Epidemiology of candidemia in Latin America: a laboratory-based survey
Open accessAbstract
BACKGROUND: The epidemiology of candidemia varies depending on the geographic region. Little is known about the epidemiology of candidemia in Latin America. METHODS: We conducted a 24-month laboratory-based survey of candidemia in 20 centers of seven Latin American countries. Incidence rates were calculated and the epidemiology of candidemia was characterized. RESULTS: Among 672 episodes of candidemia, 297 (44.2%) occurred in children (23.7% younger than 1 year), 36.2% in adults between 19 and 60 years old and 19.6% in elderly patients. The overall incidence was 1.18 cases per 1,000 admissions, and varied across countries, with the highest incidence in Colombia and the lowest in Chile. Candida albicans (37.6%), C. parapsilosis (26.5%) and C. tropicalis (17.6%) were the leading agents, with great variability in species distribution in the different countries. Most isolates were highly susceptible to fluconazole, voriconazole, amphotericin B and anidulafungin. Fluconazole was the most frequent agent used as primary treatment (65.8%), and the overall 30-day survival was 59.3%. CONCLUSIONS: This first large epidemiologic study of candidemia in Latin America showed a high incidence of candidemia, high percentage of children, typical species distribution, with C. albicans, C. parapsilosis and C. tropicalis accounting for the majority of episodes, and low resistance rates.
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The incidence of hospitalizations with invasive candidiasis was 90/100,000, comparable to another hospital laboratory-based study in Latin America, which found an incidence of 118/100,000 hospitalizations across all countries.
“we found the incidence of hospitalizations with IC to be 90/100 000 hospitalizations, comparable to another hospital laboratory-based study in Latin America, which found an incidence of 118/100 000 hospitalizations across all countries [19].”
From Invasive candidiasis species distribution and trends, United States, 2009-2017 (2021) · cites this paper as [19]
In Latin America, the most common Candida species were C. albicans (37.6%), C. parapsilosis (26.5%), and C. tropicalis (17.6%), whereas C. glabrata was low.
“The most common Candida species in this study were C. albicans (37.6%), C. parapsilosis (26.5%), and C. tropicalis (17.6%), whereas the distribution of C. glabrata was low.7”
Previous studies indicate regional differences in the distribution of Candida species.
“These previous studies indicate regional differences in the distribution of Candida spp.”
In India and Latin America, Candida tropicalis is one of the most frequently encountered species.
“In India and Latin America, it has been reported that C. tropicalis is one of the most frequently encountered species.7,23,24”
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References 43 · Cited by 374
Research works printed but not linked: 1
- [24]Lopez ML, Tiraboschi IN, Schijman M, Bianchi M, Guelfand L, et al (2012) [Fungemia in hospitals of the City of Buenos Aires, Argentina]. Rev Iberoam Micol 29: 144– 149. 22120499
- Authors
- Nucci, M., Queiroz-Telles, F., Alvarado-Matute, T., Tiraboschi, I. N., Cortes, J., Zurita, J., Guzman-Blanco, M., Santolaya, M. E., Thompson, L., Sifuentes-Osornio, J., Echevarria, J. I., Colombo, A. L., & on behalf of the Latin American Invasive Mycosis Network
- Affiliations
- Hospital de Clínicas "José de San Martín" (AR)
- Pontificia Universidad Católica del Ecuador (EC)
- Universidad del Desarrollo (CL)
- Universidad Peruana Cayetano Heredia (PE)
- Universidade Federal de São Paulo (BR)
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-03-19
- Volume
- 8
- Issue
- 3
- Pages
- e59373
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3601956
- OpenAlex
- W2059302109
- Cited by
- 374
- References
- 43
- Citations by year
- 2026: 15 · 2025: 14 · 2024: 21 · 2023: 27 · 2022: 23 · 2021: 22 · 2020: 35 · 2019: 36 · 2018: 33 · 2017: 35 · 2016: 38 · 2015: 32 · 2014: 34 · 2013: 9
- FWCI
- 27.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Repositorio Institucional (Pontificia Universidad Javeriana) (submittedVersion, cc-by-nc)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Greater South Information System
- Funders
- Pfizer
- Universidad de Chile
- Universidade Federal do Rio de Janeiro
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- candidemia, Latin America, candidemia incidence, Candida albicans, Candida parapsilosis, Candida tropicalis, antifungal susceptibility, fluconazole, voriconazole, amphotericin B, anidulafungin, 30-day survival, species distribution
- MeSH terms
- Adolescent, Adult, Aged, Candida, Child, Child, Preschool, Humans, Infant, Latin America, Middle Aged, Prospective Studies, Species Specificity, Fluconazole, Incidence, Statistics, Nonparametric, Candidemia, Epidemiological Monitoring
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