Characterization of Novel CSF Tau and ptau Biomarkers for Alzheimer’s Disease
Meredith Jr., Jere E., Sankaranarayanan, Sethu, Guss, Valerie, Lanzetti, Anthony J., Berisha, Flora, Neely, Robert J., Slemmon, J. Randall, Portelius, Erik, Zetterberg, Henrik, Blennow, Kaj, Soares, Holly, Ahlijanian, Michael, Albright, Charles F.·2013·PLoS ONE
Cited by (209)
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- Distinct Neurotoxic Effects of Extracellular Tau Species in Primary Neuronal-Glial CulturesKatryna Pampuščenko, Ramunė Morkūnienė, Lukas Krasauskas, Vytautas Smirnovas, Taisuke Tomita, Vilmantė Borutaitė · 2020 · Molecular Neurobiology
- Domain-specific Quantification of Prion Protein in Cerebrospinal Fluid by Targeted Mass SpectrometryEric Vallabh Minikel, Eric W. Kuhn, Alexandra R. Cocco, Sonia M. Vallabh, Christina R. Hartigan, Andrew G. Reidenbach, Jiri Safar, Gregory J. Raymond, Michael D. McCarthy, Rhonda O’Keefe et al. · 2019 · Molecular & Cellular Proteomics
- Tau Monoclonal Antibody Generation Based on Humanized Yeast ModelsJoëlle Rosseels, Jeff Van den Brande, Marie Violet, Dirk Jacobs, Pierre Grognet, Juan M. Lopez, Isabelle Huvent, Marina Caldara, Erwin Swinnen, Anthony Papegaey et al. · 2014 · Journal of Biological Chemistry
- CSF in Alzheimer's DiseaseHenrik Zetterberg, Ronald Lautner, Tobias Borgh Skillbäck, Christoffer Rosén, Pashtun Shahim, Niklas Mattsson, Kaj Blennow · 2014 · Advances in clinical chemistry
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- Development and Validation of a High Sensitivity Assay for Measuring p217 + tau in Cerebrospinal FluidGallen Triana‐Baltzer, Kristof Van Kolen, Clara Theunis, Setareh Moughadam, Randy Slemmon, Marc H. Mercken, Wendy R. Galpern, Hong Fan Sun, Hartmuth Christian Kolb · 2020 · Journal of Alzheimer s Disease
- The Proteoform Landscape of Tau from the Human BrainTian Xu, Taojunfeng Su, Benjamin J. Des Soye, Soumya Kandi, Che‐Fan Huang, John T. Wilkins, Rudolph J. Castellani, Jared O. Kafader, Steven M. Patrie, Robert J. Vassar et al. · 2025 · Journal of Proteome Research
- Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s DiseaseMohammad Arastoo, Richard A. Lofthouse, Lewis K. Penny, Charles R. Harrington, Andy Porter, Claude M. Wischik, Soumya Palliyil · 2020 · International Journal of Molecular Sciences
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- A Phase 1 Single-Ascending-Dose Trial in Healthy Volunteers to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Intravenous PNT001, a Novel Mid-domain Tau Antibody Targeting cis-pT231 TauWendy Luca, Kelly Foster, K. McClure, Michael K. Ahlijanian, Martin R. Jefson · 2024 · The Journal of Prevention of Alzheimer s Disease
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- Which neuroimaging and fluid biomarkers method is better in theranostic of Alzheimer’s disease? An umbrella reviewHossein Mohammadi, Armin Ariaei, Zahra Ghobadi, Enam Alhagh Charkhat Gorgich, Auob Rustamzadeh · 2024 · IBRO Neuroscience Reports
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- Expanding the Repertoire of Biomarkers for Alzheimer’s Disease: Targeted and Non-targeted ApproachesDouglas R Galasko · 2015 · Frontiers in Neurology
- Neuronal injury biomarkers for assessment of the individual cognitive reserve in clinically suspected Alzheimer's diseaseLeonie Beyer, Jonas Schnabel, Philipp Maximilian Kazmierczak, Michael Ewers, Sonja Schönecker, Catharina Prix, Johanna Meyer-Wilmes, Marcus Unterrainer, Cihan Catak, Oliver Michael Pogarell et al. · 2019 · NeuroImage Clinical
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- Chronic Neuroinflammation Induced by Lipopolysaccharide Injection into the Third Ventricle Induces Behavioral ChangesShufang Na, Xuejiao Duan, Rongyan Wang, Yanjie Fan, Ke Xue, Shuwei Tian, Zheqiong Yang, Ke Li, Jiang Yue · 2021 · Journal of Molecular Neuroscience
- Cerebrospinal fluid N-224 tau helps discriminate Alzheimer’s disease from subjective cognitive decline and other dementiasClaudia Cicognola, Oskar Hansson, Philip Scheltens, Hlin Kvartsberg, Henrik Zetterberg, Charlotte Elisabeth Teunissen, Kaj Blennow · 2021 · Alzheimer s Research & Therapy
- High-specificity antibodies and detection methods for quantifying phosphorylated tau from clinical samplesMonika Arbaciauskaite, Lei Yu, Yong Ku Cho · 2021 · Antibody Therapeutics
- A Quantitative LC-MS/MS Method for Distinguishing the Tau Protein Forms Phosphorylated and Nonphosphorylated at Serine-396Anne‐Marie Jacobsen, Nico C. van de Merbel, Dorte Kornerup Ditlevsen, Ketil Tvermosegaard, Frank Schalk, Wietske Lambert, Christoffer Bundgaard, Jan T. Pedersen, Nina Rosenqvist · 2023 · Journal of the American Society for Mass Spectrometry
- Preclinical characterization and IND‐enabling safety studies for PNT001, an antibody that recognizes cis‐pT231 tauKelly Foster, Matteo Manca, Kim F. McClure, Pyry P. Koivula, John Q. Trojanowski, Daniel Havas, Sarah E. Chancellor, Lee E. Goldstein, Kurt R. Brunden, Allison Kraus et al. · 2023 · Alzheimer s & Dementia
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- ELISA Evaluation of Tau Accumulation in the Brains of Patients with Alzheimer DiseaseMitsuru Shinohara, Junko Hirokawa, Akemi Shimodaira, Yoshitaka Tashiro, Kaoru Suzuki, Ghupurjan Gheni, Akio Fukumori, Tomoyasu Matsubara, Maho Morishima, Yuko Saito et al. · 2021 · Journal of Neuropathology & Experimental Neurology
- Longitudinal evaluation of proton magnetic resonance spectroscopy metabolites as biomarkers in Huntington’s diseaseAlexander J. Lowe, Filipe Brogueira Rodrigues, Marzena Arridge, Enrico De Vita, Eileanoir B. Johnson, Rachael I. Scahill, Lauren M. Byrne, Rosanna Tortelli, Amanda Heslegrave, Henrik Zetterberg et al. · 2022 · Brain Communications
- Tauopathy-Associated Tau Fragment Ending at Amino Acid 224 Is Generated by Calpain-2 CleavageClaudia Cicognola, Tuğçe Munise Şatır, Gunnar Brinkmalm, Irena Matečko‐Burmann, Lotta Agholme, Petra Bergström, Bruno Becker, Henrik Zetterberg, Kaj Blennow, Kina Höglund · 2020 · Journal of Alzheimer s Disease
- Mass Spectrometry-Based Quantification of Tau in Human Cerebrospinal Fluid Using a Complementary Tryptic Peptide StandardMaotian Zhou, Duc Minh Duong, Erik C. B. Johnson, Jingting Dai, James J. Lah, Allan I. Levey, Nicholas T. Seyfried · 2019 · Journal of Proteome Research
- NT1-Tau Is Increased in CSF and Plasma of CJD Patients, and Correlates with Disease ProgressionMengel, David, Mok, Tze How, Nihat, Akin, Liu, Wen, Rissman, Robert A., Galasko, Douglas, Zetterberg, Henrik, Mead, Simon, Collinge, John, Walsh, Dominic M. · 2021 · Cells
- Tanycytic degeneration impairs tau clearance and contributes to Alzheimer’s disease pathologyFlorent Sauvé, Ricardo Gomez-Martínez, Yvon Mbouamboua, Gaëtan Ternier, Sreekala S. Nampoothiri, Elian Dupré, Lolie Garcia, Marie Couralet, Julie Dewisme, Thibaud Lebouvier et al. · 2026 · Cell Press Blue
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- Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer’s disease: implications for biomarker development and therapeutic targetingLiara Rizzi, Lea T. Grinberg · 2024 · Acta Neuropathologica Communications
- Tauomics and Kinetics in Human Neurons and Biological FluidsHenrik Zetterberg · 2018 · Neuron
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- High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s diseaseMohammad Arastoo, Lewis K. Penny, Richard A. Lofthouse, Aya Abdallah, Anna Abrahamsson, Pietro Marini, Valeria Melis, Gernot Riedel, Charles R. Harrington, Claude M. Wischik et al. · 2024 · Alzheimer s Research & Therapy
- Tau Protein as a Biological Fluid Biomarker in Neurodegenerative DementiasFranc Llorens, Anna Villar‐Piqué, Niccolò Candelise, Isidró Ferrer, Inga Zerr · 2019 · IntechOpen eBooks
- The Mechanism of Two Benzaldehydes from Aspergillus terreus C23-3 Improve Neuroinflammatory and Neuronal Damage to Delay the Progression of Alzheimer’s DiseaseMinqi Chen, Jinyue Liang, Yi Liu, Yayue Liu, Chunxia Zhou, Pengzhi Hong, Yi Zhang, Zhong‐Ji Qian · 2023 · International Journal of Molecular Sciences
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- A Sandwich-Type Impedimetric Immunosensor for the Detection of Tau-441 BiomarkerKhouloud Djebbi, Yang Xiang, Biao Shi, Lyes Douadji, Xiaohan Chen, Jing Liu, Chaker Tlili, Deqiang Wang · 2025 · Bioengineering
- Evaluation of the biodistribution and preliminary safety profile of a novel brain-targeted manganese dioxide-based nanotheranostic system for Alzheimer’s diseaseLily Yi Li, Elliya Park, Chunsheng He, Azhar Zahoor Abbasi, Jeffrey Theodore Henderson, Paul E. Fraser, Jack Uetrecht, Andrew Michael Rauth, Xiao Yu Wu · 2024 · Nanotoxicology
- hiPSC-neurons recapitulate the subtype-specific cell intrinsic nature of susceptibility to neurodegenerative disease-relevant aggregationIan W. Weidling, Christina N Preiss, Sarah E. Chancellor, Gyan Prakash Srivastava, Lauren Gibilisco, Gen Lin, Melanie S. Brennan, Janice Y. Lee, Lindsay M. Roth, Olga Morozova et al. · 2025 · Acta Neuropathologica Communications
- Modifiable risk factors promoting neurodegeneration is associated with two novel brain degradation markers measured in serumJesper Skov Neergaard, Katrine Dragsbæk, Claus Christiansen, Henning Bay Nielsen, Christopher Thomas Workman, Susanne Brix, Kim Henriksen, M.A. Karsdal · 2017 · Neurochemistry International
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- Metabolomics in the Study of Alzheimer's DiseaseClara Ibáñez, Alberto Valdés, Virginia García‐Cañas, Carolina Simó · 2014 · Comprehensive analytical chemistry
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