The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A Consensus Method for the Prediction of ‘Aggregation-Prone’ Peptides in Globular Proteins
Open accessAbstract
The purpose of this work was to construct a consensus prediction algorithm of 'aggregation-prone' peptides in globular proteins, combining existing tools. This allows comparison of the different algorithms and the production of more objective and accurate results. Eleven (11) individual methods are combined and produce AMYLPRED2, a publicly, freely available web tool to academic users (http://biophysics.biol.uoa.gr/AMYLPRED2), for the consensus prediction of amyloidogenic determinants/'aggregation-prone' peptides in proteins, from sequence alone. The performance of AMYLPRED2 indicates that it functions better than individual aggregation-prediction algorithms, as perhaps expected. AMYLPRED2 is a useful tool for identifying amyloid-forming regions in proteins that are associated with several conformational diseases, called amyloidoses, such as Altzheimer's, Parkinson's, prion diseases and type II diabetes. It may also be useful for understanding the properties of protein folding and misfolding and for helping to the control of protein aggregation/solubility in biotechnology (recombinant proteins forming bacterial inclusion bodies) and biotherapeutics (monoclonal antibodies and biopharmaceutical proteins).
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Kabsch, W., & Sander, C. (1983) · Biopolymers · doi:10.1002/bip.360221211 · Cited by 15,320
Rationalization of the effects of mutations on peptide andprotein aggregation rates
Chiti, F., Stefani, M., Taddei, N., Ramponi, G., & Dobson, C. M. (2003) · Nature · doi:10.1038/nature01891 · Cited by 1,072
Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies
Wang, X., Das, T. K., Singh, S. K., & Kumar, S. (2009) · mAbs · doi:10.4161/mabs.1.3.8035 · Cited by 198
Kumar, S., Singh, S. K., Wang, X., Rup, B., & Gill, D. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0414-9 · Cited by 85
Cited by
Protein recovery from inclusion bodies of Escherichia coli using mild solubilization process
Singh, A., Upadhyay, V., Upadhyay, A. K., Singh, S. M., & Panda, A. K. (2015) · Microbial Cell Factories · doi:10.1186/s12934-015-0222-8 · Cited by 444
Role of Hydrophobins in Aspergillus fumigatus
Valsecchi, I., Dupres, V., Stephen-Victor, E., Guijarro, J., Gibbons, J., Beau, R., Bayry, J., Coppee, J.-Y., Lafont, F., Latgé, J.-P., et al. (2017) · Journal of Fungi · doi:10.3390/jof4010002 · Cited by 123
Besingi, R. N., Wenderska, I. B., Senadheera, D. B., Cvitkovitch, D. G., Long, J. R., Wen, Z. T., & Brady, L. J. (2017) · Microbiology · doi:10.1099/mic.0.000443 · Cited by 99
Production and characterization of amaranth amyloid fibrils from food protein waste
Mykolenko, S., Soon, W. L., & Mezzenga, R. (2024) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2023.109604 · Cited by 60
Assembly and disassembly of Aspergillus fumigatus conidial rodlets
Valsecchi, I., Lai, J. I., Stephen-Victor, E., Pillé, A., Beaussart, A., Lo, V., Pham, C. L. L., Aimanianda, V., Kwan, A. H., Duchateau, M., et al. (2019) · The Cell Surface · doi:10.1016/j.tcsw.2019.100023 · Cited by 46
Metadata
- Authors
- Tsolis, A. C., Papandreou, N. C., Iconomidou, V. A., & Hamodrakas, S. J.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-01-10
- Volume
- 8
- Issue
- 1
- Pages
- e54175
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2033853317
- Cited by
- 324
- References
- 4
- FWCI
- 9.28
- Type
- journal article
- Language
- en
- Open access
- gold
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- Tsolis, A. C., Papandreou, N. C., Iconomidou, V. A., & Hamodrakas, S. J. (2013). A Consensus Method for the Prediction of ‘Aggregation-Prone’ Peptides in Globular Proteins. PLoS ONE. https://doi.org/10.1371/journal.pone.0054175
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