Metastatic Pancreatic Cancer Is Dependent on Oncogenic Kras in Mice
Collins, Meredith A., Brisset, Jean-Christophe, Zhang, Yaqing, Bednar, Filip, Pierre, Josette, Heist, Kevin A., Galbán, Craig J., Galbán, Stefanie, di Magliano, Marina Pasca·2012·PLoS ONE
Cited by (179)
Items 101–179 of 179
- Serotonin uptake is required for Rac1 activation in Kras‐induced acinar‐to‐ductal metaplasia in the pancreasEnrica Saponara, Michele Visentin, Francesco Baschieri, Gitta Maria Seleznik, Paola Martinelli, Iréne Esposito, Johanna Buschmann, Rong Chen, Rossella Parrotta, Nathalie Borgeaud et al. · 2018 · The Journal of Pathology
- BRAF-Driven Pancreatic Cancer: Prevalence, Molecular Features, and Therapeutic OpportunitiesAaron Ciner, Yixing Jiang, Petr Frantisek Hausner · 2022 · Molecular Cancer Research
- Persistent ERK/MAPK Activation Promotes Lactotrope Differentiation and Diminishes Tumorigenic PhenotypeAllyson K. Roof, Tammy Trudeau, Crystal Lynna Gomez, Marshall Scott Lucia, Arthur Gutierrez‐Hartmann · 2014 · Molecular Endocrinology
- The Bromodomain Inhibitor, INCB057643, Targets Both Cancer Cells and the Tumor Microenvironment in Two Preclinical Models of Pancreatic CancerAna S. Leal, Phillip Liu, Teresa Krieger-Burke, Bruce Ruggeri, Karen T. Liby · 2020 · Cancers
- Utilizing past and present mouse systems to engineer more relevant pancreatic cancer modelsBrian T. DeCant, Daniel R. Principe, Carmen E. Guerra, Marina Pasca di Magliano, Paul J. Grippo · 2014 · Frontiers in Physiology
- KRas4B-PDE6δ complex stabilization by small molecules obtained by virtual screening affects Ras signaling in pancreatic cancerDiana Casique‐Aguirre, Paola Briseño-Díaz, Ponciano García‐Gutiérrez, Claudia Haydée González-De la Rosa, Reyna Sara Quintero Barceinas, Arturo Rojo‐Domínguez, Irene Vergara, Luis A. Medina, José Correa‐Basurto, Martiniano Bello et al. · 2018 · BMC Cancer
- Functional and mechanistic studies reveal MAGEA3 as a pro-survival factor in pancreatic cancer cellsBiswajit Das, Shantibhusan Senapati · 2019 · Journal of Experimental & Clinical Cancer Research
- In vivo serial selection of human pancreatic cancer cells in orthotopic mouse models produces high metastatic variants irrespective of Kras statusCristina Angela Metildi, Sharmeela Kaushal, Robert M. Hoffman, Michael Bouvet · 2013 · Journal of Surgical Research
- FAK promotes stromal PD-L2 expression associated with poor survival in pancreatic cancerCatherine Davidson, David Taggart, Andrew H. Sims, David W. Lonergan, Marta Canel, Alan Serrels · 2022 · British Journal of Cancer
- Beta 1 integrin signaling mediates pancreatic ductal adenocarcinoma resistance to MEK inhibitionArthur Brannon, Donovan Drouillard, Nina G. Steele, Shadae Schoettle, Ethan V. Abel, Howard C. Crawford, Marina Pasca di Magliano · 2020 · Scientific Reports
- A PET Imaging Strategy for Interrogating Target Engagement and Oncogene Status in Pancreatic CancerKelly E. Henry, Megan M. Dacek, Thomas R. Dilling, Jonathan D. Caen, Ian L. Fox, Michael J. Evans, Jason Stuart Lewis · 2018 · Clinical Cancer Research
- MicroRNAs as biomarkers and perspectives in the therapy of pancreatic cancerTao Xia, Xiaoyi Chen, You-Ni Zhang · 2021 · Molecular and Cellular Biochemistry
- KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cellsAngela Mathison, Romica Kerketta, Thiago M. de Assuncao, Elise N. Leverence, Atefeh Zeighami, Guillermo Urrutia, Timothy J. Stodola, Marina Pasca di Magliano, Juan Iovanna, Michael T. Zimmermann et al. · 2021 · Genome biology
- Extracellular vesicles in Inter-Kingdom communication in gastrointestinal cancer.Yi Chen, Yansong Xu, Huage Zhong, Hao Yuan, Fangfang Liang, Junjie Liu, Weizhong Tang · 2021 · PubMed Central
- RAS specific protease induces irreversible growth arrest via p27 in several KRAS mutant colorectal cancer cell linesCaleb K. Stubbs, Marco Biancucci, Vania Vidimar, K.J.F. Satchell · 2021 · Scientific Reports
- Reshaping the Tumor Microenvironment of KRASG12D Pancreatic Ductal Adenocarcinoma with Combined SOS1 and MEK Inhibition for Improved Immunotherapy ResponseRobert J. Norgard, Pratha Budhani, Sarah A. O’Brien, Youli Xia, Jessica N. Egan, Brianna Flynn, Joshua R. Tagore, Joseph Seco, Gregory W. Peet, Ania Mikucka et al. · 2024 · Cancer Research Communications
- Models of pancreatic ductal adenocarcinomaRayane Dennaoui, Hridaya Shrestha, Kay‐Uwe Wagner · 2021 · Cancer and Metastasis Reviews
- Anoikis-Related Gene Signature for Prognostication of Pancreatic Adenocarcinoma: A Multi-Omics Exploration and Verification StudyJin Zhang, Xuesong Li, Yi Lu, Guowen Wang, Ying Ma · 2023 · Cancers
- A Novel Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth in Mouse Models of GI CancerFoote, Jeremy B., Mattox, Tyler E., Keeton, Adam B., Chen, Xi, Smith, Forrest, Berry, Kristy L., Holmes, Thomas, Wang, Junwei, Huang, Chung-Hui, Ward, Antonio B. et al. · 2023
- Pharmacotherapeutic Management of Pancreatic Ductal Adenocarcinoma: Current and Emerging ConceptsDietrich Alexander Ruess, Kıvanç Görgülü, Sonja M. Wörmann, Hana Algül · 2017 · Drugs & Aging
- Synthetic Vulnerabilities in the KRAS PathwayMarta Román, Elizabeth E. Hwang, Alejandro Sweet-Cordero · 2022 · Cancers
- The KRAS signaling pathway's impact on the characteristics of pancreatic cancer cellsMeiyan Chen, Meiyan Chen, Yuka Fu, Jingyi Zhang · 2023 · Pathology - Research and Practice
- The GSK3 kinase and LZTR1 protein regulate the stability of Ras family proteins and the proliferation of pancreatic cancer cellsChitra Palanivel, Neha Chaudhary, Parthasarathy Seshacharyulu, Jesse L. Cox, Ying Yan, Surinder K. Batra, Michel M. Ouellette · 2022 · Neoplasia
- Murine Models of Pancreatitis Leading to the Development of Pancreatic CancerAna S. Leal, Karen T. Liby · 2018 · Current Protocols in Pharmacology
- Oncogenic signaling pathways in pancreatic ductal adenocarcinomaRahul Agrawal, Kedar Nath Natarajan · 2023 · Advances in cancer research
- Suppression of the KRAS-NRF2 axis shifts arginine into the phosphocreatine energy system in pancreatic cancer cellsEros Di Giorgio, Himanshi Choudhary, Annalisa Ferino, Ylenia Cortolezzis, Emiliano Dalla, Francesca D’Este, Marina Comelli, Valentina Rapozzi, Luigi Emilio Xodo · 2023 · iScience
- Utilizing Salmonella to treat solid malignanciesNancy D. Ebelt, Edwin Ramos Manuel · 2017 · Journal of Surgical Oncology
- Co-dependency between KRAS addiction and ARHGEF2 promotes an adaptive escape from MAPK pathway inhibitionOliver A. Kent, María José Sandí, Robert K. Rottapel · 2017 · Small GTPases
- The occurrence of prion protein in surgically resected pancreatic adenocarcinomaMatteo Bianchini, Maria Anita Giambelluca, Maria Concetta Scavuzzo, Gregorio Di Franco, Simone Guadagni, Matteo Palmeri, Niccolò Furbetta, Desirée Gianardi, Niccola Funel, Luca Emanuele Pollina et al. · 2020 · Pancreatology
- Tumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinomaUrszula N. Wasko, Jingjing Jiang, Álvaro Curiel‐García, Yingyun Wang, Bianca J. Lee, Margo Orlen, Kristina Drizyte‐Miller, Marie J. Menard, Julien Dilly, Stephen A. Sastra et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasionOmar L. Gutierrez-Ruiz, Katherine M. Johnson, Eugene W. Krueger, Roseanne E. Nooren, Nicole Cruz-Reyes, Carrie J. Holtz Heppelmann, Tara L. Hogenson, Martín E. Fernández-Zapico, Mark A. McNiven, Gina L. Razidlo · 2023 · Cell Reports
- Fibroblast STAT3 Activation Drives Organ-Specific Premetastatic Niche FormationEmily L. Lasse Opsahl, Carlos E. Espinoza, Alberto C. Olivei, Jude Ogechukwu Okoye, Hannah R. Watkoske, Megan T. Hoffman, Faith R. Avritt, Ahmed M. Elhossiny, Allison C. Bischoff, Katelyn L. Donahue et al. · 2025 · Cancer Research
- Cytokine CCL9 Mediates Oncogenic KRAS-Induced Pancreatic Acinar-to-Ductal Metaplasia by Promoting Reactive Oxygen Species and MetalloproteinasesGeou‐Yarh Liou, Crystal J. Byrd, Peter Störz, Justin K. Messex · 2024 · International Journal of Molecular Sciences
- Cellular collusion: cracking the code of immunosuppression and chemo resistance in PDACChiara Musiu, Francesca Lupo, Antonio Agostini, Gabriella Lionetto, Michele Bevere, Salvatore Paiella, Carmine Carbone, Vincenzo Corbo, Stefano Ugel, Francesco De Sanctis · 2024 · Frontiers in Immunology
- Intratumor Heterogeneity of KRAS Mutation Status in Pancreatic Ductal Adenocarcinoma Is Associated With Smaller LesionsSima S. Nagawkar, Samah Abu-Funni, Einav Simon, Tova Bick, Elad Prinz, Edmond Sabo, Ofer Ben‐Izhak, Dov Hershkovitz · 2015 · Pancreas
- Scientific rationale for integrative and personalised strategies for pancreatic ductal adenocarcinoma managementPeyda Korhan, Robert M. Verkerk, William R. Critchley · 2017 · Integrative Molecular Medicine
- Identification of genes and candidate agents associated with pancreatic cancerBaosheng Wang, Zhen Liu, Shaolong Sun, Yi Zhao · 2013 · Tumor Biology
- A stromal PAI1-tPA axis orchestrates immunosuppression in pancreatic cancerTenzin Ngodup, Brynn E. Elson, Ashley M. Mello, Sean Hannifin, Miranda Liu, Yaqing Zhang, Jiaqi Shi, Yatrik Madhukar Shah, Daniel A. Lawrence, Marina Pasca di Magliano et al. · 2026 · Science Advances
- Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancerNneka E. Mbah, Damien Sutton, Hanna S. Hong, Rashi Singhal, Rosa Elena Menjivar, Matthew D. Perricone, Heather Giza, Peter Sajjakulnukit, Amy L. Myers, Zeribe C. Nwosu et al. · 2026 · Cancer & Metabolism
- Four-class tumor staging for early diagnosis and monitoring of murine pancreatic cancer using magnetic resonance and ultrasoundErica Dugnani, Valentina Pasquale, Paolo Marra, Daniela Liberati, Tamara Canu, Laura Perani, Francesco De Sanctis, Stefano Ugel, Francesca Invernizzi, Antonio Citro et al. · 2018 · Carcinogenesis
- Kras in OrganoidsDerek K. Cheng, David Arthur Tuveson · 2018 · Cold Spring Harbor Perspectives in Medicine
- Oncogenic dependency plays a dominant role in the immune response to cancerJinyu Li, Stephen D’Amico, Varvara Kirillov, Oleksi Petrenko, Nancy C. Reich · 2023 · Proceedings of the National Academy of Sciences
- Metabolic Response of Pancreatic Carcinoma Cells under Treatment with DichloroacetateBenedikt Feuerecker, Philipp Biechl, Christian Veltkamp, Dieter Saur, Wolfgang Eisenreich · 2021 · Metabolites
- Modulation of PRC1 Promotes Anticancer Effects in Pancreatic CancerHajin Lee, An-Na Bae, Huiseong Yang, Jae‐Ho Lee, Jong Ho Park · 2024 · Cancers
- DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cellsMariana T. Ruckert, R. McKinnon Walsh, Bailey A. Bye, Austin E. Eades, Wei Yan, Filip Bednar, Jiaqi Shi, Emily L. Lasse Opsahl, Marina Pasca di Magliano, Costas Andreas Lyssiotis et al. · 2025 · Scientific Reports
- The RAS Signaling Network and CancerPriya S. Hibshman, Channing J. Der · 2024 · Springer eBooks
- Intratumor heterogeneity in KRAS signaling shapes treatment resistanceOleksi Petrenko, Varvara Kirillov, Stephen D’Amico, Nancy C. Reich · 2024 · iScience
- KRAS: Structure, function, and development of anticancer drugsDolly A. Parasrampuria, Alex Yu, Nahor Haddish‐Berhane · 2020 · Elsevier eBooks
- Quadruplex nucleic acids in KRAS targeted-cancer therapyLuigi Emilio Xodo · 2020 · Annual reports in medicinal chemistry
- The Endeavours in RAS Inhibition - the Past, Present, and FutureJaveena Hussain, Sivapriya Kirubakaran, Srimadhavi Ravi · 2020 · Current Topics in Medicinal Chemistry
- Oncogenic KRAS engages an RSK1/NF1 complex in pancreatic cancerDerek K. Cheng, Tobiloba E. Oni, Youngkyu Park, Jennifer S. Thalappillil, Hsiu-Chi Ting, Brinda Alagesan, Nadia V. Prasad, Keith D. Rivera, Darryl Pappin, Linda Van Aelst et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Tropisetron Suppresses Chronic Pancreatitis and Pancreatic Cancer by Blocking Interleukin 33 ExpressionAn-Na Bae, Mahsa Mortaja, YeePui Yeung, Jiao Huang, Jong Ho Park, Shadmehr Demehri · 2025 · Cancers
- SMURF2 Facilitates GAP17 Isoform 1 Membrane Displacement to Promote Mutant p53–KRAS Oncogenic SynergyParamita Ray, Shirish Shukla, Yaqing Zhang, Katelyn L. Donahue, Derek J. Nancarrow, Srimathi Kasturirangan, Sunita Shankar, Kyle Clifford Cuneo, Dafydd G. Thomas, Shirish M. Gadgeel et al. · 2025 · Molecular Cancer Research
- Road Map to Defeat Pancreatic CancerLesley Paige Ferguson, David A. Tuveson · 2025 · Annual Review of Cancer Biology
- STAT3 sustains tumorigenicity following mutant KRAS ablationStephen D’Amico, Varvara Kirillov, Jingxuan Liu, Zhijuan Qiu, Xinyuan Lei, Hong Qin, Brian S. Sheridan, Nancy C. Reich · 2025 · EMBO Reports
- PLK1 and its role in the evolving landscape of KRAS-mutated colorectal cancerHarry Myles Harvey, Eric Xueyu Chen · 2024 · Journal of Gastrointestinal Oncology
- Hypoxia Impairs CD8+ T Cell Fitness and Is Associated with a Dysfunctional CD8+ T Cell State in Pancreatic CancerAshley M. Mello, Marina Pasca di Magliano, K P Lee · 2026 · Cancers
- Risk Factors for Pancreatic Cancer: Underlying Mechanisms and Potential Targets2015 · Frontiers research topics
- A shifting adversary: control of pancreatic cancer transcriptomic subtypesCharles J. David · 2022 · Journal of Cancer Metastasis and Treatment
- Emerging Technologies for the Diagnosis and Treatment of Pancreatic CancerMagdalena Swierczewska, С. В. Козлов, Pavan P. Adiseshaiah · 2018 · Elsevier eBooks
- RAS Genes and CancerTikvah K. Hayes, Jeran K. Stratford, Andrea Wang‐Gillam, Channing J. Der · 2014 · Springer eBooks
- Characterizing the Metabolomic Effects of Pancreatic CancerOliver F. Bathe · 2014 · Elsevier eBooks
- Cross Talk Between Snail and Mutant K-Ras Contributes to Pancreatic Cancer ProgressionChristina R. Chow, Kazumi Ebine, Holly Z. Hattaway, Krishan Kumar, Hidayatullah G. Munshi · 2016 · Elsevier eBooks
- Oncogenic KRAS and the Inflammatory Micro-Environment in Pancreatic CancerHui-Hua Chang, Andrea Schmidt, Guido Eibl · 2016 · Elsevier eBooks
- Investigação das quinases Aurora A e Aurora B na tumorigenicidade mediada pelo oncogene KRASEdmilson Ozorio dos Santos · 2017 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- Development of novel gene delivery system for cancer therapyChengbin Yang · 2018 · DR-NTU (Nanyang Technological University)
- Regulation of the kRAS Promoter in Pancreatic Cancer by Proteins and Small MoleculesHarshul Batra · 2017 · ProQuest Demo Repository
- Investigating Molecular Mechanisms of Drug Resistance in a 3D Cell Culture Model of Pancreatic CancerArthur Brannon · 2017 · Deep Blue (University of Michigan)
- Defining Roles of Metabolic Reprogramming in Pancreatic Tumorigenesis and Tumor MaintenanceBarbara Scott Nelson · 2020 · Deep Blue (University of Michigan)
- Additional file 2 of Inhibition of ERAD synergizes with FTS to eradicate pancreatic cancer cellsRong Du, Delaney K. Sullivan, Nancy G. Azizian, Liu, Yuanhui, Li, Yulin · 2021 · Figshare
- In vivo cancer modeling using mouse modelsPrafulla Chandra Tiwari, Manju Jyoti Chaudhary, Rishi Pal, Rajendra Nath · 2025 · Methods in cell biology
- Additional file 1 of Inhibition of ERAD synergizes with FTS to eradicate pancreatic cancer cellsDu, Rong, Delaney K. Sullivan, Nancy G. Azizian, Liu, Yuanhui, Yulin Li · 2021 · Figshare
- Additional file 1 of KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cellsAngela Mathison, Romica Kerketta, Thiago M. de Assuncao, Elise N. Leverence, Atefeh Zeighami, Guillermo Urrutia, Stodola, Timothy J., di Magliano, Marina Pasca, Juan Iovanna, Michael T. Zimmermann et al. · 2021 · Figshare
- Additional file 3 of KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cellsAngela Mathison, Romica Kerketta, Thiago M. de Assuncao, Elise N. Leverence, Atefeh Zeighami, Urrutia, Guillermo, Stodola, Timothy J., di Magliano, Marina Pasca, Juan Iovanna, Michael T. Zimmermann et al. · 2021 · Figshare
- Effet du TGFβ produit par le microenvironnement sur les tumeurs du pancréas exocrineVictoire Cardot‐Ruffino · 2019 · theses.fr (ABES)
- Extracellular vesicles in cancer therapyAkshay Kumar Jha, Sanchit Arora, Charan Singh, Dinesh Kumar, Ashish Kumar Agrawal · 2026 · Elsevier eBooks
- KRAS and Beyond: Emerging Targeted and Molecularly Stratified Strategies in Pancreatic Ductal AdenocarcinomaAlicia Yioli Lefas, Hazel Lote, Ian Chau · 2026 · Precision Oncology
- The Long, Remarkable History of KRAS and Pancreatic Cancer: From Gene Discovery to Successful Therapeutic TargetingRalph H. Hruban, Scott E. Kern · 2026 · Modern Pathology
- Mouse Models of RAS-Induced Tumors and Developmental DisordersCarmen E. Guerra, Mariano Barbacid · 2014 · Springer eBooks