The Geometry of Locomotive Behavioral States in C. elegans
Open accessAbstract
We develop a new hidden Markov model-based method to analyze C elegans locomotive behavior and use this method to quantitatively characterize behavioral states. In agreement with previous work, we find states corresponding to roaming, dwelling, and quiescence. However, we also find evidence for a continuum of intermediate states. We suggest that roaming, dwelling, and quiescence may best be thought of as extremes which, mixed in any proportion, define the locomotive repertoire of C elegans foraging and feeding behavior.
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Other studies have shown that the complexity and dimensionality of behaviors can be studied by embedding trajectories in a low-dimensional behavioral space.
“Other studies [19–22] have shown that the complexity and dimensionality of behaviors can be studied by embedding such trajectories in a low-dimensional “behavioral space.””
From The Behavioral Space of Zebrafish Locomotion and Its Neural Network Analog (2015) · cites this paper as [21]
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References 30 · Cited by 85
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- Authors
- Gallagher, T., Bjorness, T., Greene, R., You, Y.-J., & Avery, L.
- Affiliations
- Virginia Commonwealth University (US)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Avery, Leon
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-03-28
- Volume
- 8
- Issue
- 3
- Pages
- e59865
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3610905
- OpenAlex
- W1984295865
- Cited by
- 85
- References
- 30
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 10 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 7 · 2017: 6 · 2016: 10 · 2015: 10 · 2014: 7 · 2013: 5
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- VCU Scholars Compass (Virginia Commonwealth University) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health (OD010440, P40OD010440)
- National Institute of Mental Health (R01MH067777, MH067777)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK083593)
- Office of Research Infrastructure Programs, National Institutes of Health (P40OD010440, OD010440)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- Caenorhabditis elegans, locomotion, behavioral state, hidden Markov models, roaming, dwelling, quiescence, intermediate state, foraging behavior, feeding behavior
- MeSH terms
- Algorithms, Animals, Aztreonam, Behavior, Animal, Feeding Behavior, Genotype, Locomotion, Markov Chains, Models, Biological, Probability, Caenorhabditis elegans, Principal Component Analysis
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