Maternal Diet Modulates Placenta Growth and Gene Expression in a Mouse Model of Diabetic Pregnancy
Open accessAbstract
Unfavorable maternal diet during pregnancy can predispose the offspring to diseases later in life, such as hypertension, metabolic syndrome, and obesity. However, the molecular basis for this phenomenon of "developmental programming" is poorly understood. We have recently shown that a diet nutritionally optimized for pregnancy can nevertheless be harmful in the context of diabetic pregnancy in the mouse, associated with a high incidence of neural tube defects and intrauterine growth restriction. We hypothesized that placental abnormalities may contribute to impaired fetal growth in these pregnancies, and therefore investigated the role of maternal diet in the placenta. LabDiet 5015 diet was associated with reduced placental growth, commencing at midgestation, when compared to pregnancies in which the diabetic dam was fed LabDiet 5001 maintenance chow. Furthermore, by quantitative RT-PCR we identify 34 genes whose expression in placenta at midgestation is modulated by diet, diabetes, or both, establishing biomarkers for gene-environment interactions in the placenta. These results implicate maternal diet as an important factor in pregnancy complications and suggest that the early phases of placenta development could be a critical time window for developmental origins of adult disease.
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Even relatively modest changes in dietary composition within the range recommended for rodent pregnancy can alter placental weight and zonal proportions near term.
“Even relative modest changes in dietary composition within the range recommended for rodent pregnancy can alter placental weight and zonal proportions near term (119, 301).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [301]
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References 32 · Cited by 36
- Authors
- Kappen, C., Kruger, C., MacGowan, J., & Salbaum, J. M.
- Affiliations
- Pennington Biomedical Research Center (US)
- Corresponding author
- Kappen, Claudia
- ORCID
- Kappen, Claudia
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-06-11
- Volume
- 7
- Issue
- 6
- Pages
- e38445
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3372526
- OpenAlex
- W1993663762
- Cited by
- 36
- References
- 32
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 3 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 1
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK072476)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD37804, R01HD037804, R01HD055528)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- maternal diet, diabetes in pregnancy, placental gene expression, developmental origins of adult disease, developmental programming, fetal growth restriction, gene-environment interaction, placental biomarkers, pregnancy complications
- MeSH terms
- Analysis of Variance, Animals, Animal Feed, Animal Nutritional Physiological Phenomena, Diabetes Mellitus, Experimental, Diet, Female, Placenta, Placentation, Pregnancy, Cluster Analysis, DNA Primers, Gene Expression Regulation, Developmental, Maternal Nutritional Physiological Phenomena, Mice, Real-Time Polymerase Chain Reaction
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