Characterization of Novel CSF Tau and ptau Biomarkers for Alzheimer’s Disease

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Items 101–200 of 209

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  4. Tau-Targeted Therapeutic Strategies: Mechanistic Targets, Clinical Pipelines, and Analysis of Failures
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  5. Biomarkers in Alzheimer’s disease
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  7. Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry
    Richard Y.‐C. Huang, Roxana E. Iacob, Sethu Sankaranarayanan, Ling Yang, Michael K. Ahlijanian, Li Tao, Adrienne A. Tymiak, Guodong Chen · 2017 · Journal of the American Society for Mass Spectrometry
  8. The interplay between aging‐associated loss of protein homeostasis and extracellular vesicles in neurodegeneration
    Francesc Xavier Guix · 2019 · Journal of Neuroscience Research
  9. Proteomic studies of cerebrospinal fluid biomarkers of Alzheimer’s disease: an update
    Erik Portelius, Gunnar Brinkmalm, Josef Pannee, Henrik Zetterberg, Kaj Blennow, Rahil Dahlén, Ann Brinkmalm, Johan Gobom · 2017 · Expert Review of Proteomics
  10. Distinct Neurotoxic Effects of Extracellular Tau Species in Primary Neuronal-Glial Cultures
    Katryna Pampuščenko, Ramunė Morkūnienė, Lukas Krasauskas, Vytautas Smirnovas, Taisuke Tomita, Vilmantė Borutaitė · 2020 · Molecular Neurobiology
  11. Domain-specific Quantification of Prion Protein in Cerebrospinal Fluid by Targeted Mass Spectrometry
    Eric Vallabh Minikel, Eric W. Kuhn, Alexandra R. Cocco, Sonia M. Vallabh, Christina R. Hartigan, Andrew G. Reidenbach, Jiri Safar, Gregory J. Raymond, Michael D. McCarthy, Rhonda O’Keefe et al. · 2019 · Molecular & Cellular Proteomics
  12. Tau Monoclonal Antibody Generation Based on Humanized Yeast Models
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    Zhi Ruan, Tsuneya Ikezu · 2019 · Advances in experimental medicine and biology
  15. Neurogranin Levels in Cerebrospinal Fluid
    Henrik Zetterberg, Kaj Blennow · 2015 · JAMA Neurology
  16. Influence of cognitive impairment and race on plasma p‐Tau 217 in two diverse cohorts
    Ashima Nayyar, Mei‐Ling Li, Victor Sotelo, Guibin J Su, Isabelle Hwang, Milota Kaluzová, Mini Jomartin, Michelle Migut, Hilary Grosso Jasutkar, Karlyndsay Sitterley et al. · 2025 · Alzheimer s & Dementia
  17. Fluid‐based proteomics targeted on pathophysiological processes and pathologies in neurodegenerative diseases
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  18. Development and Validation of a High Sensitivity Assay for Measuring p217 + tau in Cerebrospinal Fluid
    Gallen Triana‐Baltzer, Kristof Van Kolen, Clara Theunis, Setareh Moughadam, Randy Slemmon, Marc H. Mercken, Wendy R. Galpern, Hong Fan Sun, Hartmuth Christian Kolb · 2020 · Journal of Alzheimer s Disease
  19. The Proteoform Landscape of Tau from the Human Brain
    Tian Xu, Taojunfeng Su, Benjamin J. Des Soye, Soumya Kandi, Che‐Fan Huang, John T. Wilkins, Rudolph J. Castellani, Jared O. Kafader, Steven M. Patrie, Robert J. Vassar et al. · 2025 · Journal of Proteome Research
  20. Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease
    Mohammad Arastoo, Richard A. Lofthouse, Lewis K. Penny, Charles R. Harrington, Andy Porter, Claude M. Wischik, Soumya Palliyil · 2020 · International Journal of Molecular Sciences
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  25. A Phase 1 Single-Ascending-Dose Trial in Healthy Volunteers to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Intravenous PNT001, a Novel Mid-domain Tau Antibody Targeting cis-pT231 Tau
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  26. Alzheimer's Disease Biomarker Analysis Using Targeted Mass Spectrometry
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  27. Which neuroimaging and fluid biomarkers method is better in theranostic of Alzheimer’s disease? An umbrella review
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  28. Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro
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  29. Expanding the Repertoire of Biomarkers for Alzheimer’s Disease: Targeted and Non-targeted Approaches
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  32. Two novel blood-based biomarker candidates measuring degradation of tau are associated with dementia: A prospective study
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  33. Chronic Neuroinflammation Induced by Lipopolysaccharide Injection into the Third Ventricle Induces Behavioral Changes
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  34. Cerebrospinal fluid N-224 tau helps discriminate Alzheimer’s disease from subjective cognitive decline and other dementias
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    Monika Arbaciauskaite, Lei Yu, Yong Ku Cho · 2021 · Antibody Therapeutics
  36. A Quantitative LC-MS/MS Method for Distinguishing the Tau Protein Forms Phosphorylated and Nonphosphorylated at Serine-396
    Anne‐Marie Jacobsen, Nico C. van de Merbel, Dorte Kornerup Ditlevsen, Ketil Tvermosegaard, Frank Schalk, Wietske Lambert, Christoffer Bundgaard, Jan T. Pedersen, Nina Rosenqvist · 2023 · Journal of the American Society for Mass Spectrometry
  37. Preclinical characterization and IND‐enabling safety studies for PNT001, an antibody that recognizes cis‐pT231 tau
    Kelly Foster, Matteo Manca, Kim F. McClure, Pyry P. Koivula, John Q. Trojanowski, Daniel Havas, Sarah E. Chancellor, Lee E. Goldstein, Kurt R. Brunden, Allison Kraus et al. · 2023 · Alzheimer s & Dementia
  38. Use of the tau protein-to-peptide ratio in CSF to improve diagnostic classification of Alzheimer’s disease
    Karl Hansson, Rahil Dahlén, Oskar Hansson, Elin Pernevik, Ross W. Paterson, Jonathan M. Schott, Nadia K. Magdalinou, Henrik Zetterberg, Kaj Blennow, Johan Gobom · 2019 · Clinical mass spectrometry
  39. ELISA Evaluation of Tau Accumulation in the Brains of Patients with Alzheimer Disease
    Mitsuru Shinohara, Junko Hirokawa, Akemi Shimodaira, Yoshitaka Tashiro, Kaoru Suzuki, Ghupurjan Gheni, Akio Fukumori, Tomoyasu Matsubara, Maho Morishima, Yuko Saito et al. · 2021 · Journal of Neuropathology & Experimental Neurology
  40. Longitudinal evaluation of proton magnetic resonance spectroscopy metabolites as biomarkers in Huntington’s disease
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  41. Tauopathy-Associated Tau Fragment Ending at Amino Acid 224 Is Generated by Calpain-2 Cleavage
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  42. Mass Spectrometry-Based Quantification of Tau in Human Cerebrospinal Fluid Using a Complementary Tryptic Peptide Standard
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  43. NT1-Tau Is Increased in CSF and Plasma of CJD Patients, and Correlates with Disease Progression
    Mengel, David, Mok, Tze How, Nihat, Akin, Liu, Wen, Rissman, Robert A., Galasko, Douglas, Zetterberg, Henrik, Mead, Simon, Collinge, John, Walsh, Dominic M. · 2021 · Cells
  44. Tanycytic degeneration impairs tau clearance and contributes to Alzheimer’s disease pathology
    Florent Sauvé, Ricardo Gomez-Martínez, Yvon Mbouamboua, Gaëtan Ternier, Sreekala S. Nampoothiri, Elian Dupré, Lolie Garcia, Marie Couralet, Julie Dewisme, Thibaud Lebouvier et al. · 2026 · Cell Press Blue
  45. Tau Diagnostics and Clinical Studies
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  50. High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease
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  53. Semorinemab Pharmacokinetics and The Effect on Plasma Total Tau Pharmacodynamics in Clinical Studies
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  56. Investigating the Impact of Sorghum on Tau Protein Phosphorylation and Mitochondrial Dysfunction Modulation in Alzheimer’s Disease: An In Vitro Study
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