Metastatic Pancreatic Cancer Is Dependent on Oncogenic Kras in Mice

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Items 101–179 of 179

  1. Serotonin uptake is required for Rac1 activation in Kras‐induced acinar‐to‐ductal metaplasia in the pancreas
    Enrica Saponara, Michele Visentin, Francesco Baschieri, Gitta Maria Seleznik, Paola Martinelli, Iréne Esposito, Johanna Buschmann, Rong Chen, Rossella Parrotta, Nathalie Borgeaud et al. · 2018 · The Journal of Pathology
  2. BRAF-Driven Pancreatic Cancer: Prevalence, Molecular Features, and Therapeutic Opportunities
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  3. Persistent ERK/MAPK Activation Promotes Lactotrope Differentiation and Diminishes Tumorigenic Phenotype
    Allyson K. Roof, Tammy Trudeau, Crystal Lynna Gomez, Marshall Scott Lucia, Arthur Gutierrez‐Hartmann · 2014 · Molecular Endocrinology
  4. The Bromodomain Inhibitor, INCB057643, Targets Both Cancer Cells and the Tumor Microenvironment in Two Preclinical Models of Pancreatic Cancer
    Ana S. Leal, Phillip Liu, Teresa Krieger-Burke, Bruce Ruggeri, Karen T. Liby · 2020 · Cancers
  5. Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models
    Brian T. DeCant, Daniel R. Principe, Carmen E. Guerra, Marina Pasca di Magliano, Paul J. Grippo · 2014 · Frontiers in Physiology
  6. KRas4B-PDE6δ complex stabilization by small molecules obtained by virtual screening affects Ras signaling in pancreatic cancer
    Diana Casique‐Aguirre, Paola Briseño-Díaz, Ponciano García‐Gutiérrez, Claudia Haydée González-De la Rosa, Reyna Sara Quintero Barceinas, Arturo Rojo‐Domínguez, Irene Vergara, Luis A. Medina, José Correa‐Basurto, Martiniano Bello et al. · 2018 · BMC Cancer
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    Biswajit Das, Shantibhusan Senapati · 2019 · Journal of Experimental & Clinical Cancer Research
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    Cristina Angela Metildi, Sharmeela Kaushal, Robert M. Hoffman, Michael Bouvet · 2013 · Journal of Surgical Research
  9. FAK promotes stromal PD-L2 expression associated with poor survival in pancreatic cancer
    Catherine Davidson, David Taggart, Andrew H. Sims, David W. Lonergan, Marta Canel, Alan Serrels · 2022 · British Journal of Cancer
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    Arthur Brannon, Donovan Drouillard, Nina G. Steele, Shadae Schoettle, Ethan V. Abel, Howard C. Crawford, Marina Pasca di Magliano · 2020 · Scientific Reports
  11. A PET Imaging Strategy for Interrogating Target Engagement and Oncogene Status in Pancreatic Cancer
    Kelly E. Henry, Megan M. Dacek, Thomas R. Dilling, Jonathan D. Caen, Ian L. Fox, Michael J. Evans, Jason Stuart Lewis · 2018 · Clinical Cancer Research
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    Tao Xia, Xiaoyi Chen, You-Ni Zhang · 2021 · Molecular and Cellular Biochemistry
  13. KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells
    Angela Mathison, Romica Kerketta, Thiago M. de Assuncao, Elise N. Leverence, Atefeh Zeighami, Guillermo Urrutia, Timothy J. Stodola, Marina Pasca di Magliano, Juan Iovanna, Michael T. Zimmermann et al. · 2021 · Genome biology
  14. Extracellular vesicles in Inter-Kingdom communication in gastrointestinal cancer.
    Yi Chen, Yansong Xu, Huage Zhong, Hao Yuan, Fangfang Liang, Junjie Liu, Weizhong Tang · 2021 · PubMed Central
  15. RAS specific protease induces irreversible growth arrest via p27 in several KRAS mutant colorectal cancer cell lines
    Caleb K. Stubbs, Marco Biancucci, Vania Vidimar, K.J.F. Satchell · 2021 · Scientific Reports
  16. Reshaping the Tumor Microenvironment of KRASG12D Pancreatic Ductal Adenocarcinoma with Combined SOS1 and MEK Inhibition for Improved Immunotherapy Response
    Robert J. Norgard, Pratha Budhani, Sarah A. O’Brien, Youli Xia, Jessica N. Egan, Brianna Flynn, Joshua R. Tagore, Joseph Seco, Gregory W. Peet, Ania Mikucka et al. · 2024 · Cancer Research Communications
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  18. Anoikis-Related Gene Signature for Prognostication of Pancreatic Adenocarcinoma: A Multi-Omics Exploration and Verification Study
    Jin Zhang, Xuesong Li, Yi Lu, Guowen Wang, Ying Ma · 2023 · Cancers
  19. A Novel Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth in Mouse Models of GI Cancer
    Foote, Jeremy B., Mattox, Tyler E., Keeton, Adam B., Chen, Xi, Smith, Forrest, Berry, Kristy L., Holmes, Thomas, Wang, Junwei, Huang, Chung-Hui, Ward, Antonio B. et al. · 2023
  20. Pharmacotherapeutic Management of Pancreatic Ductal Adenocarcinoma: Current and Emerging Concepts
    Dietrich Alexander Ruess, Kıvanç Görgülü, Sonja M. Wörmann, Hana Algül · 2017 · Drugs & Aging
  21. Synthetic Vulnerabilities in the KRAS Pathway
    Marta Román, Elizabeth E. Hwang, Alejandro Sweet-Cordero · 2022 · Cancers
  22. The KRAS signaling pathway's impact on the characteristics of pancreatic cancer cells
    Meiyan Chen, Meiyan Chen, Yuka Fu, Jingyi Zhang · 2023 · Pathology - Research and Practice
  23. The GSK3 kinase and LZTR1 protein regulate the stability of Ras family proteins and the proliferation of pancreatic cancer cells
    Chitra Palanivel, Neha Chaudhary, Parthasarathy Seshacharyulu, Jesse L. Cox, Ying Yan, Surinder K. Batra, Michel M. Ouellette · 2022 · Neoplasia
  24. Murine Models of Pancreatitis Leading to the Development of Pancreatic Cancer
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    Rahul Agrawal, Kedar Nath Natarajan · 2023 · Advances in cancer research
  26. Suppression of the KRAS-NRF2 axis shifts arginine into the phosphocreatine energy system in pancreatic cancer cells
    Eros Di Giorgio, Himanshi Choudhary, Annalisa Ferino, Ylenia Cortolezzis, Emiliano Dalla, Francesca D’Este, Marina Comelli, Valentina Rapozzi, Luigi Emilio Xodo · 2023 · iScience
  27. Utilizing Salmonella to treat solid malignancies
    Nancy D. Ebelt, Edwin Ramos Manuel · 2017 · Journal of Surgical Oncology
  28. Co-dependency between KRAS addiction and ARHGEF2 promotes an adaptive escape from MAPK pathway inhibition
    Oliver A. Kent, María José Sandí, Robert K. Rottapel · 2017 · Small GTPases
  29. The occurrence of prion protein in surgically resected pancreatic adenocarcinoma
    Matteo Bianchini, Maria Anita Giambelluca, Maria Concetta Scavuzzo, Gregorio Di Franco, Simone Guadagni, Matteo Palmeri, Niccolò Furbetta, Desirée Gianardi, Niccola Funel, Luca Emanuele Pollina et al. · 2020 · Pancreatology
  30. Tumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinoma
    Urszula N. Wasko, Jingjing Jiang, Álvaro Curiel‐García, Yingyun Wang, Bianca J. Lee, Margo Orlen, Kristina Drizyte‐Miller, Marie J. Menard, Julien Dilly, Stephen A. Sastra et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  31. Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion
    Omar L. Gutierrez-Ruiz, Katherine M. Johnson, Eugene W. Krueger, Roseanne E. Nooren, Nicole Cruz-Reyes, Carrie J. Holtz Heppelmann, Tara L. Hogenson, Martín E. Fernández-Zapico, Mark A. McNiven, Gina L. Razidlo · 2023 · Cell Reports
  32. Fibroblast STAT3 Activation Drives Organ-Specific Premetastatic Niche Formation
    Emily L. Lasse Opsahl, Carlos E. Espinoza, Alberto C. Olivei, Jude Ogechukwu Okoye, Hannah R. Watkoske, Megan T. Hoffman, Faith R. Avritt, Ahmed M. Elhossiny, Allison C. Bischoff, Katelyn L. Donahue et al. · 2025 · Cancer Research
  33. Cytokine CCL9 Mediates Oncogenic KRAS-Induced Pancreatic Acinar-to-Ductal Metaplasia by Promoting Reactive Oxygen Species and Metalloproteinases
    Geou‐Yarh Liou, Crystal J. Byrd, Peter Störz, Justin K. Messex · 2024 · International Journal of Molecular Sciences
  34. Cellular collusion: cracking the code of immunosuppression and chemo resistance in PDAC
    Chiara Musiu, Francesca Lupo, Antonio Agostini, Gabriella Lionetto, Michele Bevere, Salvatore Paiella, Carmine Carbone, Vincenzo Corbo, Stefano Ugel, Francesco De Sanctis · 2024 · Frontiers in Immunology
  35. Intratumor Heterogeneity of KRAS Mutation Status in Pancreatic Ductal Adenocarcinoma Is Associated With Smaller Lesions
    Sima S. Nagawkar, Samah Abu-Funni, Einav Simon, Tova Bick, Elad Prinz, Edmond Sabo, Ofer Ben‐Izhak, Dov Hershkovitz · 2015 · Pancreas
  36. Scientific rationale for integrative and personalised strategies for pancreatic ductal adenocarcinoma management
    Peyda Korhan, Robert M. Verkerk, William R. Critchley · 2017 · Integrative Molecular Medicine
  37. Identification of genes and candidate agents associated with pancreatic cancer
    Baosheng Wang, Zhen Liu, Shaolong Sun, Yi Zhao · 2013 · Tumor Biology
  38. A stromal PAI1-tPA axis orchestrates immunosuppression in pancreatic cancer
    Tenzin Ngodup, Brynn E. Elson, Ashley M. Mello, Sean Hannifin, Miranda Liu, Yaqing Zhang, Jiaqi Shi, Yatrik Madhukar Shah, Daniel A. Lawrence, Marina Pasca di Magliano et al. · 2026 · Science Advances
  39. Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer
    Nneka E. Mbah, Damien Sutton, Hanna S. Hong, Rashi Singhal, Rosa Elena Menjivar, Matthew D. Perricone, Heather Giza, Peter Sajjakulnukit, Amy L. Myers, Zeribe C. Nwosu et al. · 2026 · Cancer & Metabolism
  40. Four-class tumor staging for early diagnosis and monitoring of murine pancreatic cancer using magnetic resonance and ultrasound
    Erica Dugnani, Valentina Pasquale, Paolo Marra, Daniela Liberati, Tamara Canu, Laura Perani, Francesco De Sanctis, Stefano Ugel, Francesca Invernizzi, Antonio Citro et al. · 2018 · Carcinogenesis
  41. Kras in Organoids
    Derek K. Cheng, David Arthur Tuveson · 2018 · Cold Spring Harbor Perspectives in Medicine
  42. Oncogenic dependency plays a dominant role in the immune response to cancer
    Jinyu Li, Stephen D’Amico, Varvara Kirillov, Oleksi Petrenko, Nancy C. Reich · 2023 · Proceedings of the National Academy of Sciences
  43. Metabolic Response of Pancreatic Carcinoma Cells under Treatment with Dichloroacetate
    Benedikt Feuerecker, Philipp Biechl, Christian Veltkamp, Dieter Saur, Wolfgang Eisenreich · 2021 · Metabolites
  44. Modulation of PRC1 Promotes Anticancer Effects in Pancreatic Cancer
    Hajin Lee, An-Na Bae, Huiseong Yang, Jae‐Ho Lee, Jong Ho Park · 2024 · Cancers
  45. DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
    Mariana T. Ruckert, R. McKinnon Walsh, Bailey A. Bye, Austin E. Eades, Wei Yan, Filip Bednar, Jiaqi Shi, Emily L. Lasse Opsahl, Marina Pasca di Magliano, Costas Andreas Lyssiotis et al. · 2025 · Scientific Reports
  46. The RAS Signaling Network and Cancer
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  47. Intratumor heterogeneity in KRAS signaling shapes treatment resistance
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  48. KRAS: Structure, function, and development of anticancer drugs
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  49. Quadruplex nucleic acids in KRAS targeted-cancer therapy
    Luigi Emilio Xodo · 2020 · Annual reports in medicinal chemistry
  50. The Endeavours in RAS Inhibition - the Past, Present, and Future
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  51. Oncogenic KRAS engages an RSK1/NF1 complex in pancreatic cancer
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  52. Tropisetron Suppresses Chronic Pancreatitis and Pancreatic Cancer by Blocking Interleukin 33 Expression
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  53. SMURF2 Facilitates GAP17 Isoform 1 Membrane Displacement to Promote Mutant p53–KRAS Oncogenic Synergy
    Paramita Ray, Shirish Shukla, Yaqing Zhang, Katelyn L. Donahue, Derek J. Nancarrow, Srimathi Kasturirangan, Sunita Shankar, Kyle Clifford Cuneo, Dafydd G. Thomas, Shirish M. Gadgeel et al. · 2025 · Molecular Cancer Research
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  58. Risk Factors for Pancreatic Cancer: Underlying Mechanisms and Potential Targets
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  70. Additional file 2 of Inhibition of ERAD synergizes with FTS to eradicate pancreatic cancer cells
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  72. Additional file 1 of Inhibition of ERAD synergizes with FTS to eradicate pancreatic cancer cells
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  73. Additional file 1 of KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells
    Angela Mathison, Romica Kerketta, Thiago M. de Assuncao, Elise N. Leverence, Atefeh Zeighami, Guillermo Urrutia, Stodola, Timothy J., di Magliano, Marina Pasca, Juan Iovanna, Michael T. Zimmermann et al. · 2021 · Figshare
  74. Additional file 3 of KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells
    Angela Mathison, Romica Kerketta, Thiago M. de Assuncao, Elise N. Leverence, Atefeh Zeighami, Urrutia, Guillermo, Stodola, Timothy J., di Magliano, Marina Pasca, Juan Iovanna, Michael T. Zimmermann et al. · 2021 · Figshare
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