“Of note, differences in Oscillibacter have been found in prior studies of diet and obesity [13, 33, 39] that may be related to a higher consumption of fat [43].”
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Background
Effect of sulfate group on sulfated polysaccharides-induced improvement of metabolic syndrome and gut microbiota dysbiosis in high fat diet-fed mice.
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Antonioli, L., Pellegrini, C., Fornai, M., Tirotta, E., Gentile, D., Benvenuti, L., Giron, M., Caputi, V., Marsilio, I., Orso, G., et al. (2017) · Purinergic Signalling Purinergic Signalling · doi:10.1007/s11302-017-9577-0 · Cited by 38
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Background
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“This would wane allergic inflammation in the lungs (Lambrecht and Hammad 2012).”
Background
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Background
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Background
A prospective analysis of dietary fiber intake and mental health quality of life in the Iowa Women’s Health Study
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Milard, M., Penhoat, A., Durand, A., Buisson, C., Loizon, E., Meugnier, E., Bertrand, K., Joffre, F., Cheillan, D., Garnier, L., et al. (2019) · Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.12.007 · Cited by 36
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Background
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Background
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Background
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Guo, P., Wang, H., Ji, L., Song, P., & Ma, X. (2021) · Nutrients · doi:10.3390/nu13103515 · Cited by 35
β-Glucan Extracted from Highland Barley Alleviates Dextran Sulfate Sodium-Induced Ulcerative Colitis in C57BL/6J Mice
Chen, M., Tian, S., Li, S., Pang, X., Sun, J. Y., Zhu, X., Lv, F., Lu, Z., & Li, X. (2021) · Molecules · doi:10.3390/molecules26195812 · Cited by 41
Qing-Re-Xiao-Zheng Formula Modulates Gut Microbiota and Inhibits Inflammation in Mice With Diabetic Kidney Disease
Gao, Y., Yang, R., Guo, L., Wang, Y., Liu, W. J., Ai, S., Woon, T. H., Wang, Z., Zhai, Y., Wang, Z., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.719950 · Cited by 36
High housing density increases stress hormone- or disease-associated fecal microbiota in male Brandt's voles (Lasiopodomys brandtii)
Liu, J., Huang, S., Li, G., Zhao, J., Lu, W., & Zhang, Z. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104838 · Cited by 35
“Microbes from Oscillospira are reported to play an important role in mediating destruction of the intestinal epithelial barrier, and then leading to the translocation of gut bacteria in obesity (Lam et al., 2012).”
Background
Intestinal plasticity in response to nutrition and gastrointestinal surgery
Gall, M. L., Thenet, S., Aguanno, D., Jarry, A., Genser, L., Ribeiro‐Parenti, L., Joly, F., Ledoux, S., Bado, A., & Beyec, J. L. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy064 · Cited by 46
Interplay between colonic inflammation and tachykininergic pathways in the onset of colonic dysmotility in a mouse model of diet-induced obesity
Antonioli, L., Caputi, V., Fornai, M., Pellegrini, C., Gentile, D., Giron, M. C., Orso, G., Bernardini, N., Segnani, C., Ippolito, C., et al. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0166-2 · Cited by 44
The protective effects of melatonin on survival, immune response, digestive enzymes activities and intestinal microbiota diversity in Chinese mitten crab (Eriocheir sinensis) exposed to glyphosate.
Song, Y.-M., Song, X.-Z., Wu, M.-Y., Pang, Y., Shi, A.-Y., Shi, X., Niu, C., Cheng, Y.-X., & Yang, X.-Z. (2020) · Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · doi:10.1016/j.cbpc.2020.108845 · Cited by 33
Consumption of Goats’ Milk Protects Mice From Carbon Tetrachloride-Induced Acute Hepatic Injury and Improves the Associated Gut Microbiota Imbalance
Zhang, J., Wang, Z., Huo, D., & Shao, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01034 · Cited by 35
“Diets rich in saturated fat can cause the development of a lipogenic liver and is associated with a decrease in the abundance of Lactobacillus and an increase in the abundance of Oscillibacter in the gut microbiota (31).”
Background
Lacticaseibacillus rhamnosus Probio-M9-Driven Mouse Mammary Tumor-Inhibitory Effect Is Accompanied by Modulation of Host Gut Microbiota, Immunity, and Serum Metabolome
Zhang, W., Zhang, Y., Li, Y., Ma, D., Zhang, H., & Kwok, L. (2022) · Nutrients · doi:10.3390/nu15010005 · Cited by 34
“In fact, there is evidence supporting that the protective effect of probiotics (including Lactobacillus helveticus, Limosilactobacillus reuteri, Lactiplantibacillus plantarum, and Lacticaseibacillus casei Shirota) against breast cancer progression is via modulating the host immune system [24,25,58,59].”
Effects of heat-treated starch and protein from foxtail millet (Setaria italica) on type 2 diabetic mice.
Wang, H., Fu, Y., Zhao, Q.-Y., Liu, Z., Wang, C., Xue, Y., & Shen, Q. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.134735 · Cited by 32
High-Fat Diet-Induced Obesity Aggravates Food Allergy by Intestinal Barrier Destruction and Inflammation
Gu, Y.-J., Guo, X.-Y., Sun, S.-F., & Che, H. (2021) · International Archives of Allergy and Immunology · doi:10.1159/000517866 · Cited by 32
Colonic dysmotility associated with high‐fat diet‐induced obesity: Role of enteric glia
Antonioli, L., D’Antongiovanni, V., Pellegrini, C., Fornai, M., Benvenuti, L., di Carlo, A., van den Wijngaard, R. M., Caputi, V., Cerantola, S., Giron, M. C., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201901844r · Cited by 55
Dietary supplementation of soybean-derived sterols regulates cholesterol metabolism and intestinal microbiota in hamsters
Li, X., Zhang, Z., Cheng, J., Diao, C., Yan, Y., Liu, D., Wang, H., & Zheng, F. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.05.032 · Cited by 39
Mesenteric adipose tissue contributes to intestinal barrier integrity and protects against nonalcoholic fatty liver disease in mice
Wu, Z., Tan, J., Chi, Y., Zhang, F., Xu, J., Song, Y., Xu, C., Wu, N., & Liu, Y. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00079.2018 · Cited by 34
A study of the prebiotic-like effects of tomato juice consumption in rats with diet-induced non-alcoholic fatty liver disease (NAFLD)
García-Alonso, F. J., González‐Barrio, R., Martín‐Pozuelo, G., Hidalgo, N., NAVARRO-GONZÁLEZ, I., Masuero, D., Soini, E., Vrhovšek, U., & Periago, M. J. (2017) · Food & Function · doi:10.1039/c7fo00393e · Cited by 38
Integrated analysis of microbiome and transcriptome reveals the mechanisms underlying the chlorogenic acid-mediated attenuation of oxidative stress and systemic inflammatory responses via gut-liver axis in post-peaking laying hens
Hu, Z., Wu, L.-C., Lv, Y.-J., Ge, C.-Y., Luo, X., Zhan, S.-A., Huang, W.-C., Shen, X.-Y., Yu, D.-Y., & Liu, B. (2025) · Journal of Animal Science and Biotechnology · doi:10.1186/s40104-025-01216-7 · Cited by 31
“The increased Oscillibacter was closely associated with intestinal permeability and inflammation [79].”
Polysaccharide from Flammulina velutipes attenuates markers of metabolic syndrome by modulating the gut microbiota and lipid metabolism in high fat diet-fed mice
Zhao, R., Ji, Y., Chen, X., Hu, Q., & Zhao, L. (2021) · Food & Function · doi:10.1039/d1fo00534k · Cited by 45
Lactobacillus Mucosae Strain Promoted by a High-Fiber Diet in Genetic Obese Child Alleviates Lipid Metabolism and Modifies Gut Microbiota in ApoE-/- Mice on a Western Diet
Jiang, T., Wu, H., Yang, X., Li, Y., Zhang, Z., Chen, F., Zhao, L., & Zhang, C. (2020) · Microorganisms · doi:10.3390/microorganisms8081225 · Cited by 33
“Oscillibacter was found to be positively associated with increased permeability of mouse colon [57].”
Background
A role for whey-derived lactoferrin and immunoglobulins in the attenuation of obesity-related inflammation and disease
Brimelow, R. E., West, N. P., Williams, L. T., Cripps, A. W., & Cox, A. J. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.995264 · Cited by 43
“Animal studies have also demonstrated that high fat/sugar diets increase intestinal permeability, increase circulating LPS concentrations, and induce local and systemic inflammation (de La Serre et al., 2010; Lam et al., 2012; Martinez-Medina et al., 2014).”
Background
Causal Effects of Gut Microbiota on Age-Related Macular Degeneration: A Mendelian Randomization Study
Mao, D., Tao, B., Sheng, S., Jin, H. Z., Chen, W., Gao, H., Deng, J., Li, Z., Chen, F., Chan, S., et al. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.12.32 · Cited by 32
Review of gut nanotoxicology in mammals: Exposure, transformation, distribution and toxicity.
Huang, X.-Q., & Tang, M. (2021) · Science of the Total Environment · doi:10.1016/j.scitotenv.2021.145078 · Cited by 30
Gut microbiome-host interactions in driving environmental pollutant trichloroethene-mediated autoimmunity
Wang, H., Banerjee, N., Liang, Y., Wang, G., Hoffman, K. L., & Khan, M. F. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115597 · Cited by 32
Nutrition and microRNAs: Novel Insights to Fight Sarcopenia
Barbiera, A., Pelosi, L., Sica, G., & Scicchitano, B. M. (2020) · Antioxidants · doi:10.3390/antiox9100951 · Cited by 32
Uric acid and transforming growth factor in fructose-induced production of reactive oxygen species in skeletal muscle
Madlala, H. P., Maarman, G. J., & Ojuka, E. O. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuv111 · Cited by 35
Properties of myenteric neurones and mucosal functions in the distal colon of diet‐induced obese mice
Reichardt, F., Baudry, C., Gruber, L., Mazzuoli‐Weber, G., Moriez, R., Scherling, C., Kollmann, P., Daniel, H., Kisling, S., Haller, D., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.262733 · Cited by 29
“The Journal of Physiology C© 2013 The Physiological Society studies have highlighted increased intestinal permeability and signs of intestinal inflammation in both DIO rats and mice (Lam et al. 2012; Raybould, 2012; Stenman et al. 2012).”
Background
The role of gut microbiota and bacterial translocation in the pathogenesis and management of type 2 diabetes mellitus: Mechanisms, impacts, and dietary therapeutic strategies
Murugesan, R., Kumar, J. S., Leela, K. V., Meenakshi, S., Srivijayan, A., Thiruselvam, S., Satheesan, A., & Chaithanya, V. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.114838 · Cited by 30
Microbial lipopolysaccharide‐induced inflammation contributes to cognitive impairment and white matter lesion progression in diet‐induced obese mice with chronic cerebral hypoperfusion
Inaba, T., Yamashiro, K., Kurita, N., Ueno, Y., Miyamoto, N., Hira, K., Nakajima, S., Kijima, C., Nakaguro, R., Urabe, T., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14301 · Cited by 32
Kombuchas from Green and Black Tea Modulate the Gut Microbiota and Improve the Intestinal Health of Wistar Rats Fed a High-Fat High-Fructose Diet
Costa, M. A. D. C., Moreira, L. D. P. D., Duarte, V. D. S., Cardoso, R. R., José, V. P. B. D. S., da Silva, B. P., Grancieri, M., Corich, V., Giacomini, A., Bressan, J., et al. (2022) · Nutrients · doi:10.3390/nu14245234 · Cited by 40
“The Western diet style, despite not having a specific definition, is an unhealthy diet generally composed of a high amount of saturated fat and fructose [1], which is involved in metabolic disorders such as obesity and metabolic syndrome [2,3], as well as in alterations in the gut microbiota profile [4].”
Background
Keeping It Local in Metabolic Disease: Adipose Tissue Paracrine Signaling and Insulin Resistance
KAHN, D. E., & Bergman, B. C. (2022) · Diabetes · doi:10.2337/dbi21-0020 · Cited by 34
Conjugated linoleic acid ameliorates hepatic steatosis by modulating intestinal permeability and gut microbiota in ob/ob mice
Gao, S., He, Y.-Y., Zhang, L., Liu, L., Qu, C.-F., Zheng, Z., & Miao, J.-L. (2022) · Food & Nutrition Research · doi:10.29219/fnr.v66.8226 · Cited by 29
“Previous animal experiments suggest that higher intestinal permeability and subsequent intraportal LPS infusion are major mechanisms of fatty liver disease (38).”
Background
Roles of gastrointestinal polypeptides in intestinal barrier regulation
Xie, X., Geng, C., Li, X., Liao, J., Li, Y., Guo, Y., & Wang, C. (2022) · Peptides · doi:10.1016/j.peptides.2022.170753 · Cited by 29
Ethnic Differences Shape the Alpha but Not Beta Diversity of Gut Microbiota from School Children in the Absence of Environmental Differences
Liu, K., Zhang, Y., Li, Q., Li, H., Long, D., Yan, S., Huang, W., Long, R., & Huang, X. (2020) · Microorganisms · doi:10.3390/microorganisms8020254 · Cited by 33
“studies have reported that Oscillibacter make potentially substantial contributions to the development of metabolic diseases and gut dysfunction [39,40].”
Background
Influence of Maternal Inulin-Type Prebiotic Intervention on Glucose Metabolism and Gut Microbiota in the Offspring of C57BL Mice
Zhang, Q., Xiao, X., Zheng, J., Li, M., Yu, M., Ping, F., Wang, T., & Wang, X. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00675 · Cited by 30
“Oscillibacter was strongly associated with the diabetic phenotype (78) and also positively correlated with gut permeability (79).”
Background
Spinach consumption ameliorates the gut microbiota and dislipaemia in rats with diet-induced non-alcoholic fatty liver disease (NAFLD)
Elvira-Torales, L. I., Periago, M. J., González‐Barrio, R., Hidalgo, N., NAVARRO-GONZÁLEZ, I., Gómez-Gallego, C., Masuero, D., Soini, E., Vrhovšek, U., & García-Alonso, F. J. (2019) · Food & Function · doi:10.1039/c8fo01630e · Cited by 38
The Anti-Inflammatory Effect and Mucosal Barrier Protection of Clostridium butyricum RH2 in Ceftriaxone-Induced Intestinal Dysbacteriosis
Li, Y., Liu, M., Liu, H., Sui, X., Liu, Y., Wei, X., Liu, C., Cheng, Y., Ye, W., Gao, B., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.647048 · Cited by 39
“The genus Oscillibacter was found in human gut microbiota related to a disease or pathologic state (Mondot et al., 2011; Lam et al., 2012).”
Background
Implications of Tributyrin on Gut Microbiota Shifts Related to Performances of Weaning Piglets
Miragoli, F., Patrone, V., Prandini, A., Sigolo, S., Dell’Anno, M., Rossi, L., Senizza, A., Morelli, L., & Callegari, M. L. (2021) · Microorganisms · doi:10.3390/microorganisms9030584 · Cited by 28
“In the same study, the Oscillibacter genus was associated with improved weight gain [47].”
Background
The effects of antibiotics and melatonin on hepato-intestinal inflammation and gut microbial dysbiosis induced by a short-term high-fat diet consumption in rats
Yıldırım, A., Tamer, S. A., Sahin, D., Bağrıaçık, F., Kahraman, M. M., Onur, N. D., Çayırlı, Y. B., Çilingir‐Kaya, Ö. T., Aksu, B., Akdenız, E., et al. (2019) · British Journal Of Nutrition · doi:10.1017/s0007114519001466 · Cited by 33
“obesogenic diet induced colonic inflammation, impaired gut barrier function along with an altered profile of faecal microbiota, while the other fat depots have showed no signs of inflammation, emphasising that gut dysfunction is the major component of HFD-induced metabolic alterations(57).”
Background
Effects of honey from Mimosa quadrivalvis L. (malícia) produced by the Melipona subnitida D. (jandaíra) stingless bee on dyslipidaemic rats
Bezerra, M. L. R., de Souza, E. L., de Sousa, J. M. B., Lima, M. D. S., Alves, A. F., Almeida, M. D. G., Alves, R. C., de Araújo, E. V., Soares, N. L., Araújo‐Silva, G., et al. (2018) · Food & Function · doi:10.1039/c8fo01044g · Cited by 32
The Role of the Manipulation of the Gut Microbiota in Obesity
Million, M., & Raoult, D. (2012) · Current Infectious Disease Reports · doi:10.1007/s11908-012-0301-5 · Cited by 29
“The existence of apparently paradoxical significant results that indicate a correlation between a highfat diet and decreased Lactobacillus levels [23, 24] does not contradict the role of Lactobacillus in the regulation of weight but stresses the importance of species-level analyses of the Lactobacillus in the microbio…”
Result
Effects of the Ketogenic Diet on Microbiota Composition and Short-Chain Fatty Acids in Women with Overweight/Obesity
Akansel, M. G., Baş, M., Gençalp, C., Kahrıman, M., Şahin, E., Öztürk, H., Gür, G., & Gür, C. (2024) · Nutrients · doi:10.3390/nu16244374 · Cited by 27
“The fact that these factors could not be controlled is another limitation of this study.”
Effects of High-Fat Diet at Two Energetic Levels on Fecal Microbiota, Colonic Barrier, and Metabolic Parameters in Dogs
Moinard, A., Payen, C., Ouguerram, K., André, A., Hernandez, J. L., Drut, A., Biourge, V. C., Suchodolski, J. S., Flanagan, J., Nguyen, P., et al. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.566282 · Cited by 32
Plasma concentrations of zonulin are elevated in obese men with fatty liver disease
Kim, A., & Ko, H. (2018) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s163062 · Cited by 32
“Lam et al 18 reported that high-fat diets increase the concentrations of Gram-negative bacteria containing LPS on the intestinal walls.”
Characterization of TGF-β expression and signaling profile in the adipose tissue of rats fed with high-fat and energy-restricted diets
Sousa‐Pinto, B., Gonçalves, L., Rodrigues, A. R., Tomada, I., Almeida, H., Neves, D., & Gouveia, A. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.07.017 · Cited by 30
“Regional differences verified within the AT are thought to be also related with paracrine influences from organs nearby, which might be important to the inflammatory profile of obesity [13,51].”
Background
Microbiome and metabolic disorders related to obesity: Which lessons to learn from experimental models?
Neyrinck, A. M., Schüppel, V. L., Lockett, T. J., Haller, D., & Delzenne, N. M. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.08.012 · Cited by 26
Obesity and Gut’s Dysbiosis Promote Neuroinflammation, Cognitive Impairment, and Vulnerability to Alzheimer’s disease: New Directions and Therapeutic Implications
Daulatzai, M. A. (2014) · Journal of Molecular and Genetic Medicine · doi:10.4172/1747-0862.s1-005 · Cited by 22
“The reciprocal nature of the regulation of the immune system and gut microbiota is at the core in terms of dysfunctions involved in the pathogenesis of obesity and obesity-related disorders [29-34].”
Background
Habitats Show More Impacts Than Host Species in Shaping Gut Microbiota of Sympatric Rodent Species in a Fragmented Forest
Teng, Y., Yang, X., Li, G., Zhu, Y., & Zhang, Z. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.811990 · Cited by 30
Microbiota-Associated Therapy for Non-Alcoholic Steatohepatitis-Induced Liver Cancer: A Review
Chen, Y., Wu, W., & Wu, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175999 · Cited by 29
The DNA Sensor AIM2 Protects against Streptozotocin-Induced Type 1 Diabetes by Regulating Intestinal Homeostasis via the IL-18 Pathway
Leite, J. A., Pessenda, G., Guerra‐Gomes, I. C., de Santana, A. K. M., Pereira, C. A., Costa, F. R. C., Ramos, S. G., Zamboni, D. S., Faria, A. M. C., de Almeida, D. C., et al. (2020) · Cells · doi:10.3390/cells9040959 · Cited by 30
Profiling of aminoxyTMT-labeled bovine milk oligosaccharides reveals substantial variation in oligosaccharide abundance between dairy cattle breeds
Robinson, R. C., Poulsen, N. A., Colet, E., Duchene, C., Larsen, L. B., & Barile, D. (2019) · Scientific Reports · doi:10.1038/s41598-019-41956-x · Cited by 30
Bardoxolone Methyl Prevents High-Fat Diet-Induced Colon Inflammation in Mice
Dinh, C. H. L., Yu, Y., Szabo, A., Zhang, Q., Zhang, P., & Huang, X. (2016) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155416631803 · Cited by 25
“Macrophage infiltration is a common characteristic of inflammation in the colons of diet-induced obese mice (Erdelyi et al. 2009; Lam et al. 2012; Liu et al. 2012).”
Background
High-Fat Diet Promotes Neuronal Loss in the Myenteric Plexus of the Large Intestine in Mice
Beraldi, E., Soares, A., Borges, S., de Souza, A. C. D. S., Natali, M., Bazotte, R., & Buttow, N. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3402-1 · Cited by 26
“Studies that used animal models of genetic and highfat-induced obesity reported an increase in the production of tumor necrosis factor a and interleukin-6 by adipose tissue [5, 6] and the intestine [7], and an increase in the activation of Toll-like receptor (TLR) and nuclear factor jB signaling pathways [8].”
Background
Role of gut-liver axis and glucagon-like peptide-1 receptor agonists in the treatment of metabolic dysfunction-associated fatty liver disease
Rochoń, J., Kalinowski, P., Szymanek-Majchrzak, K., & Grąt, M. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i23.2964 · Cited by 41
“This finding may serve as an alternative contributor to the advancement of MAFLD[42].”
Influential

Authors: Lam, Y. Y., Ha, C. W. Y., Campbell, C. R., Mitchell, A. J., Dinudom, A., Oscarsson, J., Cook, D. I., Hunt, N. H., Caterson, I. D., Holmes, A. J., & Storlien, L. H.
Affiliations: The University of Sydney (AU)
Corresponding author: Lam, Yan Y.
ORCID: Lam, Yan Y.
Ha, Connie W. Y.
Campbell, Craig R.
Mitchell, Andrew J.
Oscarsson, Jan
Hunt, Nicholas H.
Caterson, Ian D.
Holmes, Andrew J.
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2012-03-23
Volume: 7
Issue: 3
Pages: e34233
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0034233
PMC: PMC3311621
OpenAlex: W2000450805
Cited by: 604
References: 72
Citations by year: 2026: 24 · 2025: 33 · 2024: 39 · 2023: 58 · 2022: 62 · 2021: 59 · 2020: 58 · 2019: 53 · 2018: 44 · 2017: 41 · 2016: 41 · 2015: 34 · 2014: 29 · 2013: 21 · 2012: 8
FWCI: 11.84
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Figshare (submittedVersion, cc-by)
Minerva Access (University of Melbourne) (submittedVersion, cc-by)
Funders: Medical Research Council
National Health and Medical Research Council (633240)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: diet-induced obesity, high saturated fat diet, intestinal permeability, gut microbiota, mesenteric fat inflammation, visceral adipose tissue, metabolic dysfunction, tight junctions, ZO-1, TNF-α, interleukin-6, adipose tissue macrophages, Lactobacillus, Oscillibacter, adiponectin, serum amyloid A
MeSH terms: Animals, Diet, Female, Inflammation, Intestinal Mucosa, Intestines, Mesentery, Mice, Inbred C57BL, Permeability, Mice

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Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-Induced Obese Mice

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