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Cited by 67Diabetes and associated disordersDiabetes Management and ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

Incidence of and Mortality from Type I Diabetes in Taiwan From 1999 through 2010: A Nationwide Cohort Study

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Lin, Wei-Hung, Wang, Ming-Cheng, Wang, Wei-Ming, Yang, Deng-Chi, Lam, Chen-Fuh, Roan, Jun-Neng, Li, Chung-Yi·2014·PLoS ONE
DOI 10.1371/journal.pone.0086172PMC PMC3899133
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Abstract

OBJECTIVE: To evaluate the secular trend in incidence of and mortality from Type 1 diabetes mellitus (T1DM) in Taiwan, 1999-2010. METHODS: All 7,225 incident cases of T1DM were retrospectively retrieved from Taiwan's National Health Insurance Research Database from 1999 to 2010. Trend of bi-annual age- and sex-specific incidence rates of T1DM was calculated and tested with Poisson regression model. Standardized mortality ratios (SMRs) were calculated, using age-, sex-, and calendar years-specific mortality rates of the general population as the reference, to estimate the relative mortality risk of T1DM. RESULTS: The number of male and female T1DM was 3,471 (48%) and 3,754 (52%), respectively. The annual number of incident T1DM increased from 543 in 1999 to 737 in 2010. The overall bi-annual incidence rate rose from 1999-00 to 2003-04 and mildly declined thereafter rose to 2009-10, with an insignificant trend (P = 0.489) over the study period. Regardless of gender, the higher age-specific incidence rate was noted in the younger groups (<30 years) and highest at <15 years. The incidence rates in younger groups were constantly higher in female population than in male one. The SMR from all causes was significantly increased at 3.00 (95% Confidence Interval (CI) 2.83-3.16) in patients with T1DM. The sex-specific SMR was 2.66 (95% CI 2.46-2.85) and 3.58 (95% CI 3.28-3.87) for male and female patients, respectively. For both sexes, the age-specific SMR peaked at 15-29 years. CONCLUSIONS: Among T1DM patients in Taiwan, there were significant increasing trends in males and female aged <15 years. We also noted a significantly increased overall and sex-specific SMR from all causes in patients with TIDM which suggests a need for improvements in treatment and care of patients with T1DM.

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  • In Taiwan, women with type 1 diabetes mellitus aged ≥60 years were at slightly increased risk of mortality compared with women in the general population (SMR 1.28, 95% CI 1.06-1.50), and no increased risk was observed among men (SMR 0.93, 95% CI 0.77-1.10).

    “In Taiwan, women with T1DM aged ≥60 years were at slightly increased risk of mortality compared with women in the general population of the same age (SMR 1.28, 95% CI 1.06–1.50), and no increased risk was observed among men (SMR 0.93, 95% CI 0.77–1.10)20.”

    From The epidemiology of type 1 diabetes mellitus in older adults (2025) · cites this paper as [20]

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  • In Taiwan, type 1 diabetes mellitus incidence in women aged ≥60 years was 0.67 per 100,000 in 2009-2010, more than double the incidence of 0.29 per 100,000 in men.

    “One, using National Health Insurance data, found that the incidence in women aged ≥60 years was 0.67 per 100,000 individuals in 2009–2010; this was more than double the incidence of 0.29 per 100,000 in men for the same period20.”

    From The epidemiology of type 1 diabetes mellitus in older adults (2025) · cites this paper as [20]

    Table 1 in the Results lists 0.67 per 100,000 for women aged 60 or older in 2009–10, as claimed. It lists 0.39, not 0.29, for men in that age group and period; 0.67 is therefore not more than double the male rate. (LLM, conf=0.94)

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Cited by

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Authors
Lin, W.-H., Wang, M.-C., Wang, W.-M., Yang, D.-C., Lam, C.-F., Roan, J.-N., & Li, C.-Y.
Affiliations
  • National Cheng Kung University Hospital (TW)
  • National Cheng Kung University (TW)
  • China Medical University (TW)
Corresponding author
Li, Chung-Yi
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2014-01-22
Volume
9
Issue
1
Pages
e86172
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0086172
PMC
PMC3899133
OpenAlex
W1999264251
Cited by
67
References
2
Citations by year
2026: 3 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 3 · 2021: 3 · 2020: 6 · 2019: 5 · 2018: 8 · 2017: 4 · 2016: 8 · 2015: 8 · 2014: 5
FWCI
5.47
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Science Council
  • National Health Research Institutes
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
type 1 diabetes, incidence trends, mortality, standardized mortality ratio, sex differences, age-specific incidence, young adults, Taiwan
MeSH terms
Adolescent, Adult, Age Factors, Aged, Child, Diabetes Mellitus, Type 1, Female, Humans, Male, Middle Aged, Mortality, Population Surveillance, Sex Factors, Cohort Studies, Incidence, Age of Onset, Young Adult

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